[Term]
id: PR:P15391
name: B-lymphocyte antigen CD19 (human)
def: "A CD19 molecule that is encoded in the genome of human." []
comment: Category=organism-gene.
synonym: "CD19" RELATED Gene-based [UniProtKB:P15391]
synonym: "hCD19" EXACT PRO-short-label [PRO:DNx]
synonym: "differentiation antigen CD19 (human)" EXACT [UniProtKB:P15391]
synonym: "T-cell surface antigen Leu-12 (human)" EXACT [UniProtKB:P15391]
synonym: "B-lymphocyte surface antigen B4 (human)" EXACT [UniProtKB:P15391]
xref: UniProtKB:P15391
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000001002 ! CD19 molecule
relationship: has_gene_template HGNC:1633 ! CD19 (human)

[Term]
id: PR:000001002
name: CD19 molecule
def: "A protein that is a translation product of the human CD19 gene or a 1:1 ortholog thereof. It is composed of an N-terminal extracellular domain containing two Ig-like C2-type (immunoglobulin-like) domains, followed by a single-pass transmembrane segment and a cytoplasmic C-terminal tail. CD19 expression is restricted to members of the B cell lineage. It functions as a co-receptor for B-cell antigen receptor (BCR), regulating signal transduction." [PMID:15778510]
comment: Category=gene. Requested by=CL.
synonym: "CD19" EXACT PRO-short-label [PRO:DNx]
synonym: "differentiation antigen CD19" EXACT []
synonym: "T-cell surface antigen Leu-12" EXACT []
synonym: "B-lymphocyte surface antigen B4" EXACT []
xref: IUPHARobj:2764
xref: PIRSF:PIRSF016630
is_a: PR:000000001 ! protein

[Term]
id: PR:P15391-2
name: B-lymphocyte antigen CD19 isoform h2 (human)
def: "A B-lymphocyte antigen CD19 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P15391-2." [PRO:DNx, UniProtKB:P15391]
comment: Category=organism-sequence.
synonym: "hCD19/iso:h2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P15391-2
is_a: PR:P15391 ! B-lymphocyte antigen CD19 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P15391-1
name: B-lymphocyte antigen CD19 isoform h1 (human)
def: "A B-lymphocyte antigen CD19 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P15391-1." [PRO:DNx, UniProtKB:P15391]
comment: Category=organism-sequence.
synonym: "hCD19/iso:h1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P15391-1
is_a: PR:P15391 ! B-lymphocyte antigen CD19 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000046613
name: B-lymphocyte antigen CD19, signal peptide removed phosphorylated 1 (human)
def: "A B-lymphocyte antigen CD19 (human) that has had the signal peptide removed and has been post-translationally modified to include phosphotyrosine at positions 348, 378, 409, 439, 500 and 531 of the amino acid sequence represented by UniProtKB:P15391. UniProtKB:P15391, 20-556, Tyr-348/Tyr-378/Tyr-409/Tyr-439/Tyr-500/Tyr-531, MOD:00048." [PRO:DNx, Reactome:R-HSA-2076270]
comment: Category=organism-modification.
synonym: "hCD19/SigPep-/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000014648, Tyr-348/Tyr-378/Tyr-409/Tyr-439/Tyr-500/Tyr-531, MOD:00048" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P15391, 20-556, Tyr-348/Tyr-378/Tyr-409/Tyr-439/Tyr-500/Tyr-531, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-2076270 "PR:000046613 located_in GO:0005886"
is_a: PR:P15391 ! B-lymphocyte antigen CD19 (human)
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part SO:0000418 ! signal_peptide

[Term]
id: PR:000046612
name: B-lymphocyte antigen CD19, signal peptide removed form (human)
def: "A B-lymphocyte antigen CD19 (human) that has had the signal peptide removed. UniProtKB:P15391, 20-556." [PRO:DNx, Reactome:R-HSA-197740]
comment: Category=organism-modification.
synonym: "hCD19/SigPep-" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000014648" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P15391, 20-556" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-197740 "PR:000046612 located_in GO:0005886"
intersection_of: PR:P15391 ! B-lymphocyte antigen CD19 (human)
intersection_of: lacks_part SO:0000418 ! signal_peptide
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens