[Term]
id: PR:000000812
name: voltage-gated potassium channel subunit KCNA5
def: "A shaker-related voltage-gated potassium channel alpha subunit that is a translation product of the human KCNA5 gene or a 1:1 ortholog thereof. The voltage-gated potassium channel Kv1.5 mediates the ultrarapid-activating potassium current (IKur) in heart, and also plays a critical role in the regulation of arterial tone." [PMID:10575199, PMID:16772329, PMID:18344374]
comment: Category=gene.
synonym: "HPCN1" EXACT []
synonym: "KCNA5" EXACT PRO-short-label [PRO:DNx]
synonym: "KV1-5" EXACT []
synonym: "voltage-gated potassium channel HK2" EXACT []
synonym: "voltage-gated potassium channel subunit Kv1.5" EXACT []
xref: IUPHARobj:542
is_a: PR:000000709 ! shaker-related voltage-gated potassium channel alpha subunit

[Term]
id: PR:P22460-2
name: potassium voltage-gated channel subfamily A member 5 isoform h2 (human)
def: "A potassium voltage-gated channel subfamily A member 5 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P22460-2." [PRO:DNx, UniProtKB:P22460]
comment: Category=organism-sequence.
synonym: "hKCNA5/iso:h2" EXACT PRO-short-label [PRO:DNx]
synonym: "potassium voltage-gated channel subfamily A member 5 isoform Short (human)" EXACT [UniProtKB:P22460]
xref: UniProtKB:P22460-2
is_a: PR:P22460 ! potassium voltage-gated channel subfamily A member 5 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q61762
name: potassium voltage-gated channel subfamily A member 5 (mouse)
def: "A voltage-gated potassium channel subunit KCNA5 that is encoded in the genome of mouse." [OMA:Q61762, PRO:DNx]
comment: Category=organism-gene.
synonym: "Kcna5" RELATED Gene-based [UniProtKB:Q61762]
synonym: "mKCNA5" EXACT PRO-short-label [PRO:DNx]
synonym: "KV1-5 (mouse)" EXACT [UniProtKB:Q61762]
synonym: "voltage-gated potassium channel subunit Kv1.5 (mouse)" EXACT [UniProtKB:Q61762]
xref: UniProtKB:Q61762
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000000812 ! voltage-gated potassium channel subunit KCNA5
relationship: has_gene_template MGI:96662 ! Kcna5 (mouse)

[Term]
id: PR:P22460-1
name: potassium voltage-gated channel subfamily A member 5 isoform 1 (human)
def: "A voltage-gated potassium channel subunit KCNA5 isoform 1 that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "hKCNA5/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P22460-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000974 ! voltage-gated potassium channel subunit KCNA5 isoform 1

[Term]
id: PR:000000974
name: voltage-gated potassium channel subunit KCNA5 isoform 1
def: "A voltage-gated potassium channel subunit KCNA5 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P22460-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]
comment: Category=sequence.
synonym: "KCNA5/iso:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000000812 ! voltage-gated potassium channel subunit KCNA5

[Term]
id: PR:000000975
name: voltage-gated potassium channel subunit KCNA5 isoform 2
def: "A voltage-gated potassium channel subunit KCNA5 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q61762-2 or a 1:1 ortholog thereof." [PMID:11524461, PMID:8226976, PRO:CNA, PRO:DAN]
comment: Category=sequence. Note: This isoform lacks the N terminus tetramerization domain.
synonym: "KCNA5/iso:2" EXACT PRO-short-label [PRO:DNx]
synonym: "Kv1-5delta5'" RELATED []
synonym: "voltage-gated potassium channel subfamily A member 5 isoform 2" RELATED []
is_a: PR:000000812 ! voltage-gated potassium channel subunit KCNA5

[Term]
id: PR:000000976
name: voltage-gated potassium channel subunit KCNA5 isoform 3
def: "A voltage-gated potassium channel subunit KCNA5 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q61762-3 or a 1:1 ortholog thereof." [PMID:8226976, PRO:CNA, PRO:DAN]
comment: Category=sequence.
synonym: "KCNA5/iso:3" EXACT PRO-short-label [PRO:DNx]
synonym: "Kv1-5delta3'" RELATED []
synonym: "voltage-gated potassium channel subfamily A member 5 isoform 3" RELATED []
is_a: PR:000000812 ! voltage-gated potassium channel subunit KCNA5

[Term]
id: PR:000002684
name: voltage-gated potassium channel subunit KCNA5 isoform 2 unmodified form
def: "A voltage-gated potassium channel subunit KCNA5 isoform 2 that has not been subjected to any co- or post-translational residue modification or peptide bond cleavage." [PRO:DNx]
comment: Category=modification.
synonym: "KCNA5/iso:2/UnMod" EXACT PRO-short-label [PRO:DNx]
intersection_of: PR:000000975 ! voltage-gated potassium channel subunit KCNA5 isoform 2
intersection_of: has_part PR:000021935 ! immature protein part
intersection_of: lacks_part PR:000025513 ! modified amino-acid residue
disjoint_from: PR:000018264 ! proteolytic cleavage product

[Term]
id: PR:P22460
name: potassium voltage-gated channel subfamily A member 5 (human)
def: "A voltage-gated potassium channel subunit KCNA5 that is encoded in the genome of human." []
comment: Category=organism-gene.
synonym: "KCNA5" RELATED Gene-based [UniProtKB:P22460]
synonym: "hKCNA5" EXACT PRO-short-label [PRO:DNx]
synonym: "HPCN1 (human)" EXACT [UniProtKB:P22460]
synonym: "voltage-gated potassium channel HK2 (human)" EXACT [UniProtKB:P22460]
synonym: "voltage-gated potassium channel subunit Kv1.5 (human)" EXACT [UniProtKB:P22460]
xref: Reactome:R-HSA-977472 "PR:P22460 located_in GO:0005886"
xref: DTO:01100184
xref: UniProtKB:P22460
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000812 ! voltage-gated potassium channel subunit KCNA5
relationship: has_gene_template HGNC:6224 ! KCNA5 (human)

[Term]
id: PR:000036568
name: potassium voltage-gated channel subfamily A member 5 isoform 1 sequence variant E375* (human)
def: "A potassium voltage-gated channel subfamily A member 5 isoform 1 (human) that has a C-terminal truncation and thus lacks the S4-S6 voltage sensor, pore region and C terminus, but preserves the N terminus and S1-S3 transmembrane domains that secure tetrameric subunit assembly. UniProtKB:P22460-1, 1-374." [PMID:16772329, PRO:CNA]
comment: Category=organism-sequence.
synonym: "hKCNA5/iso:1/var:E375*" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P22460-1, 1-374" EXACT PRO-proteoform-std [PRO:DAN]
is_a: PR:P22460-1 ! potassium voltage-gated channel subfamily A member 5 isoform 1 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P19024
name: potassium voltage-gated channel subfamily A member 5 (rat)
def: "A voltage-gated potassium channel subunit KCNA5 that is encoded in the genome of rat." [OMA:P19024, PANTHER:PTHR11537:SF25, PRO:DNx]
comment: Category=organism-gene.
synonym: "Kcna5" RELATED Gene-based [UniProtKB:P19024]
synonym: "rKCNA5" EXACT PRO-short-label [PRO:DNx]
synonym: "RK4 (rat)" EXACT [UniProtKB:P19024]
synonym: "RCK7 (rat)" EXACT [UniProtKB:P19024]
synonym: "voltage-gated potassium channel subunit Kv1.5 (rat)" EXACT [UniProtKB:P19024]
xref: UniProtKB:P19024
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000000812 ! voltage-gated potassium channel subunit KCNA5
relationship: has_gene_template RGD:2953 ! Kcna5 (rat)

[Term]
id: PR:Q61762-1
name: potassium voltage-gated channel subfamily A member 5 isoform 1 (mouse)
def: "A voltage-gated potassium channel subunit KCNA5 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "mKCNA5/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q61762-1
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000000974 ! voltage-gated potassium channel subunit KCNA5 isoform 1

[Term]
id: PR:Q61762-3
name: potassium voltage-gated channel subfamily A member 5 isoform 3 (mouse)
def: "A voltage-gated potassium channel subunit KCNA5 isoform 3 that is encoded in the genome of mouse." [PRO:DNx, UniProtKB:Q61762]
comment: Category=organism-sequence.
synonym: "mKCNA5/iso:3" EXACT PRO-short-label [PRO:DNx]
synonym: "potassium voltage-gated channel subfamily A member 5 isoform 3' (mouse)" EXACT [UniProtKB:Q61762]
xref: UniProtKB:Q61762-3
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000000976 ! voltage-gated potassium channel subunit KCNA5 isoform 3

[Term]
id: PR:Q61762-2
name: potassium voltage-gated channel subfamily A member 5 isoform 2 (mouse)
def: "A voltage-gated potassium channel subunit KCNA5 isoform 2 that is encoded in the genome of mouse." [PRO:DNx, UniProtKB:Q61762]
comment: Category=organism-sequence.
synonym: "mKCNA5/iso:2" EXACT PRO-short-label [PRO:DNx]
synonym: "potassium voltage-gated channel subfamily A member 5 isoform 5' (mouse)" EXACT [UniProtKB:Q61762]
xref: UniProtKB:Q61762-2
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000000975 ! voltage-gated potassium channel subunit KCNA5 isoform 2