[Term]
id: PR:000001333
name: cation-independent mannose-6-phosphate receptor
def: "A protein that is a translation product of the human IGF2R gene or a 1:1 ortholog thereof." [PRO:WCB]
comment: Category=gene.
synonym: "M6PR" BROAD [PRO:DNx]
synonym: "MPRI" RELATED Gene-based []
synonym: "CD222" EXACT []
synonym: "IGF2R" EXACT PRO-short-label [PRO:DNx]
synonym: "CI-MPR" EXACT []
synonym: "MPR 300" EXACT []
synonym: "M6P/IGF2R" EXACT []
synonym: "IGF-II receptor" EXACT []
synonym: "M6P/IGF2 receptor" EXACT []
synonym: "CI Man-6-P receptor" EXACT []
synonym: "300 kDa mannose 6-phosphate receptor" EXACT []
synonym: "insulin-like growth factor 2 receptor" EXACT []
synonym: "insulin-like growth factor II receptor" EXACT []
xref: PIRSF:PIRSF036993
is_a: PR:000000001 ! protein

[Term]
id: PR:P11717
name: cation-independent mannose-6-phosphate receptor (human)
def: "A cation-independent mannose-6-phosphate receptor that is encoded in the genome of human." [PRO:WCB, UniProtKB:P11717]
comment: Category=organism-gene.
synonym: "MPRI" RELATED Gene-based [UniProtKB:P11717]
synonym: "IGF2R" RELATED Gene-based [UniProtKB:P11717]
synonym: "hIGF2R" EXACT PRO-short-label [PRO:DNx]
synonym: "M6PR (human)" EXACT [UniProtKB:P11717]
synonym: "CD222 (human)" EXACT [UniProtKB:P11717]
synonym: "CI-MPR (human)" EXACT [UniProtKB:P11717]
synonym: "MPR 300 (human)" EXACT [UniProtKB:P11717]
synonym: "M6P/IGF2R (human)" EXACT [UniProtKB:P11717]
synonym: "IGF-II receptor (human)" EXACT [UniProtKB:P11717]
synonym: "M6P/IGF2 receptor (human)" EXACT [UniProtKB:P11717]
synonym: "CI Man-6-P receptor (human)" EXACT [UniProtKB:P11717]
synonym: "300 kDa mannose 6-phosphate receptor (human)" EXACT [UniProtKB:P11717]
synonym: "insulin-like growth factor 2 receptor (human)" EXACT [UniProtKB:P11717]
synonym: "insulin-like growth factor II receptor (human)" EXACT [UniProtKB:P11717]
xref: UniProtKB:P11717
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000001333 ! cation-independent mannose-6-phosphate receptor
relationship: has_gene_template HGNC:5467 ! IGF2R (human)

[Term]
id: PR:Q07113
name: cation-independent mannose-6-phosphate receptor (mouse)
def: "A cation-independent mannose-6-phosphate receptor that is encoded in the genome of mouse." [OMA:Q07113, PRO:DNx]
comment: Category=organism-gene.
synonym: "Igf2r" RELATED Gene-based [UniProtKB:Q07113]
synonym: "mIGF2R" EXACT PRO-short-label [PRO:DNx]
synonym: "M6PR (mouse)" EXACT [UniProtKB:Q07113]
synonym: "CD222 (mouse)" EXACT [UniProtKB:Q07113]
synonym: "CI-MPR (mouse)" EXACT [UniProtKB:Q07113]
synonym: "MPR 300 (mouse)" EXACT [UniProtKB:Q07113]
synonym: "M6P/IGF2R (mouse)" EXACT [UniProtKB:Q07113]
synonym: "IGF-II receptor (mouse)" EXACT [UniProtKB:Q07113]
synonym: "M6P/IGF2 receptor (mouse)" EXACT [UniProtKB:Q07113]
synonym: "CI Man-6-P receptor (mouse)" EXACT [UniProtKB:Q07113]
synonym: "300 kDa mannose 6-phosphate receptor (mouse)" EXACT [UniProtKB:Q07113]
synonym: "insulin-like growth factor 2 receptor (mouse)" EXACT [UniProtKB:Q07113]
synonym: "insulin-like growth factor II receptor (mouse)" EXACT [UniProtKB:Q07113]
xref: UniProtKB:Q07113
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000001333 ! cation-independent mannose-6-phosphate receptor
relationship: has_gene_template MGI:96435 ! Igf2r (mouse)

[Term]
id: PR:000018408
name: cation-independent mannose-6-phosphate receptor, signal peptide removed form
def: "A cation-independent mannose-6-phosphate receptor that has had the signal peptide removed." [PRO:DNx]
comment: Category=modification.
synonym: "IGF2R/SigPep-" EXACT PRO-short-label [PRO:DNx]
intersection_of: PR:000001333 ! cation-independent mannose-6-phosphate receptor
intersection_of: lacks_part SO:0000418 ! signal_peptide

[Term]
id: PR:000047971
name: cation-independent mannose-6-phosphate receptor, signal peptide removed form (human)
def: "A cation-independent mannose-6-phosphate receptor (human) that has had the signal peptide removed. UniProtKB:P11717, 41-2491." [PRO:DNx, Reactome:R-HSA-434213, Reactome:R-HSA-434345, Reactome:R-HSA-6806532, Reactome:R-HSA-6814608, Reactome:R-HSA-6814609, Reactome:R-HSA-8869091]
comment: Category=organism-modification.
synonym: "PRO_0000019229" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "hIGF2R/SigPep-" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P11717, 41-2491" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-434213 "PR:000047971 located_in GO:0030659"
xref: Reactome:R-HSA-434345 "PR:000047971 located_in GO:0000139"
xref: Reactome:R-HSA-6803320 "PR:000047971 located_in GO:0030667"
xref: Reactome:R-HSA-6806532 "PR:000047971 located_in GO:0005886"
xref: Reactome:R-HSA-6814608 "PR:000047971 located_in GO:0032588"
xref: Reactome:R-HSA-6814609 "PR:000047971 located_in GO:0030133"
xref: Reactome:R-HSA-8869091 "PR:000047971 located_in GO:0030665"
intersection_of: PR:P11717 ! cation-independent mannose-6-phosphate receptor (human)
intersection_of: lacks_part SO:0000418 ! signal_peptide
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000054953
name: cation-independent mannose-6-phosphate receptor O-glycosylated 1 (human)
def: "A cation-independent mannose-6-phosphate receptor (human) that has been O-glycosylated at the residue equivalent to Thr-770 of the amino acid sequence represented by UniProtKB:P11717-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P11717-1, Thr-770, MOD:00005~GNO:G43417UB." [GlyGen:P11717-1, PMID:30459171, PRO:DNx]
comment: Category=organism-modification. Requested by=GlyGen.
synonym: "hIGF2R/OGlyco:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P11717-1, Thr-770, MOD:00005~GNO:G43417UB" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P11717 ! cation-independent mannose-6-phosphate receptor (human)
relationship: has_part GNO:G43417UB ! G43417UB
relationship: has_part MOD:00005 ! O-glycosyl-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000054952
name: cation-independent mannose-6-phosphate receptor N-glycosylated 3 (human)
def: "A cation-independent mannose-6-phosphate receptor (human) that has been N-glycosylated at the residue equivalent to Asn-1312 of the amino acid sequence represented by UniProtKB:P11717-1, in which the glycan composition is represented by GlyTouCan:G83633GK. Example: UniProtKB:P11717-1, Asn-1312, MOD:00160~GNO:G83633GK." [GlyGen:P11717-1, PMID:29741879, PRO:DNx]
comment: Category=organism-modification. Requested by=GlyGen.
synonym: "hIGF2R/NGlyco:3" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P11717-1, Asn-1312, MOD:00160~GNO:G83633GK" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P11717 ! cation-independent mannose-6-phosphate receptor (human)
relationship: has_part GNO:G83633GK ! G83633GK
relationship: has_part MOD:00160 ! N4-glycosyl-L-asparagine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000054951
name: cation-independent mannose-6-phosphate receptor N-glycosylated 2 (human)
def: "A cation-independent mannose-6-phosphate receptor (human) that has been N-glycosylated at the residue equivalent to Asn-1312 of the amino acid sequence represented by UniProtKB:P11717-1, in which the glycan composition is represented by GlyTouCan:G25079LO. Example: UniProtKB:P11717-1, Asn-1312, MOD:00160~GNO:G25079LO." [GlyGen:P11717-1, PMID:29741879, PRO:DNx]
comment: Category=organism-modification. Requested by=GlyGen.
synonym: "hIGF2R/NGlyco:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P11717-1, Asn-1312, MOD:00160~GNO:G25079LO" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P11717 ! cation-independent mannose-6-phosphate receptor (human)
relationship: has_part GNO:G25079LO ! G25079LO
relationship: has_part MOD:00160 ! N4-glycosyl-L-asparagine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000054950
name: cation-independent mannose-6-phosphate receptor N-glycosylated 1 (human)
def: "A cation-independent mannose-6-phosphate receptor (human) that has been N-glycosylated at the residue equivalent to Asn-112 of the amino acid sequence represented by UniProtKB:P11717-1, in which the glycan composition is represented by GlyTouCan:G88374WZ. Example: UniProtKB:P11717-1, Asn-112, MOD:00160~GNO:G88374WZ." [GlyGen:P11717-1, PMID:29671580, PRO:DNx]
comment: Category=organism-modification. Requested by=GlyGen.
synonym: "hIGF2R/NGlyco:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P11717-1, Asn-112, MOD:00160~GNO:G88374WZ" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P11717 ! cation-independent mannose-6-phosphate receptor (human)
relationship: has_part GNO:G88374WZ ! G88374WZ
relationship: has_part MOD:00160 ! N4-glycosyl-L-asparagine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens