[Term]
id: PR:000001068
name: transient receptor potential cation channel TRPV4
def: "A transient receptor potential cation channel TRPV that is a translation product of the human TRPV4 gene or a 1:1 ortholog thereof. The functional subunits are ion-selective calcium permeant cation channel probably involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification." [PRO:CNA, UniProtKB:Q9HBA0]
comment: Category=gene.
synonym: "VRL2" RELATED Gene-based []
synonym: "TRP12" EXACT []
synonym: "TRPV4" EXACT PRO-short-label [PRO:DNx]
synonym: "TrpV4" EXACT []
synonym: "VRL-2" EXACT []
synonym: "VROAC" RELATED Gene-based []
synonym: "OTRPC4" EXACT []
synonym: "VR-OAC" EXACT []
synonym: "Osm-9-like TRP channel 4" EXACT []
synonym: "vanilloid receptor-like channel 2" EXACT []
synonym: "vanilloid receptor-like protein 2" EXACT []
synonym: "transient receptor potential protein 12" EXACT []
synonym: "vanilloid receptor-related osmotically-activated channel" EXACT []
xref: IUPHARobj:510
is_a: PR:000000681 ! transient receptor potential cation channel TRPV