[Term] id: PR:P15529-16 name: membrane cofactor protein isoform h3 (human) def: "A membrane cofactor protein (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P15529-16." [PRO:DNx, UniProtKB:P15529] comment: Category=organism-sequence. synonym: "hCD46/iso:h3" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P15529-16 is_a: PR:P15529 ! membrane cofactor protein (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:P15529-14 name: membrane cofactor protein isoform I (human) def: "A membrane cofactor protein (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P15529-14." [PRO:DNx, UniProtKB:P15529] comment: Category=organism-sequence. synonym: "hCD46/iso:I" EXACT PRO-short-label [PRO:DNx] synonym: "membrane cofactor protein isoform del 7-9 (human)" EXACT [UniProtKB:P15529] xref: UniProtKB:P15529-14 is_a: PR:P15529 ! membrane cofactor protein (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:P15529-15 name: membrane cofactor protein isoform K (human) def: "A membrane cofactor protein (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P15529-15." [PRO:DNx, UniProtKB:P15529] comment: Category=organism-sequence. synonym: "hCD46/iso:K" EXACT PRO-short-label [PRO:DNx] synonym: "membrane cofactor protein isoform del 7-8-9 (human)" EXACT [UniProtKB:P15529] xref: UniProtKB:P15529-15 is_a: PR:P15529 ! membrane cofactor protein (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:P15529-12 name: membrane cofactor protein isoform E (human) def: "A membrane cofactor protein (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P15529-12." [PRO:DNx, UniProtKB:P15529] comment: Category=organism-sequence. synonym: "hCD46/iso:E" EXACT PRO-short-label [PRO:DNx] synonym: "membrane cofactor protein isoform C1 (human)" EXACT [UniProtKB:P15529] synonym: "membrane cofactor protein isoform del 7-8 (human)" EXACT [UniProtKB:P15529] xref: UniProtKB:P15529-12 is_a: PR:P15529 ! membrane cofactor protein (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000046642 name: membrane cofactor protein, signal peptide removed form (human) def: "A membrane cofactor protein (human) that has had the signal peptide removed. UniProtKB:P15529, 35-392." [PRO:DNx, Reactome:R-HSA-977362] comment: Category=organism-modification. synonym: "hCD46/SigPep-" EXACT PRO-short-label [PRO:DNx] synonym: "PRO_0000006008" EXACT PRO-proteoform-ftid [PRO:DNx] synonym: "UniProtKB:P15529, 35-392" EXACT PRO-proteoform-std [PRO:DNx] xref: Reactome:R-HSA-977362 "PR:000046642 located_in GO:0005886" intersection_of: PR:P15529 ! membrane cofactor protein (human) intersection_of: lacks_part SO:0000418 ! signal_peptide relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:P15529-10 name: membrane cofactor protein isoform h2 (human) def: "A membrane cofactor protein (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P15529-10." [PRO:DNx, UniProtKB:P15529] comment: Category=organism-sequence. synonym: "hCD46/iso:h2" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P15529-10 is_a: PR:P15529 ! membrane cofactor protein (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:P15529-11 name: membrane cofactor protein isoform C (human) def: "A membrane cofactor protein (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P15529-11." [PRO:DNx, UniProtKB:P15529] comment: Category=organism-sequence. synonym: "hCD46/iso:C" EXACT PRO-short-label [PRO:DNx] synonym: "membrane cofactor protein isoform BC1 (human)" EXACT [UniProtKB:P15529] synonym: "membrane cofactor protein isoform del 7 (human)" EXACT [UniProtKB:P15529] xref: UniProtKB:P15529-11 is_a: PR:P15529 ! membrane cofactor protein (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:P15529-5 name: membrane cofactor protein isoform H (human) def: "A membrane cofactor protein (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P15529-5." [PRO:DNx, UniProtKB:P15529] comment: Category=organism-sequence. synonym: "hCD46/iso:H" EXACT PRO-short-label [PRO:DNx] synonym: "membrane cofactor protein isoform del 9-13 (human)" EXACT [UniProtKB:P15529] xref: UniProtKB:P15529-5 is_a: PR:P15529 ! membrane cofactor protein (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:P15529-4 name: membrane cofactor protein isoform F (human) def: "A membrane cofactor protein (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P15529-4." [PRO:DNx, UniProtKB:P15529] comment: Category=organism-sequence. synonym: "hCD46/iso:F" EXACT PRO-short-label [PRO:DNx] synonym: "membrane cofactor protein isoform C2 (human)" EXACT [UniProtKB:P15529] synonym: "membrane cofactor protein isoform del 7-8-13 (human)" EXACT [UniProtKB:P15529] xref: UniProtKB:P15529-4 is_a: PR:P15529 ! membrane cofactor protein (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:P15529 name: membrane cofactor protein (human) def: "A membrane cofactor protein that is encoded in the genome of human." [PRO:JAN, UniProtKB:P15529] comment: Category=organism-gene. synonym: "MCP" RELATED Gene-based [UniProtKB:P15529] synonym: "CD46" RELATED Gene-based [UniProtKB:P15529] synonym: "MIC10" RELATED Gene-based [UniProtKB:P15529] synonym: "hCD46" EXACT PRO-short-label [PRO:DNx] synonym: "TLX (human)" EXACT [UniProtKB:P15529] synonym: "trophoblast leukocyte common antigen (human)" EXACT [UniProtKB:P15529] xref: UniProtKB:P15529 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000001401 ! membrane cofactor protein relationship: has_gene_template HGNC:6953 ! CD46 (human) [Term] id: PR:P15529-6 name: membrane cofactor protein isoform J (human) def: "A membrane cofactor protein (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P15529-6." [PRO:DNx, UniProtKB:P15529] comment: Category=organism-sequence. synonym: "hCD46/iso:J" EXACT PRO-short-label [PRO:DNx] synonym: "membrane cofactor protein isoform del 7-9-13 (human)" EXACT [UniProtKB:P15529] xref: UniProtKB:P15529-6 is_a: PR:P15529 ! membrane cofactor protein (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:P15529-7 name: membrane cofactor protein isoform L (human) def: "A membrane cofactor protein (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P15529-7." [PRO:DNx, UniProtKB:P15529] comment: Category=organism-sequence. synonym: "hCD46/iso:L" EXACT PRO-short-label [PRO:DNx] synonym: "membrane cofactor protein isoform del 7-8-9-13 (human)" EXACT [UniProtKB:P15529] xref: UniProtKB:P15529-7 is_a: PR:P15529 ! membrane cofactor protein (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:P15529-1 name: membrane cofactor protein isoform A (human) def: "A membrane cofactor protein (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P15529-1." [PRO:DNx, UniProtKB:P15529] comment: Category=organism-sequence. synonym: "hCD46/iso:A" EXACT PRO-short-label [PRO:DNx] synonym: "membrane cofactor protein isoform ABC1 (human)" EXACT [UniProtKB:P15529] synonym: "membrane cofactor protein isoform no del (human)" EXACT [UniProtKB:P15529] xref: UniProtKB:P15529-1 is_a: PR:P15529 ! membrane cofactor protein (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000001401 name: membrane cofactor protein def: "A protein that is a translation product of the human CD46 gene or a 1:1 ortholog thereof. This protein act as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue." [PRO:JAN, UniProtKB:P15529] comment: Category=gene. synonym: "MCP" RELATED Gene-based [] synonym: "TLX" EXACT [] synonym: "CD46" EXACT PRO-short-label [PRO:DNx] synonym: "MIC10" RELATED Gene-based [] synonym: "trophoblast leukocyte common antigen" EXACT [] xref: PIRSF:PIRSF037971 is_a: PR:000000001 ! protein [Term] id: PR:P15529-3 name: membrane cofactor protein isoform D (human) def: "A membrane cofactor protein (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P15529-3." [PRO:DNx, UniProtKB:P15529] comment: Category=organism-sequence. synonym: "hCD46/iso:D" EXACT PRO-short-label [PRO:DNx] synonym: "membrane cofactor protein isoform BC2 (human)" EXACT [UniProtKB:P15529] synonym: "membrane cofactor protein isoform del 7-13 (human)" EXACT [UniProtKB:P15529] xref: UniProtKB:P15529-3 is_a: PR:P15529 ! membrane cofactor protein (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:P15529-8 name: membrane cofactor protein isoform M (human) def: "A membrane cofactor protein (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P15529-8." [PRO:DNx, UniProtKB:P15529] comment: Category=organism-sequence. synonym: "hCD46/iso:M" EXACT PRO-short-label [PRO:DNx] synonym: "membrane cofactor protein isoform del 7-12a-13 (human)" EXACT [UniProtKB:P15529] xref: UniProtKB:P15529-8 is_a: PR:P15529 ! membrane cofactor protein (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:P15529-2 name: membrane cofactor protein isoform B (human) def: "A membrane cofactor protein (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P15529-2." [PRO:DNx, UniProtKB:P15529] comment: Category=organism-sequence. synonym: "hCD46/iso:B" EXACT PRO-short-label [PRO:DNx] synonym: "membrane cofactor protein isoform ABC2 (human)" EXACT [UniProtKB:P15529] synonym: "membrane cofactor protein isoform del 13 (human)" EXACT [UniProtKB:P15529] xref: UniProtKB:P15529-2 is_a: PR:P15529 ! membrane cofactor protein (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:P15529-9 name: membrane cofactor protein isoform N (human) def: "A membrane cofactor protein (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P15529-9." [PRO:DNx, UniProtKB:P15529] comment: Category=organism-sequence. synonym: "hCD46/iso:N" EXACT PRO-short-label [PRO:DNx] synonym: "membrane cofactor protein isoform del 7-8-12-13 (human)" EXACT [UniProtKB:P15529] xref: UniProtKB:P15529-9 is_a: PR:P15529 ! membrane cofactor protein (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:P15529-13 name: membrane cofactor protein isoform G (human) def: "A membrane cofactor protein (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P15529-13." [PRO:DNx, UniProtKB:P15529] comment: Category=organism-sequence. synonym: "hCD46/iso:G" EXACT PRO-short-label [PRO:DNx] synonym: "membrane cofactor protein isoform del 9 (human)" EXACT [UniProtKB:P15529] xref: UniProtKB:P15529-13 is_a: PR:P15529 ! membrane cofactor protein (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens