[Term]
id: PR:000000711
name: shaw-related voltage-gated potassium channel alpha subunit
def: "A voltage-gated potassium channel alpha subunit that is a constituent of Kv3 channels. These proteins are characterized by the high sequence conservation in the S5 segment which seems to determine the gating properties of the Kv3 channels: rightward shifted voltage dependence and fast deactivation rates. They also contain an ATM motif at the lysine-rich C-terminal region that is unique to this group. Kv3 channels are necessary for high-frequency, repetitive firing of action potentials. High activation threshold is a hallmark of Kv3 channels. They regulate rapid spiking, transmitter release and dendritic integration of many central neurons. In common with Kv2 and Kv4 channels, the tetramerization domain at the N terminus contains a zinc-binding site." [PMID:11506885]
comment: Category=family.
synonym: "Kv3 channel" RELATED []
synonym: "fam:Kchan_shaw_sub-a" EXACT PRO-short-label [PRO:DAN]
xref: PIRSF:PIRSF500973
is_a: PR:000000685 ! voltage-gated potassium channel alpha subunit