[Term]
id: PR:000001740
name: myeloid differentiation primary response protein MyD88
def: "A protein that is a translation product of the human MYD88 gene or a 1:1 ortholog thereof. This protein is an adapter involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response." [PMID:9575168, PRO:CNA]
comment: Category=gene.
synonym: "MYD88" EXACT PRO-short-label [PRO:DNx]
xref: PIRSF:PIRSF037756
is_a: PR:000000001 ! protein

[Term]
id: PR:000001741
name: myeloid differentiation primary response protein MyD88 isoform 1
def: "A myeloid differentiation primary response protein MyD88 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q99836-1 or a 1:1 ortholog thereof." [PRO:CNA]
comment: Category=sequence.
synonym: "MYD88/iso:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000001740 ! myeloid differentiation primary response protein MyD88

[Term]
id: PR:000001742
name: myeloid differentiation primary response protein MyD88 sequence variant L93P (human)
def: "A myeloid differentiation primary response protein MyD88 (human) that has a Pro residue at the position equivalent to Leu-93 of the amino acid sequence represented by UniProtKB:Q99836-1. Example: UniProtKB:Q99836-1, Leu-93, CHEBI:50342." [PMID:18669862, PRO:CNA, PRO:DAN]
comment: Category=organism-sequence. Note: This residue is located within the Death domain. Results in a loss of function.
synonym: "hMYD88/var:L93P" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q99836-1, Leu-93, CHEBI:50342" NARROW PRO-proteoform-std [PRO:DAN]
synonym: "myeloid differentiation primary response protein MyD88 sequence variant 1 (human)" EXACT [PRO:DNx]
xref: Reactome:R-HSA-5602612 "PR:000001742 located_in GO:0005829"
xref: UniProtKB_VAR:VAR_047953
is_a: PR:Q99836 ! myeloid differentiation primary response protein MyD88 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000001743
name: myeloid differentiation primary response protein MyD88 sequence variant R196C (human)
def: "A myeloid differentiation primary response protein MyD88 (human) that has a Cys residue at the position equivalent to Arg-196 of the amino acid sequence represented by UniProtKB:Q99836-1. Example: UniProtKB:Q99836-1, Arg-196, CHEBI:29950." [PMID:18669862, PRO:CNA, PRO:DAN]
comment: Category=organism-sequence. Note: This residue is located within the TIR domain. The indicated mutation results in a loss of function.
synonym: "hMYD88/var:R196C" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q99836-1, Arg-196, CHEBI:29950" NARROW PRO-proteoform-std [PRO:DAN]
synonym: "myeloid differentiation primary response protein MyD88 sequence variant 2 (human)" EXACT [PRO:DNx]
xref: Reactome:R-HSA-5602329 "PR:000001743 located_in GO:0005829"
xref: UniProtKB_VAR:VAR_047954
is_a: PR:Q99836 ! myeloid differentiation primary response protein MyD88 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000024846
name: myeloid differentiation primary response protein MyD88 isoform 2
def: "A myeloid differentiation primary response protein MyD88 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P22366-2 or a 1:1 ortholog thereof." [PMID:11909531, PRO:CNA, PRO:DAN]
comment: Category=sequence.
synonym: "MyD88s" EXACT []
synonym: "MYD88/iso:2" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000001740 ! myeloid differentiation primary response protein MyD88

[Term]
id: PR:P22366-2
name: myeloid differentiation primary response protein MyD88 isoform 2 (mouse)
def: "A myeloid differentiation primary response protein MyD88 isoform 2 that is encoded in the genome of mouse." [PMID:11909531, PRO:CNA]
comment: Category=organism-sequence.
synonym: "mMYD88/iso:2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P22366-2
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000024846 ! myeloid differentiation primary response protein MyD88 isoform 2

[Term]
id: PR:P22366-1
name: myeloid differentiation primary response protein MyD88 isoform 1 (mouse)
def: "A myeloid differentiation primary response protein MyD88 isoform 1 that is encoded in the genome of mouse." [PMID:11909531, PRO:CNA]
comment: Category=organism-sequence.
synonym: "mMYD88/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P22366-1
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000001741 ! myeloid differentiation primary response protein MyD88 isoform 1

[Term]
id: PR:Q99836
name: myeloid differentiation primary response protein MyD88 (human)
def: "A myeloid differentiation primary response protein MyD88 that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-gene.
synonym: "MYD88" RELATED Gene-based [UniProtKB:Q99836]
synonym: "hMYD88" EXACT PRO-short-label [PRO:DNx]
xref: Reactome:R-HSA-193946 "PR:Q99836 located_in GO:0005829"
xref: Reactome:R-HSA-166059 "PR:Q99836 located_in GO:0005829"
xref: Reactome:R-HSA-937017 "PR:Q99836 located_in GO:0005886"
xref: Reactome:R-HSA-975123 "PR:Q99836 located_in GO:0010008"
xref: UniProtKB:Q99836
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000001740 ! myeloid differentiation primary response protein MyD88
relationship: has_gene_template HGNC:7562 ! MYD88 (human)

[Term]
id: PR:Q99836-6
name: myeloid differentiation primary response protein MyD88 isoform h6 (human)
def: "A myeloid differentiation primary response protein MyD88 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q99836-6." [PRO:DNx, UniProtKB:Q99836]
comment: Category=organism-sequence.
synonym: "hMYD88/iso:h6" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q99836-6
is_a: PR:Q99836 ! myeloid differentiation primary response protein MyD88 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q6Y1S1
name: myeloid differentiation primary response protein MyD88 (rat)
def: "A myeloid differentiation primary response protein MyD88 that is encoded in the genome of rat." [OMA:Q6Y1S1, PANTHER:PTHR15079:SF0, PRO:DNx]
comment: Category=organism-gene.
synonym: "Myd88" RELATED Gene-based [UniProtKB:Q6Y1S1]
synonym: "rMYD88" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q6Y1S1
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000001740 ! myeloid differentiation primary response protein MyD88
relationship: has_gene_template RGD:735043 ! Myd88 (rat)

[Term]
id: PR:Q99836-5
name: myeloid differentiation primary response protein MyD88 isoform h5 (human)
def: "A myeloid differentiation primary response protein MyD88 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q99836-5." [PRO:DNx, UniProtKB:Q99836]
comment: Category=organism-sequence.
synonym: "hMYD88/iso:h5" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q99836-5
is_a: PR:Q99836 ! myeloid differentiation primary response protein MyD88 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q99836-2
name: myeloid differentiation primary response protein MyD88 isoform 2 (human)
def: "A myeloid differentiation primary response protein MyD88 isoform 2 that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "hMYD88/iso:2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q99836-2
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000024846 ! myeloid differentiation primary response protein MyD88 isoform 2

[Term]
id: PR:Q99836-3
name: myeloid differentiation primary response protein MyD88 isoform h3 (human)
def: "A myeloid differentiation primary response protein MyD88 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q99836-3." [PRO:DNx, UniProtKB:Q99836]
comment: Category=organism-sequence.
synonym: "hMYD88/iso:h3" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q99836-3
is_a: PR:Q99836 ! myeloid differentiation primary response protein MyD88 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q99836-1
name: myeloid differentiation primary response protein MyD88 isoform 1 (human)
def: "A myeloid differentiation primary response protein MyD88 isoform 1 that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "hMYD88/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q99836-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000001741 ! myeloid differentiation primary response protein MyD88 isoform 1

[Term]
id: PR:Q7K105
name: LD20892p (fruit fly)
def: "A myeloid differentiation primary response protein MyD88 that is encoded in the genome of fruit fly." [PANTHER:PTHR15079:SF0, PRO:DNx]
comment: Category=organism-gene.
synonym: "CG2078" RELATED Gene-based [UniProtKB:Q7K105]
synonym: "fly-MYD88" EXACT PRO-short-label [PRO:DNx]
synonym: "myd88, isoform A (fruit fly)" EXACT [UniProtKB:Q7K105]
synonym: "myd88, isoform B (fruit fly)" EXACT [UniProtKB:Q7K105]
synonym: "myd88, isoform C (fruit fly)" EXACT [UniProtKB:Q7K105]
synonym: "MyD88 adapter protein (fruit fly)" EXACT [UniProtKB:Q7K105]
xref: UniProtKB:Q7K105
intersection_of: only_in_taxon NCBITaxon:7227 ! Drosophila melanogaster
intersection_of: PR:000001740 ! myeloid differentiation primary response protein MyD88
relationship: has_gene_template FlyBase:FBgn0033402 ! Myd88 (fruit fly)

[Term]
id: PR:A5HNF6
name: myeloid differentiation primary response protein MyD88 (chicken)
def: "A myeloid differentiation primary response protein MyD88 that is encoded in the genome of chicken." [OMA:A5HNF6, PMID:18582498, PRO:CNA]
comment: Category=organism-gene. Note: The chicken MyD88 gene was cloned and its expression was detected in cecum, heart, spleen, liver, kidney, female reproductive tract, thymus and bursa. Over-expression of chicken MyD88 significantly stimulated the activation of NF-kB in vitro.
synonym: "MYD88" RELATED Gene-based [UniProtKB:A5HNF6]
synonym: "chick-MYD88" EXACT PRO-short-label [PRO:DNx]
synonym: "RCJMB04_14h3" RELATED Gene-based [UniProtKB:A5HNF6]
xref: Reactome:R-GGA-433900 "PR:A5HNF6 located_in GO:0005886"
xref: Reactome:R-GGA-433987 "PR:A5HNF6 located_in GO:0005829"
xref: Reactome:R-GGA-573258 "PR:A5HNF6 located_in GO:0010008"
xref: UniProtKB:A5HNF6
intersection_of: only_in_taxon NCBITaxon:9031 ! Gallus gallus
intersection_of: PR:000001740 ! myeloid differentiation primary response protein MyD88
relationship: has_gene_template CGNC:4445 ! MYD88 (chicken)

[Term]
id: PR:P22366
name: myeloid differentiation primary response protein MyD88 (mouse)
def: "A myeloid differentiation primary response protein MyD88 that is encoded in the genome of mouse." [OMA:P22366, PRO:CNA]
comment: Category=organism-gene.
synonym: "Myd88" RELATED Gene-based [UniProtKB:P22366]
synonym: "mMYD88" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P22366
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000001740 ! myeloid differentiation primary response protein MyD88
relationship: has_gene_template MGI:108005 ! Myd88 (mouse)

[Term]
id: PR:Q5XJ85
name: myeloid differentiation primary response protein MyD88 (zebrafish)
def: "A myeloid differentiation primary response protein MyD88 that is encoded in the genome of zebrafish." [OMA:Q5XJ85, PRO:DNx]
comment: Category=organism-gene.
synonym: "myd88" RELATED Gene-based [UniProtKB:Q5XJ85]
synonym: "z-MYD88" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q5XJ85
intersection_of: only_in_taxon NCBITaxon:7955 ! Danio rerio
intersection_of: PR:000001740 ! myeloid differentiation primary response protein MyD88
relationship: has_gene_template ZFIN:ZDB-GENE-040219-3 ! myd88 (zebrafish)

[Term]
id: PR:Q99836-4
name: myeloid differentiation primary response protein MyD88 isoform h4 (human)
def: "A myeloid differentiation primary response protein MyD88 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q99836-4." [PRO:DNx, UniProtKB:Q99836]
comment: Category=organism-sequence.
synonym: "hMYD88/iso:h4" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q99836-4
is_a: PR:Q99836 ! myeloid differentiation primary response protein MyD88 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens