[Term] id: PR:P23631 name: alpha-latrotoxin-Lt1a (Latrodectus tredecimguttatus) def: "An alpha-latrotoxin that is encoded in the genome of Latrodectus tredecimguttatus." [PRO:CNA] comment: Category=organism-gene. synonym: "alpha-LTX-Lt1a" EXACT [UniProtKB:P23631] synonym: "alpha-LTX (LATTR)" EXACT PRO-short-label [PRO:DNx] synonym: "alpha-LTX (Latrodectus tredecimguttatus)" EXACT [UniProtKB:P23631] synonym: "alpha-latrotoxin (Latrodectus tredecimguttatus)" EXACT [UniProtKB:P23631] xref: UniProtKB:P23631 intersection_of: only_in_taxon NCBITaxon:6925 ! Latrodectus tredecimguttatus intersection_of: PR:000001088 ! alpha-latrotoxin [Term] id: PR:000025413 name: alpha-latrotoxin proteolytic cleavage product def: "An alpha-latrotoxin that has been processed by proteolytic cleavage." [PRO:DNx] comment: Category=modification. synonym: "alpha-LTX/ClvPrd" EXACT PRO-short-label [PRO:DNx] intersection_of: output_of GO:0016485 ! protein processing intersection_of: PR:000001088 ! alpha-latrotoxin [Term] id: PR:000001250 name: alpha-latrotoxin isoform 1, signal peptide removed form def: "An alpha-latrotoxin isoform 1 that has had the signal peptide removed to yield the secreted form." [PRO:CNA] comment: Category=modification. synonym: "alpha-LTX/iso:1/SigPep-" EXACT PRO-short-label [PRO:DNx] synonym: "alpha-latrotoxin isoform 1 cleaved 1" EXACT [] intersection_of: PR:000001117 ! alpha-latrotoxin isoform 1 intersection_of: lacks_part SO:0000418 ! signal_peptide [Term] id: PR:000001117 name: alpha-latrotoxin isoform 1 def: "An alpha-latrotoxin that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P23631-1 or a 1:1 ortholog thereof." [PRO:CNA] comment: Category=sequence. synonym: "alpha-LTX/iso:1" EXACT PRO-short-label [PRO:DNx] is_a: PR:000001088 ! alpha-latrotoxin [Term] id: PR:000001088 name: alpha-latrotoxin def: "A protein that is a constituent neurotoxin of (for example) black widow spider venom, and contains multiple ankyrin repeats (20-22)." [PMID:18064415, PMID:1888339, PRO:CNA, PRO:DAN] comment: Category=gene. Note: The active form assembles into homotetrameric complexes which harbor a central channel and can insert into target lipid membranes, but relies on the binding to specific receptors in the plasma membrane to exert its function. synonym: "alpha-LTX" EXACT PRO-short-label [PRO:DNx] is_a: PR:000000001 ! protein [Term] id: PR:P23631-1 name: alpha-latrotoxin-Lt1a isoform 1 (Latrodectus tredecimguttatus) def: "An alpha-latrotoxin isoform 1 that is encoded in the genome of Latrodectus tredecimguttatus." [PRO:CNA] comment: Category=organism-sequence. synonym: "alpha-LTX/iso:1 (LATTR)" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P23631-1 intersection_of: only_in_taxon NCBITaxon:6925 ! Latrodectus tredecimguttatus intersection_of: PR:000001117 ! alpha-latrotoxin isoform 1