[Term] id: PR:000000803 name: voltage-gated potassium channel KCNV2 sequence variant G459D (human) def: "A potassium voltage-gated channel subfamily V member 2 (human) that has an Asp residue at the position equivalent to Gly-459 of the amino acid sequence represented by UniProtKB:Q8TDN2. UniProtKB:Q8TDN2, Gly-459, CHEBI:29958." [PMID:16909397, PRO:CNA, PRO:DAN] comment: Category=organism-sequence. Note: This residue is located in the loop connecting segments S5 and S6. synonym: "hKCNV2/var:G459D" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:Q8TDN2, Gly-459, CHEBI:29958" EXACT PRO-proteoform-std [PRO:DAN] synonym: "voltage-gated potassium channel KCNV2 sequence variant 1 (human)" EXACT [PRO:DNx] xref: UniProtKB_VAR:VAR_027637 is_a: PR:Q8TDN2 ! potassium voltage-gated channel subfamily V member 2 (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000000804 name: voltage-gated potassium channel KCNV2 sequence variant A259V (human) def: "A potassium voltage-gated channel subfamily V member 2 (human) that has a Val residue at the position equivalent to Ala-259 of the amino acid sequence represented by UniProtKB:Q8TDN2. UniProtKB:Q8TDN2, Ala-259, CHEBI:30015." [PMID:16909397, PRO:CNA, PRO:DAN] comment: Category=organism-sequence. Note: This residue is located in the loop connecting segments S1 and S2. synonym: "hKCNV2/var:A259V" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:Q8TDN2, Ala-259, CHEBI:30015" EXACT PRO-proteoform-std [PRO:DAN] synonym: "voltage-gated potassium channel KCNV2 sequence variant 2 (human)" EXACT [PRO:DNx] xref: UniProtKB_VAR:VAR_027635 is_a: PR:Q8TDN2 ! potassium voltage-gated channel subfamily V member 2 (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000000805 name: voltage-gated potassium channel KCNV2 sequence variant L126Q (human) def: "A potassium voltage-gated channel subfamily V member 2 (human) that has a Gln residue at the position equivalent to Leu-126 of the amino acid sequence represented by UniProtKB:Q8TDN2. UniProtKB:Q8TDN2, Leu-126, CHEBI:30011." [PMID:16909397, PRO:CNA, PRO:DAN] comment: Category=organism-sequence. Note: This residue is located in the cytoplasmic N terminus. synonym: "hKCNV2/var:L126Q" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:Q8TDN2, Leu-126, CHEBI:30011" EXACT PRO-proteoform-std [PRO:DAN] synonym: "voltage-gated potassium channel KCNV2 sequence variant 3 (human)" EXACT [PRO:DNx] xref: UniProtKB_VAR:VAR_027632 is_a: PR:Q8TDN2 ! potassium voltage-gated channel subfamily V member 2 (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000000806 name: voltage-gated potassium channel KCNV2 sequence variant 4 (human) def: "A potassium voltage-gated channel subfamily V member 2 (human) that has a three-residue deletion at the positions equivalent to 339-341 of the amino acid sequence represented by UniProtKB:Q8TDN2. These residues are part of segment S3. UniProtKB:Q8TDN2, 1-338, 342-545." [PMID:16909397, PRO:CNA, PRO:DAN] comment: Category=organism-sequence. synonym: "hKCNV2/var:4" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:Q8TDN2, 1-338, 342-545" EXACT PRO-proteoform-std [PRO:DAN] xref: UniProtKB_VAR:VAR_027636 is_a: PR:Q8TDN2 ! potassium voltage-gated channel subfamily V member 2 (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000000807 name: voltage-gated potassium channel KCNV2 sequence variant S256W (human) def: "A potassium voltage-gated channel subfamily V member 2 (human) that has a Trp residue at the position equivalent to Ser-256 of the amino acid sequence represented by UniProtKB:Q8TDN2. UniProtKB:Q8TDN2, Ser-256, CHEBI:29954." [PMID:16909397, PRO:CNA, PRO:DAN] comment: Category=organism-sequence. Note: This residue is located in the loop connecting segments S1 and S2. synonym: "hKCNV2/var:S256W" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:Q8TDN2, Ser-256, CHEBI:29954" EXACT PRO-proteoform-std [PRO:DAN] synonym: "voltage-gated potassium channel KCNV2 sequence variant 5 (human)" EXACT [PRO:DNx] xref: UniProtKB_VAR:VAR_027634 is_a: PR:Q8TDN2 ! potassium voltage-gated channel subfamily V member 2 (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000000808 name: voltage-gated potassium channel KCNV2 sequence variant W188C (human) def: "A potassium voltage-gated channel subfamily V member 2 (human) that has a Cys residue at the position equivalent to Trp-188 of the amino acid sequence represented by UniProtKB:Q8TDN2. UniProtKB:Q8TDN2, Trp-188, CHEBI:29950." [PMID:16909397, PRO:CNA, PRO:DAN] comment: Category=organism-sequence. Note: This residue is located in the loop connecting segments S1 and S2. synonym: "hKCNV2/var:W188C" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:Q8TDN2, Trp-188, CHEBI:29950" EXACT PRO-proteoform-std [PRO:DAN] synonym: "voltage-gated potassium channel KCNV2 sequence variant 6 (human)" EXACT [PRO:DNx] xref: UniProtKB_VAR:VAR_027633 is_a: PR:Q8TDN2 ! potassium voltage-gated channel subfamily V member 2 (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000000726 name: voltage-gated potassium channel KCNV2 def: "A voltage-gated potassium channel alpha subunit that is a translation product of the human KCNV2 gene or a 1:1 ortholog thereof. Similarly to KCNF1, KCNV1 and KCNS, KCNV2 subunits are not able to form functional channels on their own. Also in common with these modulatory subunits, it lacks the conserved PxP motif located in the distal part of S6. In this class the motif is PIS. The alteration of the PxP motif seems to be an important determinant of the regulatory function of modulatory subunits." [PRO:CNA] comment: Category=gene. synonym: "KCNV2" EXACT PRO-short-label [PRO:DNx] synonym: "voltage-gated potassium channel subunit Kv8.2" EXACT [] xref: IUPHARobj:566 is_a: PR:000000685 ! voltage-gated potassium channel alpha subunit [Term] id: PR:Q8TDN2-1 name: potassium voltage-gated channel subfamily V member 2 isoform 1 (human) def: "A voltage-gated potassium channel KCNV2 isoform 1 that is encoded in the genome of human." [PRO:CNA] comment: Category=organism-sequence. synonym: "hKCNV2/iso:1" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q8TDN2-1 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000000802 ! voltage-gated potassium channel KCNV2 isoform 1 [Term] id: PR:Q8TDN2 name: potassium voltage-gated channel subfamily V member 2 (human) def: "A voltage-gated potassium channel KCNV2 that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q8TDN2] comment: Category=organism-gene. synonym: "KCNV2" RELATED Gene-based [UniProtKB:Q8TDN2] synonym: "hKCNV2" EXACT PRO-short-label [PRO:DNx] synonym: "voltage-gated potassium channel subunit Kv8.2 (human)" EXACT [UniProtKB:Q8TDN2] xref: Reactome:R-HSA-977505 "PR:Q8TDN2 located_in GO:0005886" xref: DTO:01100244 xref: UniProtKB:Q8TDN2 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000000726 ! voltage-gated potassium channel KCNV2 relationship: has_gene_template HGNC:19698 ! KCNV2 (human)