[Term]
id: PR:000000681
name: transient receptor potential cation channel TRPV
def: "A transient receptor potential channel protein that is a member of the subfamily V of the transient receptor potential cation channels (TRPs), with amino- and carboxyl-terminal intracellular domains separated by a domain (common with other ion channels) containing six transmembrane helices (S1-S6) in which the last two helices (S5 and S6) flank a loop, called the pore loop, which determines ion selectivity. The amino-terminal domain contains up to 6 copies of detectable ankyrin repeat (Pfam:PF00023). Most TRPs are relatively non-selective. They may be modulated by voltage changes but channel gating is generally effected by other means." [PMID:16382100, PMID:16460286, PMID:17579562, PRO:WCB]
comment: Category=family.
synonym: "fam:TRPV" EXACT PRO-short-label [PRO:DAN]
xref: PIRSF:PIRSF038527
is_a: PR:000044657 ! transient receptor potential channel protein