[Term] id: PR:000001221 name: endothelin-1 receptor def: "An endothelin receptor that is a translation product of the human EDNRA gene or a 1:1 ortholog thereof. The active form binds endothelin 1 (ET-1) and ET-2 with much higher affinity than ET-3." [PMID:12037137, PRO:WCB] comment: Category=gene. synonym: "ETA" RELATED Gene-based [] synonym: "ET-A" BROAD [PRO:DNx] synonym: "ETRA" RELATED Gene-based [] synonym: "EDNRA" EXACT PRO-short-label [PRO:DNx] synonym: "ET-AR" EXACT [] synonym: "ETA-R" EXACT [] synonym: "Gpcr10" RELATED Gene-based [] synonym: "endothelin A receptor" EXACT [] synonym: "endothelin receptor A" EXACT [] synonym: "endothelin receptor type A" EXACT [] xref: IUPHARobj:219 is_a: PR:000001133 ! endothelin receptor [Term] id: PR:P25101-5 name: endothelin-1 receptor isoform h5 (human) def: "An endothelin-1 receptor (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P25101-5." [PRO:DNx, UniProtKB:P25101] comment: Category=organism-sequence. synonym: "hEDNRA/iso:h5" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P25101-5 is_a: PR:P25101 ! endothelin-1 receptor (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:P25101-4 name: endothelin-1 receptor isoform h4 (human) def: "An endothelin-1 receptor (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P25101-4." [PRO:DNx, UniProtKB:P25101] comment: Category=organism-sequence. synonym: "hEDNRA/iso:h4" EXACT PRO-short-label [PRO:DNx] synonym: "endothelin-1 receptor isoform Delta-3,4 (human)" EXACT [UniProtKB:P25101] xref: UniProtKB:P25101-4 is_a: PR:P25101 ! endothelin-1 receptor (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:P25101-1 name: endothelin-1 receptor isoform 1 (human) def: "An endothelin-1 receptor isoform 1 that is encoded in the genome of human." [PRO:DNx] comment: Category=organism-sequence. synonym: "hEDNRA/iso:1" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P25101-1 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000039131 ! endothelin-1 receptor isoform 1 [Term] id: PR:P25101-3 name: endothelin-1 receptor isoform h3 (human) def: "An endothelin-1 receptor (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P25101-3." [PRO:DNx, UniProtKB:P25101] comment: Category=organism-sequence. synonym: "hEDNRA/iso:h3" EXACT PRO-short-label [PRO:DNx] synonym: "endothelin-1 receptor isoform Delta-4 (human)" EXACT [UniProtKB:P25101] xref: UniProtKB:P25101-3 is_a: PR:P25101 ! endothelin-1 receptor (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:P25101-2 name: endothelin-1 receptor isoform h2 (human) def: "An endothelin-1 receptor (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P25101-2." [PRO:DNx, UniProtKB:P25101] comment: Category=organism-sequence. synonym: "hEDNRA/iso:h2" EXACT PRO-short-label [PRO:DNx] synonym: "endothelin-1 receptor isoform Delta-3 (human)" EXACT [UniProtKB:P25101] xref: UniProtKB:P25101-2 is_a: PR:P25101 ! endothelin-1 receptor (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:P25101 name: endothelin-1 receptor (human) def: "An endothelin-1 receptor that is encoded in the genome of human." [PRO:WCB, UniProtKB:P25101] comment: Category=organism-gene. synonym: "ETA" RELATED Gene-based [UniProtKB:P25101] synonym: "ETRA" RELATED Gene-based [UniProtKB:P25101] synonym: "EDNRA" RELATED Gene-based [UniProtKB:P25101] synonym: "hEDNRA" EXACT PRO-short-label [PRO:DNx] synonym: "hET-AR" EXACT [UniProtKB:P25101] synonym: "ET-A (human)" EXACT [UniProtKB:P25101] synonym: "ETA-R (human)" EXACT [UniProtKB:P25101] synonym: "endothelin receptor type A (human)" EXACT [UniProtKB:P25101] xref: DTO:02100086 xref: UniProtKB:P25101 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000001221 ! endothelin-1 receptor relationship: has_gene_template HGNC:3179 ! EDNRA (human) [Term] id: PR:000047245 name: endothelin-1 receptor, signal peptide removed form (human) def: "An endothelin-1 receptor (human) that has had the signal peptide removed. UniProtKB:P25101, 21-427." [PRO:DNx, Reactome:R-HSA-388549] comment: Category=organism-modification. synonym: "PRO_0000012721" EXACT PRO-proteoform-ftid [PRO:DNx] synonym: "hEDNRA/SigPep-" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P25101, 21-427" EXACT PRO-proteoform-std [PRO:DNx] xref: Reactome:R-HSA-388549 "PR:000047245 located_in GO:0005886" intersection_of: PR:P25101 ! endothelin-1 receptor (human) intersection_of: lacks_part SO:0000418 ! signal_peptide relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens