[Term]
id: PR:000000691
name: cation channel sperm-associated protein 2 isoform 3
def: "A cation channel sperm-associated protein 2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q96P56-3 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]
comment: Category=sequence.
synonym: "CATSPER2/iso:3" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000000670 ! cation channel sperm-associated protein 2

[Term]
id: PR:000000690
name: cation channel sperm-associated protein 2 isoform 2
def: "A cation channel sperm-associated protein 2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q96P56-2 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]
comment: Category=sequence.
synonym: "CATSPER2/iso:2" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000000670 ! cation channel sperm-associated protein 2

[Term]
id: PR:000000692
name: cation channel sperm-associated protein 2 isoform m1
def: "A cation channel sperm-associated protein 2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:A2ARP9-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]
comment: Category=sequence. Note: This isoform has an additional unconventional leucine zipper motif at the C-terminus.
synonym: "CATSPER2/iso:4" RELATED [PRO:DNx]
synonym: "CATSPER2/iso:m1" EXACT PRO-short-label [PRO:DNx]
synonym: "cation channel sperm-associated protein 2 isoform 4" RELATED [PRO:CNA, PRO:DAN]
is_a: PR:000000670 ! cation channel sperm-associated protein 2

[Term]
id: PR:Q96P56-2
name: cation channel sperm-associated protein 2 isoform 2 (human)
def: "A cation channel sperm-associated protein 2 isoform 2 that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "hCATSPER2/iso:2" EXACT PRO-short-label [PRO:DNx]
synonym: "cation channel sperm-associated protein 2 isoform Variant 1 (human)" EXACT [UniProtKB:Q96P56]
xref: UniProtKB:Q96P56-2
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000690 ! cation channel sperm-associated protein 2 isoform 2

[Term]
id: PR:Q96P56
name: cation channel sperm-associated protein 2 (human)
def: "A cation channel sperm-associated protein 2 that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q96P56]
comment: Category=organism-gene.
synonym: "CATSPER2" RELATED Gene-based [UniProtKB:Q96P56]
synonym: "hCATSPER2" EXACT PRO-short-label [PRO:DNx]
synonym: "CatSper2 (human)" EXACT [UniProtKB:Q96P56]
xref: Reactome:R-HSA-2534344 "PR:Q96P56 located_in GO:0005886"
xref: DTO:01100094
xref: UniProtKB:Q96P56
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000670 ! cation channel sperm-associated protein 2
relationship: has_gene_template HGNC:18810 ! CATSPER2 (human)

[Term]
id: PR:000000689
name: cation channel sperm-associated protein 2 isoform 1
def: "A cation channel sperm-associated protein 2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q96P56-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]
comment: Category=sequence.
synonym: "CATSPER2/iso:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000000670 ! cation channel sperm-associated protein 2

[Term]
id: PR:Q96P56-4
name: cation channel sperm-associated protein 2 isoform h4 (human)
def: "A cation channel sperm-associated protein 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q96P56-4." [PRO:DNx, UniProtKB:Q96P56]
comment: Category=organism-sequence.
synonym: "hCATSPER2/iso:h4" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q96P56-4
is_a: PR:Q96P56 ! cation channel sperm-associated protein 2 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:A2ARP9-1
name: cation channel sperm-associated protein 2 isoform m1 (mouse)
def: "A cation channel sperm-associated protein 2 isoform m1 that is encoded in the genome of mouse." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "mCATSPER2/iso:m1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:A2ARP9-1
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000000692 ! cation channel sperm-associated protein 2 isoform m1

[Term]
id: PR:Q6AXP6
name: cation channel sperm-associated protein 2 (rat)
def: "A cation channel sperm-associated protein 2 that is encoded in the genome of rat." [OMA:Q6AXP6, PANTHER:PTHR10037:SF6, PRO:DNx]
comment: Category=organism-gene.
synonym: "Catsper2" RELATED Gene-based [UniProtKB:Q6AXP6]
synonym: "rCATSPER2" EXACT PRO-short-label [PRO:DNx]
synonym: "CatSper2 (rat)" EXACT [UniProtKB:Q6AXP6]
xref: UniProtKB:Q6AXP6
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000000670 ! cation channel sperm-associated protein 2
relationship: has_gene_template RGD:1307620 ! Catsper2 (rat)

[Term]
id: PR:000000670
name: cation channel sperm-associated protein 2
def: "A CatSper channel protein that is a translation product of the human CATSPER2 gene or a 1:1 ortholog thereof. In mammals, four CatSper ion channel subunit genes (CatSpers 1-4) are required for sperm cell hyperactivation and male fertility. The four proteins assemble (presumably as a tetramer) to form a sperm-specific, alkalinization-activated Ca(2+)-selective channel. CatSper channels seem to require auxiliary subunits, such as CatSperB (PR:000000672). In common with other channels, CatSper2 proteins have an architecture consisting of six transmembrane domains (S1-S6), arranged in a voltage sensor (S1-S4) and pore modules (S5-P-S6), and with both N and C termini on the intracellular side of the membrane." [PRO:CNA]
comment: Category=gene.
synonym: "CATSPER2" EXACT PRO-short-label [PRO:DNx]
synonym: "CatSper2" EXACT []
xref: IUPHARobj:389
is_a: PR:000044645 ! CatSper channel protein

[Term]
id: PR:Q96P56-1
name: cation channel sperm-associated protein 2 isoform 1 (human)
def: "A cation channel sperm-associated protein 2 isoform 1 that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "hCATSPER2/iso:1" EXACT PRO-short-label [PRO:DNx]
synonym: "cation channel sperm-associated protein 2 isoform Variant 2 (human)" EXACT [UniProtKB:Q96P56]
xref: UniProtKB:Q96P56-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000689 ! cation channel sperm-associated protein 2 isoform 1

[Term]
id: PR:Q96P56-3
name: cation channel sperm-associated protein 2 isoform 3 (human)
def: "A cation channel sperm-associated protein 2 isoform 3 that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "hCATSPER2/iso:3" EXACT PRO-short-label [PRO:DNx]
synonym: "cation channel sperm-associated protein 2 isoform Variant 3 (human)" EXACT [UniProtKB:Q96P56]
xref: UniProtKB:Q96P56-3
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000691 ! cation channel sperm-associated protein 2 isoform 3

[Term]
id: PR:A2ARP9
name: cation channel sperm-associated protein 2 (mouse)
def: "A cation channel sperm-associated protein 2 that is encoded in the genome of mouse." [OMA:A2ARP9, PRO:DNx]
comment: Category=organism-gene.
synonym: "Catsper2" RELATED Gene-based [UniProtKB:A2ARP9]
synonym: "mCATSPER2" EXACT PRO-short-label [PRO:DNx]
synonym: "CatSper2 (mouse)" EXACT [UniProtKB:A2ARP9]
xref: UniProtKB:A2ARP9
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000000670 ! cation channel sperm-associated protein 2
relationship: has_gene_template MGI:2387404 ! Catsper2 (mouse)