[Term]
id: PR:000000710
name: shal-related voltage-gated potassium channel alpha subunit
def: "A voltage-gated potassium channel alpha subunit that is a constituent of the Kv4 channels, responsible for transient, voltage-dependent potassium currents (A currents) in the brain and heart. The unique motif KSCASE is absolutely conserved in all shal-related channel subunits. Mutations in this region drastically affect deactivation and inactivation. This motif is located in the cytoplasmic S4-S5 loop. In common with Kv2 and Kv3 channels, the tetramerization domain at the N terminus contains a zinc binding site. Kv.4 channels are modulated by Kv4 Channel Interacting Proteins (KChIPs1-4), which bind to the cytoplasmic N-terminal domain." [PMID:15555915]
comment: Category=family.
synonym: "Kv4" RELATED []
synonym: "fam:Kchan_shal_sub-a" EXACT PRO-short-label [PRO:DAN]
synonym: "A-type potassium channel" RELATED []
synonym: "pore-forming Kv4 alpha subunits" RELATED []
xref: PIRSF:PIRSF500983
is_a: PR:000000685 ! voltage-gated potassium channel alpha subunit