[Term]
id: PR:000018315
name: integrin alpha-M, signal peptide removed form
def: "An integrin alpha-M that has had the signal peptide removed." [PRO:DNx]
comment: Category=modification.
synonym: "ITGAM/SigPep-" EXACT PRO-short-label [PRO:DNx]
intersection_of: PR:000001012 ! integrin alpha-M
intersection_of: lacks_part SO:0000418 ! signal_peptide

[Term]
id: PR:P11215-2
name: integrin alpha-M isoform h2 (human)
def: "An integrin alpha-M (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P11215-2." [PRO:DNx, UniProtKB:P11215]
comment: Category=organism-sequence.
synonym: "hITGAM/iso:h2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P11215-2
is_a: PR:P11215 ! integrin alpha-M (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P11215-1
name: integrin alpha-M isoform h1 (human)
def: "An integrin alpha-M (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P11215-1." [PRO:DNx, UniProtKB:P11215]
comment: Category=organism-sequence.
synonym: "hITGAM/iso:h1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P11215-1
is_a: PR:P11215 ! integrin alpha-M (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P05555-1
name: integrin alpha-M isoform m1 (mouse)
def: "An integrin alpha-M (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P05555-1." [PRO:DNx, UniProtKB:P05555]
comment: Category=organism-sequence.
synonym: "mITGAM/iso:m1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P05555-1
is_a: PR:P05555 ! integrin alpha-M (mouse)
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:P05555-2
name: integrin alpha-M isoform m2 (mouse)
def: "An integrin alpha-M (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P05555-2." [PRO:DNx, UniProtKB:P05555]
comment: Category=organism-sequence.
synonym: "mITGAM/iso:m2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P05555-2
is_a: PR:P05555 ! integrin alpha-M (mouse)
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:P11215
name: integrin alpha-M (human)
def: "An integrin alpha-M that is encoded in the genome of human." [PRO:DNx, UniProtKB:P11215]
comment: Category=organism-gene.
synonym: "CR3A" RELATED Gene-based [UniProtKB:P11215]
synonym: "CD11B" RELATED Gene-based [UniProtKB:P11215]
synonym: "ITGAM" RELATED Gene-based [UniProtKB:P11215]
synonym: "hITGAM" EXACT PRO-short-label [PRO:DNx]
synonym: "CR-3 alpha chain (human)" EXACT [UniProtKB:P11215]
synonym: "neutrophil adherence receptor (human)" EXACT [UniProtKB:P11215]
synonym: "leukocyte adhesion receptor MO1 (human)" EXACT [UniProtKB:P11215]
synonym: "CD11 antigen-like family member B (human)" EXACT [UniProtKB:P11215]
synonym: "cell surface glycoprotein MAC-1 subunit alpha (human)" EXACT [UniProtKB:P11215]
xref: UniProtKB:P11215
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000001012 ! integrin alpha-M
relationship: has_gene_template HGNC:6149 ! ITGAM (human)

[Term]
id: PR:000001012
name: integrin alpha-M
def: "An integrin alpha with A domain that is a translation product of the human ITGAM gene or a 1:1 ortholog thereof. They constitute subunits of the integrin alpha-M/beta-2 receptor. This receptor is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is also a receptor for fibrinogen, factor X and ICAM1." [UniProtKB:P11215]
comment: Category=gene. Requested by=CL.
synonym: "CR3A" RELATED Gene-based []
synonym: "CD11B" RELATED Gene-based []
synonym: "CD11b" EXACT []
synonym: "ITGAM" EXACT PRO-short-label [PRO:DNx]
synonym: "CR-3 alpha chain" EXACT []
synonym: "neutrophil adherence receptor" EXACT []
synonym: "leukocyte adhesion receptor MO1" EXACT []
synonym: "CD11 antigen-like family member B" EXACT []
synonym: "cell surface glycoprotein MAC-1 subunit alpha" EXACT []
xref: IUPHARobj:2452
is_a: PR:000001005 ! integrin alpha with A domain

[Term]
id: PR:000027393
name: integrin alpha-M, signal peptide removed form (human)
def: "An integrin alpha-M, signal peptide removed form in human. Example: UniProtKB:P11215-1, 17-1152." [PRO:DNx]
comment: Category=organism-modification.
synonym: "PRO_0000016289" NARROW PRO-proteoform-ftid [PRO:DNx]
synonym: "hITGAM/SigPep-" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P11215-1, 17-1152" NARROW PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-202757 "PR:000027393 located_in GO:0005886"
xref: Reactome:R-HSA-6799647 "PR:000027393 located_in GO:0035579"
xref: Reactome:R-HSA-6800979 "PR:000027393 located_in GO:0070821"
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000018315 ! integrin alpha-M, signal peptide removed form

[Term]
id: PR:P05555
name: integrin alpha-M (mouse)
def: "An integrin alpha-M that is encoded in the genome of mouse." [PRO:DNx, UniProtKB:P05555]
comment: Category=organism-gene.
synonym: "Itgam" RELATED Gene-based [UniProtKB:P05555]
synonym: "mITGAM" EXACT PRO-short-label [PRO:DNx]
synonym: "CD11b (mouse)" EXACT [UniProtKB:P05555]
synonym: "CR-3 alpha chain (mouse)" EXACT [UniProtKB:P05555]
synonym: "leukocyte adhesion receptor MO1 (mouse)" EXACT [UniProtKB:P05555]
synonym: "CD11 antigen-like family member B (mouse)" EXACT [UniProtKB:P05555]
synonym: "cell surface glycoprotein MAC-1 subunit alpha (mouse)" EXACT [UniProtKB:P05555]
xref: UniProtKB:P05555
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000001012 ! integrin alpha-M
relationship: has_gene_template MGI:96607 ! Itgam (mouse)