[Term] id: PR:P01583-1 name: interleukin-1 alpha isoform 1 (human) def: "An interleukin-1 alpha isoform 1 that is encoded in the genome of human." [PRO:CNA] comment: Category=organism-sequence. synonym: "hIL1A/iso:1" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P01583-1 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000001227 ! interleukin-1 alpha isoform 1 [Term] id: PR:P16598 name: interleukin-1 alpha (rat) def: "An interleukin-1 alpha that is encoded in the genome of rat." [OMA:P16598, PANTHER:PTHR11420:SF0, PRO:DNx] comment: Category=organism-gene. synonym: "Il1a" RELATED Gene-based [UniProtKB:P16598] synonym: "rIL1A" EXACT PRO-short-label [PRO:DNx] synonym: "IL-1 alpha (rat)" EXACT [UniProtKB:P16598] xref: UniProtKB:P16598 intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus intersection_of: PR:000001135 ! interleukin-1 alpha relationship: has_gene_template RGD:2890 ! Il1a (rat) [Term] id: PR:000036600 name: interleukin-1 alpha isoform 1 phosphorylated 1 (mouse) def: "An interleukin-1 alpha isoform 1 phosphorylated 1 in mouse. UniProtKB:P01582-1, Ser-90, MOD:00046." [PMID:3126184, PRO:CNA] comment: Category=organism-modification. synonym: "mIL1A/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P01582-1, Ser-90, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx] intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus intersection_of: PR:000001270 ! interleukin-1 alpha isoform 1 phosphorylated 1 relationship: has_part MOD:00046 ! O-phospho-L-serine [Term] id: PR:000045524 name: interleukin-1 alpha isoform 1 cleaved 1 (mouse) def: "An interleukin-1 alpha isoform 1 cleaved 1 in mouse. UniProtKB:P01582-1, 115-270." [PMID:23395675, PRO:HJD, UniProtKB:P01582] comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:23395675). synonym: "PRO_0000015274" EXACT PRO-proteoform-ftid [PRO:DNx] synonym: "mIL1A/iso:1/Clv:1" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P01582-1, 115-270" EXACT PRO-proteoform-std [PRO:DNx] intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus intersection_of: PR:000001267 ! interleukin-1 alpha isoform 1 cleaved 1 [Term] id: PR:000001227 name: interleukin-1 alpha isoform 1 def: "An interleukin-1 alpha that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P01583-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN] comment: Category=sequence. synonym: "IL1A/iso:1" EXACT PRO-short-label [PRO:DNx] is_a: PR:000001135 ! interleukin-1 alpha [Term] id: PR:P01582-1 name: interleukin-1 alpha isoform 1 (mouse) def: "An interleukin-1 alpha isoform 1 that is encoded in the genome of mouse." [PRO:CNA] comment: Category=organism-sequence. synonym: "mIL1A/iso:1" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P01582-1 intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus intersection_of: PR:000001227 ! interleukin-1 alpha isoform 1 [Term] id: PR:000045525 name: interleukin-1 alpha isoform 1 precursor (mouse) def: "An interleukin-1 alpha isoform 1 (mouse) that has not been subjected to any proteolytic cleavage. UniProtKB:P01582-1, 1-270." [PMID:23395675, PRO:HJD, UniProtKB:P01582] comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:23395675). synonym: "mIl1a/iso:1/Full" EXACT PRO-short-label [PRO:DAN] synonym: "pro-IL-1alpha (mouse)" RELATED [] synonym: "UniProtKB:P01582-1, 1-270" EXACT PRO-proteoform-std [PRO:DAN] is_a: PR:P01582-1 ! interleukin-1 alpha isoform 1 (mouse) relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus relationship: has_part SO:0001062 ! propeptide [Term] id: PR:000001267 name: interleukin-1 alpha isoform 1 cleaved 1 def: "An interleukin-1 alpha isoform 1 that has had the propeptide removed. This is the mature peptide." [PRO:CNA, PRO:DAN] comment: Category=modification. synonym: "IL1A/iso:1/Clv:1" EXACT PRO-short-label [PRO:DNx] intersection_of: PR:000001227 ! interleukin-1 alpha isoform 1 intersection_of: lacks_part SO:0001062 ! propeptide [Term] id: PR:000036599 name: interleukin-1 alpha isoform 1 myristoylated 2 (human) def: "An interleukin-1 alpha isoform 1 myristoylated 2 in human. UniProtKB:P01583-1, Lys-82, MOD:00087." [PMID:8346241, PRO:CNA] comment: Category=organism-modification. synonym: "hIL1A/iso:1/Myr:2" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P01583-1, Lys-82, MOD:00087" EXACT PRO-proteoform-std [PRO:DNx] intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000001269 ! interleukin-1 alpha isoform 1 myristoylated 2 relationship: has_part MOD:00087 ! N6-myristoyl-L-lysine [Term] id: PR:000036598 name: interleukin-1 alpha isoform 1 myristoylated 1 (human) def: "An interleukin-1 alpha isoform 1 myristoylated 1 in human. UniProtKB:P01583-1, Lys-83, MOD:00087." [PMID:8346241, PRO:CNA] comment: Category=organism-modification. synonym: "hIL1A/iso:1/Myr:1" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P01583-1, Lys-83, MOD:00087" EXACT PRO-proteoform-std [PRO:DNx] intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000001268 ! interleukin-1 alpha isoform 1 myristoylated 1 relationship: has_part MOD:00087 ! N6-myristoyl-L-lysine [Term] id: PR:000001270 name: interleukin-1 alpha isoform 1 phosphorylated 1 def: "An interleukin-1 alpha isoform 1 phosphorylated form in which the phosphorylation occurs at a Ser residue within the propeptide region. Example: UniProtKB:P01582-1, Ser-90, MOD:00046." [PMID:3126184, PMID:3258335] comment: Category=modification. synonym: "IL1A/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx] is_a: PR:000001260 ! interleukin-1 alpha isoform 1 phosphorylated form relationship: has_part MOD:00046 ! O-phospho-L-serine [Term] id: PR:000001260 name: interleukin-1 alpha isoform 1 phosphorylated form def: "An interleukin-1 alpha isoform 1 that includes at least one phosphorylated residue." [PRO:CNA] comment: Category=modification. synonym: "IL1A/iso:1/PhosRes+" EXACT PRO-short-label [PRO:DNx] intersection_of: has_part MOD:00696 ! phosphorylated residue intersection_of: PR:000001227 ! interleukin-1 alpha isoform 1 [Term] id: PR:P01583 name: interleukin-1 alpha (human) def: "An interleukin-1 alpha that is encoded in the genome of human." [PRO:CNA, UniProtKB:P01583] comment: Category=organism-gene. synonym: "IL1A" RELATED Gene-based [UniProtKB:P01583] synonym: "IL1F1" RELATED Gene-based [UniProtKB:P01583] synonym: "hIL1A" EXACT PRO-short-label [PRO:DNx] synonym: "IL-1 alpha (human)" EXACT [UniProtKB:P01583] synonym: "hematopoietin-1 (human)" EXACT [UniProtKB:P01583] xref: Reactome:R-HSA-449042 "PR:P01583 located_in GO:0005829" xref: UniProtKB:P01583 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000001135 ! interleukin-1 alpha relationship: has_gene_template HGNC:5991 ! IL1A (human) [Term] id: PR:P01582 name: interleukin-1 alpha (mouse) def: "An interleukin-1 alpha that is encoded in the genome of mouse." [OMA:P01582, PRO:DNx] comment: Category=organism-gene. synonym: "Il1a" RELATED Gene-based [UniProtKB:P01582] synonym: "mIL1A" EXACT PRO-short-label [PRO:DNx] synonym: "IL-1 alpha (mouse)" EXACT [UniProtKB:P01582] xref: UniProtKB:P01582 intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus intersection_of: PR:000001135 ! interleukin-1 alpha relationship: has_gene_template MGI:96542 ! Il1a (mouse) [Term] id: PR:000001135 name: interleukin-1 alpha def: "An interleukin-1 that is a translation product of the human IL1A gene or a 1:1 ortholog thereof. Critical mediator of the immune and inflammatory responses." [PRO:CNA, Wikipedia:Interleukin_1] comment: Category=gene. synonym: "IL1A" EXACT PRO-short-label [PRO:DNx] synonym: "IL1F1" RELATED Gene-based [] synonym: "IL-1 alpha" EXACT [] synonym: "hematopoietin-1" EXACT [] is_a: PR:000001091 ! interleukin-1 [Term] id: PR:000001259 name: interleukin-1 alpha isoform 1 myristoylated form def: "An interleukin-1 alpha isoform 1 that includes at least one myristoylated residue." [PRO:CNA] comment: Category=modification. synonym: "IL1A/iso:1/MyrRes+" EXACT PRO-short-label [PRO:DNx] intersection_of: has_part MOD:00438 ! myristoylated residue intersection_of: PR:000001227 ! interleukin-1 alpha isoform 1 [Term] id: PR:000036597 name: interleukin-1 alpha isoform 1 cleaved 1 (human) def: "An interleukin-1 alpha isoform 1 cleaved 1 in human. UniProtKB:P01583-1, 113-271." [PMID:3281727, PRO:CNA] comment: Category=organism-modification. synonym: "PRO_0000015266" EXACT PRO-proteoform-ftid [PRO:DNx] synonym: "hIL1A/iso:1/Clv:1" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P01583-1, 113-271" EXACT PRO-proteoform-std [PRO:DNx] intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000001267 ! interleukin-1 alpha isoform 1 cleaved 1 [Term] id: PR:000018344 name: interleukin-1 alpha proteolytic cleavage product def: "An interleukin-1 alpha that has been processed by proteolytic cleavage." [PRO:DNx] comment: Category=modification. synonym: "IL1A/ClvPrd" EXACT PRO-short-label [PRO:DNx] intersection_of: output_of GO:0016485 ! protein processing intersection_of: PR:000001135 ! interleukin-1 alpha [Term] id: PR:000001269 name: interleukin-1 alpha isoform 1 myristoylated 2 def: "An interleukin-1 alpha isoform 1 myristoylated form with an N6-myristoyl Lys residue in the first Lys of the propeptide region. Example: UniProtKB:P01583-1, Lys-82, MOD:00087." [PMID:8346241] comment: Category=modification. synonym: "IL1A/iso:1/Myr:2" EXACT PRO-short-label [PRO:DNx] is_a: PR:000001259 ! interleukin-1 alpha isoform 1 myristoylated form relationship: has_part MOD:00087 ! N6-myristoyl-L-lysine [Term] id: PR:000001268 name: interleukin-1 alpha isoform 1 myristoylated 1 def: "An interleukin-1 alpha isoform 1 myristoylated form with an N6-myristoyl Lys residue in the second Lys of the propeptide region. Example: UniProtKB:P01583-1, Lys-83, MOD:00087." [PMID:8346241] comment: Category=modification. synonym: "IL1A/iso:1/Myr:1" EXACT PRO-short-label [PRO:DNx] is_a: PR:000001259 ! interleukin-1 alpha isoform 1 myristoylated form relationship: has_part MOD:00087 ! N6-myristoyl-L-lysine