[Term] id: PR:000047351 name: proteinase-activated receptor 4, signal peptide removed form (human) def: "A proteinase-activated receptor 4 (human) that has had the signal peptide removed. UniProtKB:Q96RI0, 18-385." [PRO:DNx, Reactome:R-HSA-61315] comment: Category=organism-modification. synonym: "hF2RL3/SigPep-" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:Q96RI0, 18-385" EXACT PRO-proteoform-std [PRO:DNx] xref: Reactome:R-HSA-61315 "PR:000047351 located_in GO:0005886" intersection_of: PR:Q96RI0 ! proteinase-activated receptor 4 (human) intersection_of: lacks_part SO:0000418 ! signal_peptide relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:Q96RI0 name: proteinase-activated receptor 4 (human) def: "A proteinase-activated receptor 4 that is encoded in the genome of human." [PRO:WCB, UniProtKB:Q96RI0] comment: Category=organism-gene. synonym: "PAR4" RELATED Gene-based [UniProtKB:Q96RI0] synonym: "F2RL3" RELATED Gene-based [UniProtKB:Q96RI0] synonym: "hF2RL3" EXACT PRO-short-label [PRO:DNx] synonym: "PAR-4 (human)" EXACT [UniProtKB:Q96RI0] synonym: "thrombin receptor-like 3 (human)" EXACT [UniProtKB:Q96RI0] synonym: "coagulation factor II receptor-like 3 (human)" EXACT [UniProtKB:Q96RI0] xref: DTO:02100740 xref: UniProtKB:Q96RI0 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000001664 ! proteinase-activated receptor 4 relationship: has_gene_template HGNC:3540 ! F2RL3 (human) [Term] id: PR:000001664 name: proteinase-activated receptor 4 def: "A proteinase-activated receptor that is a translation product of the human F2RL3 gene or a 1:1 ortholog thereof. It is activated by thrombin and cathepsin G, which cleave the mature peptide, exposing a new amino end. The six new N-terminal residues act as a tethered ligand that induces activity." [PMID:10702240, PMID:9618465, PRO:WCB] comment: Category=gene. synonym: "PAR4" RELATED Gene-based [] synonym: "F2RL3" EXACT PRO-short-label [PRO:DNx] synonym: "PAR-4" EXACT [] synonym: "thrombin receptor-like 3" EXACT [] synonym: "coagulation factor II receptor-like 3" EXACT [] xref: IUPHARobj:350 is_a: PR:000001550 ! proteinase-activated receptor