[Term]
id: PR:Q9HBA0
name: transient receptor potential cation channel subfamily V member 4 (human)
def: "A transient receptor potential cation channel TRPV4 that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q9HBA0]
comment: Category=organism-gene.
synonym: "VRL2" RELATED Gene-based [UniProtKB:Q9HBA0]
synonym: "TRPV4" RELATED Gene-based [UniProtKB:Q9HBA0]
synonym: "VROAC" RELATED Gene-based [UniProtKB:Q9HBA0]
synonym: "hTRPV4" EXACT PRO-short-label [PRO:DNx]
synonym: "TRP12 (human)" EXACT [UniProtKB:Q9HBA0]
synonym: "TrpV4 (human)" EXACT [UniProtKB:Q9HBA0]
synonym: "VRL-2 (human)" EXACT [UniProtKB:Q9HBA0]
synonym: "OTRPC4 (human)" EXACT [UniProtKB:Q9HBA0]
synonym: "VR-OAC (human)" EXACT [UniProtKB:Q9HBA0]
synonym: "Osm-9-like TRP channel 4 (human)" EXACT [UniProtKB:Q9HBA0]
synonym: "vanilloid receptor-like channel 2 (human)" EXACT [UniProtKB:Q9HBA0]
synonym: "vanilloid receptor-like protein 2 (human)" EXACT [UniProtKB:Q9HBA0]
synonym: "transient receptor potential protein 12 (human)" EXACT [UniProtKB:Q9HBA0]
synonym: "vanilloid receptor-related osmotically-activated channel (human)" EXACT [UniProtKB:Q9HBA0]
xref: Reactome:R-HSA-1297261 "PR:Q9HBA0 located_in GO:0005886"
xref: DTO:01100336
xref: UniProtKB:Q9HBA0
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000001068 ! transient receptor potential cation channel TRPV4
relationship: has_gene_template HGNC:18083 ! TRPV4 (human)

[Term]
id: PR:Q9EPK8-1
name: transient receptor potential cation channel subfamily V member 4 isoform A (mouse)
def: "A transient receptor potential cation channel TRPV4 isoform A that is encoded in the genome of mouse." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "mTRPV4/iso:A" EXACT PRO-short-label [PRO:DNx]
synonym: "Trpv4 isoform 1 (mouse)" EXACT [PRO:DNx]
synonym: "transient receptor potential cation channel subfamily V member 4 isoform 1 (mouse)" EXACT [PRO:DNx]
xref: UniProtKB:Q9EPK8-1
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000001069 ! transient receptor potential cation channel TRPV4 isoform A

[Term]
id: PR:Q9ERZ8
name: transient receptor potential cation channel subfamily V member 4 (rat)
def: "A transient receptor potential cation channel TRPV4 that is encoded in the genome of rat." [OMA:Q9ERZ8, PANTHER:PTHR10582:SF4, PRO:DNx]
comment: Category=organism-gene.
synonym: "Trpv4" RELATED Gene-based [UniProtKB:Q9ERZ8]
synonym: "Vroac" RELATED Gene-based [UniProtKB:Q9ERZ8]
synonym: "rTRPV4" EXACT PRO-short-label [PRO:DNx]
synonym: "TrpV4 (rat)" EXACT [UniProtKB:Q9ERZ8]
synonym: "OTRPC4 (rat)" EXACT [UniProtKB:Q9ERZ8]
synonym: "VR-OAC (rat)" EXACT [UniProtKB:Q9ERZ8]
synonym: "Osm-9-like TRP channel 4 (rat)" EXACT [UniProtKB:Q9ERZ8]
synonym: "vanilloid receptor-related osmotically-activated channel (rat)" EXACT [UniProtKB:Q9ERZ8]
xref: UniProtKB:Q9ERZ8
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000001068 ! transient receptor potential cation channel TRPV4
relationship: has_gene_template RGD:69337 ! Trpv4 (rat)

[Term]
id: PR:Q9HBA0-2
name: transient receptor potential cation channel subfamily V member 4 isoform B (human)
def: "A transient receptor potential cation channel TRPV4 isoform B that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q9HBA0]
comment: Category=organism-sequence.
synonym: "hTRPV4/iso:2" RELATED [PRO:DNx]
synonym: "hTRPV4/iso:B" EXACT PRO-short-label [PRO:DNx]
synonym: "transient receptor potential cation channel subfamily V member 4 isoform 2 (human)" EXACT [UniProtKB:Q9HBA0]
synonym: "transient receptor potential cation channel subfamily V member 4 isoform OTRPC4beta (human)" EXACT [UniProtKB:Q9HBA0]
xref: UniProtKB:Q9HBA0-2
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000001070 ! transient receptor potential cation channel TRPV4 isoform B

[Term]
id: PR:Q9HBA0-6
name: transient receptor potential cation channel subfamily V member 4 isoform E (human)
def: "A transient receptor potential cation channel TRPV4 isoform E that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q9HBA0]
comment: Category=organism-sequence.
synonym: "hTRPV4/iso:6" RELATED [PRO:DNx]
synonym: "hTRPV4/iso:E" EXACT PRO-short-label [PRO:DNx]
synonym: "transient receptor potential cation channel subfamily V member 4 isoform 6 (human)" EXACT [UniProtKB:Q9HBA0]
xref: UniProtKB:Q9HBA0-6
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000001073 ! transient receptor potential cation channel TRPV4 isoform E

[Term]
id: PR:Q9EPK8
name: transient receptor potential cation channel subfamily V member 4 (mouse)
def: "A transient receptor potential cation channel TRPV4 that is encoded in the genome of mouse." [OMA:Q9EPK8, PRO:DNx]
comment: Category=organism-gene.
synonym: "Vrl2" RELATED Gene-based [UniProtKB:Q9EPK8]
synonym: "Trp12" RELATED Gene-based [UniProtKB:Q9EPK8]
synonym: "Trpv4" RELATED Gene-based [UniProtKB:Q9EPK8]
synonym: "Vroac" RELATED Gene-based [UniProtKB:Q9EPK8]
synonym: "mTRPV4" EXACT PRO-short-label [PRO:DNx]
synonym: "TRP12 (mouse)" EXACT [UniProtKB:Q9EPK8]
synonym: "TrpV4 (mouse)" EXACT [UniProtKB:Q9EPK8]
synonym: "OTRPC4 (mouse)" EXACT [UniProtKB:Q9EPK8]
synonym: "VR-OAC (mouse)" EXACT [UniProtKB:Q9EPK8]
synonym: "Osm-9-like TRP channel 4 (mouse)" EXACT [UniProtKB:Q9EPK8]
synonym: "vanilloid receptor-like channel 2 (mouse)" EXACT [UniProtKB:Q9EPK8]
synonym: "vanilloid receptor-like protein 2 (mouse)" EXACT [UniProtKB:Q9EPK8]
synonym: "transient receptor potential protein 12 (mouse)" EXACT [UniProtKB:Q9EPK8]
synonym: "vanilloid receptor-related osmotically-activated channel (mouse)" EXACT [UniProtKB:Q9EPK8]
xref: UniProtKB:Q9EPK8
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000001068 ! transient receptor potential cation channel TRPV4
relationship: has_gene_template MGI:1926945 ! Trpv4 (mouse)

[Term]
id: PR:Q9HBA0-3
name: transient receptor potential cation channel subfamily V member 4 isoform h3 (human)
def: "A transient receptor potential cation channel subfamily V member 4 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9HBA0-3." [PRO:DNx, UniProtKB:Q9HBA0]
comment: Category=organism-sequence.
synonym: "hTRPV4/iso:h3" EXACT PRO-short-label [PRO:DNx]
synonym: "transient receptor potential cation channel subfamily V member 4 isoform TRPV-SV (human)" EXACT [UniProtKB:Q9HBA0]
xref: UniProtKB:Q9HBA0-3
is_a: PR:Q9HBA0 ! transient receptor potential cation channel subfamily V member 4 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q9HBA0-1
name: transient receptor potential cation channel subfamily V member 4 isoform A (human)
def: "A transient receptor potential cation channel TRPV4 isoform A that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "hTRPV4/iso:A" EXACT PRO-short-label [PRO:DNx]
synonym: "TRPV4 isoform 1 (human)" EXACT [PRO:DNx]
synonym: "transient receptor potential cation channel subfamily V member 4 isoform 1 (human)" EXACT [UniProtKB:Q9HBA0]
xref: UniProtKB:Q9HBA0-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000001069 ! transient receptor potential cation channel TRPV4 isoform A

[Term]
id: PR:000046053
name: transient receptor potential cation channel subfamily V member 4 phosphorylated 1 (mouse)
def: "A transient receptor potential cation channel subfamily V member 4 (mouse) that has been phosphorylated at Tyr-253. UniProtKB:Q9EPK8, Tyr-253, MOD:00048." [PMID:12538589, iPTMnet:Q9EPK8]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:12538589). Status=unreviewed.
synonym: "mTRPV4/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q9EPK8, Tyr-253, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:Q9EPK8 ! transient receptor potential cation channel subfamily V member 4 (mouse)
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:A0A1D5PXA5
name: transient receptor potential cation channel subfamily V member 4 (chicken)
def: "A transient receptor potential cation channel TRPV4 that is encoded in the genome of chicken." [PRO:CNA]
comment: Category=organism-gene.
synonym: "TRPV4" RELATED Gene-based [UniProtKB:A0A1D5PXA5]
synonym: "chick-TRPV4" EXACT PRO-short-label [PRO:DNx]
synonym: "TrpV4 (chicken)" EXACT [UniProtKB:A0A1D5PXA5]
synonym: "VR-OAC (chicken)" EXACT [UniProtKB:A0A1D5PXA5]
synonym: "vanilloid receptor-related osmotically activated channel (chicken)" EXACT [UniProtKB:A0A1D5PXA5]
xref: UniProtKB:A0A1D5PXA5
intersection_of: only_in_taxon NCBITaxon:9031 ! Gallus gallus
intersection_of: PR:000001068 ! transient receptor potential cation channel TRPV4
relationship: has_gene_template CGNC:3836 ! TRPV4 (chicken)

[Term]
id: PR:000001072
name: transient receptor potential cation channel TRPV4 isoform D
def: "A transient receptor potential cation channel TRPV4 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9HBA0-5 or a 1:1 ortholog thereof." [PMID:16293632, PRO:CNA, PRO:DAN]
comment: Category=sequence.
synonym: "D" RELATED []
synonym: "TRPV4-D" EXACT []
synonym: "TRPV4/iso:D" EXACT PRO-short-label [PRO:DNx]
synonym: "TRPV4 isoform 4" EXACT [PRO:DNx]
synonym: "transient receptor potential cation channel TRPV4 isoform 4" RELATED []
is_a: PR:000001068 ! transient receptor potential cation channel TRPV4

[Term]
id: PR:000001073
name: transient receptor potential cation channel TRPV4 isoform E
def: "A transient receptor potential cation channel TRPV4 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9HBA0-6 or a 1:1 ortholog thereof." [PMID:16293632, PRO:CNA, PRO:DAN]
comment: Category=sequence.
synonym: "E" RELATED []
synonym: "TRPV-E" EXACT []
synonym: "TRPV4/iso:5" RELATED []
synonym: "TRPV4/iso:E" EXACT PRO-short-label [PRO:DNx]
synonym: "transient receptor potential cation channel TRPV4 isoform 5" RELATED []
is_a: PR:000001068 ! transient receptor potential cation channel TRPV4

[Term]
id: PR:000001070
name: transient receptor potential cation channel TRPV4 isoform B
def: "A transient receptor potential cation channel TRPV4 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9HBA0-2 or a 1:1 ortholog thereof." [PMID:16293632, PRO:CNA, PRO:DAN]
comment: Category=sequence.
synonym: "B" RELATED []
synonym: "TRPV4-B" EXACT []
synonym: "OTRPC4beta" EXACT []
synonym: "TRPV4/iso:2" RELATED []
synonym: "TRPV4/iso:B" EXACT PRO-short-label [PRO:DNx]
synonym: "transient receptor potential cation channel TRPV4 isoform 2" RELATED []
is_a: PR:000001068 ! transient receptor potential cation channel TRPV4

[Term]
id: PR:000001071
name: transient receptor potential cation channel TRPV4 isoform C
def: "A transient receptor potential cation channel TRPV4 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9HBA0-4 or a 1:1 ortholog thereof." [PMID:16293632, PRO:CNA, PRO:DAN]
comment: Category=sequence.
synonym: "C" RELATED []
synonym: "TRPV4-C" EXACT []
synonym: "TRPV4/iso:3" RELATED [PRO:DNx]
synonym: "TRPV4/iso:C" EXACT PRO-short-label [PRO:DNx]
synonym: "transient receptor potential cation channel TRPV4 isoform 3" RELATED []
is_a: PR:000001068 ! transient receptor potential cation channel TRPV4

[Term]
id: PR:000001069
name: transient receptor potential cation channel TRPV4 isoform A
def: "A transient receptor potential cation channel TRPV4 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9HBA0-1 or a 1:1 ortholog thereof." [PMID:11025659, PMID:16293632, PRO:CNA, PRO:DAN]
comment: Category=sequence.
synonym: "A" RELATED []
synonym: "TRPV4-A" EXACT []
synonym: "TRPV4/iso:1" RELATED [PRO:DNx]
synonym: "TRPV4/iso:A" EXACT PRO-short-label [PRO:DNx]
synonym: "transient receptor potential cation channel TRPV4 isoform 1" RELATED []
is_a: PR:000001068 ! transient receptor potential cation channel TRPV4

[Term]
id: PR:000001068
name: transient receptor potential cation channel TRPV4
def: "A transient receptor potential cation channel TRPV that is a translation product of the human TRPV4 gene or a 1:1 ortholog thereof. The functional subunits are ion-selective calcium permeant cation channel probably involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification." [PRO:CNA, UniProtKB:Q9HBA0]
comment: Category=gene.
synonym: "VRL2" RELATED Gene-based []
synonym: "TRP12" EXACT []
synonym: "TRPV4" EXACT PRO-short-label [PRO:DNx]
synonym: "TrpV4" EXACT []
synonym: "VRL-2" EXACT []
synonym: "VROAC" RELATED Gene-based []
synonym: "OTRPC4" EXACT []
synonym: "VR-OAC" EXACT []
synonym: "Osm-9-like TRP channel 4" EXACT []
synonym: "vanilloid receptor-like channel 2" EXACT []
synonym: "vanilloid receptor-like protein 2" EXACT []
synonym: "transient receptor potential protein 12" EXACT []
synonym: "vanilloid receptor-related osmotically-activated channel" EXACT []
xref: IUPHARobj:510
is_a: PR:000000681 ! transient receptor potential cation channel TRPV

[Term]
id: PR:Q9HBA0-5
name: transient receptor potential cation channel subfamily V member 4 isoform D (human)
def: "A transient receptor potential cation channel TRPV4 isoform D that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q9HBA0]
comment: Category=organism-sequence.
synonym: "hTRPV4/iso:5" RELATED [PRO:DNx]
synonym: "hTRPV4/iso:D" EXACT PRO-short-label [PRO:DNx]
synonym: "transient receptor potential cation channel subfamily V member 4 isoform 5 (human)" EXACT [UniProtKB:Q9HBA0]
xref: UniProtKB:Q9HBA0-5
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000001072 ! transient receptor potential cation channel TRPV4 isoform D

[Term]
id: PR:Q9HBA0-4
name: transient receptor potential cation channel subfamily V member 4 isoform C (human)
def: "A transient receptor potential cation channel TRPV4 isoform C that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q9HBA0]
comment: Category=organism-sequence.
synonym: "hTRPV4/iso:4" RELATED [PRO:DNx]
synonym: "hTRPV4/iso:C" EXACT PRO-short-label [PRO:DNx]
synonym: "transient receptor potential cation channel subfamily V member 4 isoform 4 (human)" EXACT [UniProtKB:Q9HBA0]
xref: UniProtKB:Q9HBA0-4
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000001071 ! transient receptor potential cation channel TRPV4 isoform C