[Term]
id: PR:000001291
name: C-type asialoglycoprotein receptor
def: "A protein that is an integral membrane protein and is responsible for the clearance of desialylated, galactose-terminal glycoproteins from the circulation by receptor-mediated endocytosis. It can be subdivided into four functional domains: the cytosolic domain, the transmembrane domain, the stalk and the carbohydrate recognition domain (CRD). The functional receptor, a galactose lectin, is an oligomer of two types of similar polypeptide chains, each of which weakly binds galactose. High-affinity binding of complex oligosaccharides requires a precise geometric arrangement of receptor subunits. The two subunits have different functions in receptor assembly, ligand binding and endocytosis." [PMID:10891274, PMID:1785139]
comment: Category=family.
xref: PIRSF:PIRSF002424
is_a: PR:000000001 ! protein