[Term]
id: PR:000001003
name: CD34 molecule
def: "A protein that is a translation product of the human CD34 gene or a 1:1 ortholog thereof. It is a leukocyte membrane protein expressed specifically by lymphohematopoietic progenitor cells. It contains a single-pass transmembrane domain and that show distinct expression on early hematopoietic precursors and vascular-associated tissue. Acts as a scaffold that presents selectin carbohydrate ligands in a clustered, tissue specific manner to allow for higher avidity interactions between leukocytes and endothelial cells during the inflammatory process. In common with related sialomucins (endoglycan and podocalyxin), the extracellular region is dominated by an N-terminal mucin-like domain, which is densely substituted with sialylated O-linked carbohydrates. The mucin-like region is followed by a cysteine-containing and presumably globular domain. This domain may fold into an immunoglobulin-like structure as the positions of 2 of the cysteines are conserved in the C2 set of the immunoglobulin superfamily. The cytoplasmic domain is around 73-76 residues long and highly conserved." [PMID:16720896, PMID:8983065]
comment: Category=gene. Requested by=CL.
synonym: "CD34" EXACT PRO-short-label [PRO:DNx]
synonym: "hematopoietic progenitor cell antigen CD34" EXACT []
xref: PIRSF:PIRSF028749
is_a: PR:000000001 ! protein

[Term]
id: PR:Q64314-1
name: hematopoietic progenitor cell antigen CD34 isoform Long (mouse)
def: "A hematopoietic progenitor cell antigen CD34 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q64314-1." [PRO:DNx, UniProtKB:Q64314]
comment: Category=organism-sequence.
synonym: "mCD34/iso:Long" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q64314-1
is_a: PR:Q64314 ! hematopoietic progenitor cell antigen CD34 (mouse)
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:Q64314
name: hematopoietic progenitor cell antigen CD34 (mouse)
def: "A CD34 molecule that is encoded in the genome of mouse." [OMA:Q64314, PRO:DNx]
comment: Category=organism-gene.
synonym: "Cd34" RELATED Gene-based [UniProtKB:Q64314]
synonym: "mCD34" EXACT PRO-short-label [PRO:DNx]
synonym: "CD34 (mouse)" EXACT [UniProtKB:Q64314]
xref: UniProtKB:Q64314
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000001003 ! CD34 molecule
relationship: has_gene_template MGI:88329 ! Cd34 (mouse)

[Term]
id: PR:Q64314-2
name: hematopoietic progenitor cell antigen CD34 isoform Short (mouse)
def: "A hematopoietic progenitor cell antigen CD34 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q64314-2." [PRO:DNx, UniProtKB:Q64314]
comment: Category=organism-sequence.
synonym: "mCD34/iso:Short" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q64314-2
is_a: PR:Q64314 ! hematopoietic progenitor cell antigen CD34 (mouse)
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus