[Term]
id: PR:000046653
name: T-cell surface glycoprotein CD8 alpha chain, signal peptide removed form (human)
def: "A T-cell surface glycoprotein CD8 alpha chain (human) that has had the signal peptide removed. UniProtKB:P01732, 22-235." [PRO:DNx, Reactome:R-HSA-197601]
comment: Category=organism-modification.
synonym: "hCD8A/SigPep-" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000014638" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P01732, 22-235" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-197601 "PR:000046653 located_in GO:0005886"
intersection_of: PR:P01732 ! T-cell surface glycoprotein CD8 alpha chain (human)
intersection_of: lacks_part SO:0000418 ! signal_peptide
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000052043
name: T-cell surface glycoprotein CD8 alpha chain O-glycosylated 2 (human)
def: "A T-cell surface glycoprotein CD8 alpha chain (human) that has been O-glycosylated at the residue equivalent to Ser-158 of the amino acid sequence represented by UniProtKB:P01732-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P01732-1, Ser-158, MOD:00002~GNO:G43417UB." [GlyGen:P01732-1, PMID:30459171, PRO:DNx]
comment: Category=organism-modification. Requested by=GlyGen.
synonym: "hCD8A/OGlyco:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P01732-1, Ser-158, MOD:00002~GNO:G43417UB" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P01732 ! T-cell surface glycoprotein CD8 alpha chain (human)
relationship: has_part GNO:G43417UB ! G43417UB
relationship: has_part MOD:00002 ! O-glycosyl-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000052042
name: T-cell surface glycoprotein CD8 alpha chain O-glycosylated 1 (human)
def: "A T-cell surface glycoprotein CD8 alpha chain (human) that has been O-glycosylated at the residue equivalent to Ser-158 of the amino acid sequence represented by UniProtKB:P01732-1, in which the glycan composition is represented by GlyTouCan:G29068FM. Example: UniProtKB:P01732-1, Ser-158, MOD:00002~GNO:G29068FM." [GlyGen:P01732-1, PMID:30459171, PRO:DNx]
comment: Category=organism-modification. Requested by=GlyGen.
synonym: "hCD8A/OGlyco:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P01732-1, Ser-158, MOD:00002~GNO:G29068FM" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P01732 ! T-cell surface glycoprotein CD8 alpha chain (human)
relationship: has_part GNO:G29068FM ! G29068FM
relationship: has_part MOD:00002 ! O-glycosyl-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P01732
name: T-cell surface glycoprotein CD8 alpha chain (human)
def: "A T-cell surface glycoprotein CD8 alpha chain that is encoded in the genome of human." [PRO:CNA, UniProtKB:P01732]
comment: Category=organism-gene.
synonym: "MAL" RELATED Gene-based [UniProtKB:P01732]
synonym: "CD8A" RELATED Gene-based [UniProtKB:P01732]
synonym: "hCD8A" EXACT PRO-short-label [PRO:DNx]
synonym: "CD8a (human)" EXACT [UniProtKB:P01732]
synonym: "T-lymphocyte differentiation antigen T8/Leu-2 (human)" EXACT [UniProtKB:P01732]
xref: UniProtKB:P01732
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain
relationship: has_gene_template HGNC:1706 ! CD8A (human)

[Term]
id: PR:P01732-3
name: T-cell surface glycoprotein CD8 alpha chain isoform h3 (human)
def: "A T-cell surface glycoprotein CD8 alpha chain (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P01732-3." [PRO:DNx, UniProtKB:P01732]
comment: Category=organism-sequence.
synonym: "hCD8A/iso:h3" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P01732-3
is_a: PR:P01732 ! T-cell surface glycoprotein CD8 alpha chain (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P01732-2
name: T-cell surface glycoprotein CD8 alpha chain isoform 2 (human)
def: "A T-cell surface glycoprotein CD8 alpha chain isoform 2 that is encoded in the genome of human." [PRO:DAN]
comment: Category=organism-sequence.
synonym: "hCD8A/iso:2" EXACT PRO-short-label [PRO:DNx]
synonym: "T-cell surface glycoprotein CD8 alpha chain isoform secreted (human)" EXACT [UniProtKB:P01732]
synonym: "T-cell surface glycoprotein CD8 alpha chain isoform sCD8alpha (human)" EXACT [UniProtKB:P01732]
xref: UniProtKB:P01732-2
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000025404 ! T-cell surface glycoprotein CD8 alpha chain isoform 2

[Term]
id: PR:P01732-1
name: T-cell surface glycoprotein CD8 alpha chain isoform 1 (human)
def: "A T-cell surface glycoprotein CD8 alpha chain isoform 1 that is encoded in the genome of human." [PRO:DAN]
comment: Category=organism-sequence.
synonym: "hCD8A/iso:1" EXACT PRO-short-label [PRO:DNx]
synonym: "T-cell surface glycoprotein CD8 alpha chain isoform membrane (human)" EXACT [UniProtKB:P01732]
synonym: "T-cell surface glycoprotein CD8 alpha chain isoform mCD8alpha (human)" EXACT [UniProtKB:P01732]
xref: UniProtKB:P01732-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000025403 ! T-cell surface glycoprotein CD8 alpha chain isoform 1

[Term]
id: PR:000001084
name: T-cell surface glycoprotein CD8 alpha chain
def: "A protein that is a translation product of the human CD8A gene or a 1:1 ortholog thereof. CD8 is a transmembrane that is a co-receptor for MHC class-I antigen/T-cell receptor interaction. The most common form of CD8 is composed of a CD8 alpha and a CD8 beta chain." [PMID:11114424, PRO:CNA, Wikipedia:CD8]
comment: Category=gene. Requested by=CL.
synonym: "MAL" RELATED Gene-based []
synonym: "CD8A" EXACT PRO-short-label [PRO:DNx]
synonym: "CD8a" EXACT []
synonym: "Lyt2" RELATED Gene-based []
synonym: "Lyt-2" RELATED Gene-based []
synonym: "T-cell surface glycoprotein Lyt-2" EXACT []
synonym: "T-lymphocyte differentiation antigen T8/Leu-2" EXACT []
is_a: PR:000000001 ! protein