[Term]
id: PR:000049472
name: Toll-like receptor 9, signal peptide removed form (human)
def: "A Toll-like receptor 9 (human) that has had the signal peptide removed. UniProtKB:Q9NR96, 26-1032." [PRO:DNx, Reactome:R-HSA-1678961, Reactome:R-HSA-1678997, Reactome:R-HSA-167979, Reactome:R-HSA-187882]
comment: Category=organism-modification.
synonym: "hTLR9/SigPep-" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000034737" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:Q9NR96, 26-1032" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-167979 "PR:000049472 located_in GO:0036020"
xref: Reactome:R-HSA-187882 "PR:000049472 located_in GO:0010008"
xref: Reactome:R-HSA-1678961 "PR:000049472 located_in GO:0005789"
xref: Reactome:R-HSA-1678997 "PR:000049472 located_in GO:0000139"
intersection_of: PR:Q9NR96 ! Toll-like receptor 9 (human)
intersection_of: lacks_part SO:0000418 ! signal_peptide
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q9NR96-3
name: Toll-like receptor 9 isoform h3 (human)
def: "A Toll-like receptor 9 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9NR96-3." [PRO:DNx, UniProtKB:Q9NR96]
comment: Category=organism-sequence.
synonym: "hTLR9/iso:h3" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q9NR96-3
is_a: PR:Q9NR96 ! Toll-like receptor 9 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q9NR96
name: Toll-like receptor 9 (human)
def: "A Toll-like receptor 9 that is encoded in the genome of human." []
comment: Category=organism-gene.
synonym: "TLR9" RELATED Gene-based [UniProtKB:Q9NR96]
synonym: "hTLR9" EXACT PRO-short-label [PRO:DNx]
synonym: "CD289 (human)" EXACT [UniProtKB:Q9NR96]
synonym: "UNQ5798/PRO19605" RELATED Gene-based [UniProtKB:Q9NR96]
xref: Reactome:R-HSA-1678982 "PR:Q9NR96 located_in GO:0036020"
xref: Reactome:R-HSA-1679580 "PR:Q9NR96 located_in GO:0010008"
xref: UniProtKB:Q9NR96
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000001160 ! Toll-like receptor 9
relationship: has_gene_template HGNC:15633 ! TLR9 (human)

[Term]
id: PR:000001160
name: Toll-like receptor 9
def: "A Toll-like receptor that is a translation product of the human TLR9 gene or a 1:1 ortholog thereof. Non-methylated CpG motifs, present in viral and bacterial DNA, are one of many pathogen-associated molecular patterns (PAMP) recognized by the mammalian innate immune system. Recognition of this PAMP occurs through a specific interaction with Toll-like receptor 9 and this interaction can induce cytokine responses that influence both innate and adaptive immune responses." [PMID:11022119]
comment: Category=gene.
synonym: "TLR9" EXACT PRO-short-label [PRO:DNx]
synonym: "CD289" EXACT []
synonym: "UNQ5798/PRO19605" RELATED Gene-based []
xref: IUPHARobj:1759
is_a: PR:000001096 ! Toll-like receptor

[Term]
id: PR:Q9NR96-2
name: Toll-like receptor 9 isoform h2 (human)
def: "A Toll-like receptor 9 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9NR96-2." [PRO:DNx, UniProtKB:Q9NR96]
comment: Category=organism-sequence.
synonym: "hTLR9/iso:h2" EXACT PRO-short-label [PRO:DNx]
synonym: "Toll-like receptor 9 isoform B (human)" EXACT [UniProtKB:Q9NR96]
xref: UniProtKB:Q9NR96-2
is_a: PR:Q9NR96 ! Toll-like receptor 9 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q9NR96-1
name: Toll-like receptor 9 isoform h1 (human)
def: "A Toll-like receptor 9 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9NR96-1." [PRO:DNx, UniProtKB:Q9NR96]
comment: Category=organism-sequence.
synonym: "hTLR9/iso:h1" EXACT PRO-short-label [PRO:DNx]
synonym: "Toll-like receptor 9 isoform A (human)" EXACT [UniProtKB:Q9NR96]
xref: UniProtKB:Q9NR96-1
is_a: PR:Q9NR96 ! Toll-like receptor 9 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q9NR96-5
name: Toll-like receptor 9 isoform h5 (human)
def: "A Toll-like receptor 9 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9NR96-5." [PRO:DNx, UniProtKB:Q9NR96]
comment: Category=organism-sequence.
synonym: "hTLR9/iso:h5" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q9NR96-5
is_a: PR:Q9NR96 ! Toll-like receptor 9 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q9NR96-4
name: Toll-like receptor 9 isoform h4 (human)
def: "A Toll-like receptor 9 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9NR96-4." [PRO:DNx, UniProtKB:Q9NR96]
comment: Category=organism-sequence.
synonym: "hTLR9/iso:h4" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q9NR96-4
is_a: PR:Q9NR96 ! Toll-like receptor 9 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens