[Term]
id: PR:Q04861-1
name: nuclear factor NF-kappa-B p105 subunit isoform 1 (chicken)
def: "A nuclear factor NF-kappa-B p105 subunit (chicken) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q04861-1." [PRO:DNx, UniProtKB:Q04861]
comment: Category=organism-sequence.
synonym: "chick-NFKB1/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q04861-1
is_a: PR:Q04861 ! nuclear factor NF-kappa-B p105 subunit (chicken)
relationship: only_in_taxon NCBITaxon:9031 ! Gallus gallus

[Term]
id: PR:Q04861-2
name: nuclear factor NF-kappa-B p105 subunit isoform 2 (chicken)
def: "A nuclear factor NF-kappa-B p105 subunit (chicken) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q04861-2." [PRO:DNx, UniProtKB:Q04861]
comment: Category=organism-sequence.
synonym: "chick-NFKB1/iso:2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q04861-2
is_a: PR:Q04861 ! nuclear factor NF-kappa-B p105 subunit (chicken)
relationship: only_in_taxon NCBITaxon:9031 ! Gallus gallus

[Term]
id: PR:Q04861-3
name: nuclear factor NF-kappa-B p105 subunit isoform 3 (chicken)
def: "A nuclear factor NF-kappa-B p105 subunit (chicken) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q04861-3." [PRO:DNx, UniProtKB:Q04861]
comment: Category=organism-sequence.
synonym: "chick-NFKB1/iso:3" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q04861-3
is_a: PR:Q04861 ! nuclear factor NF-kappa-B p105 subunit (chicken)
relationship: only_in_taxon NCBITaxon:9031 ! Gallus gallus

[Term]
id: PR:P25799-6
name: nuclear factor NF-kappa-B p105 subunit isoform m6 (mouse)
def: "A nuclear factor NF-kappa-B p105 subunit (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P25799-6." [PRO:DNx, UniProtKB:P25799]
comment: Category=organism-sequence.
synonym: "mNFKB1/iso:m6" EXACT PRO-short-label [PRO:DNx]
synonym: "nuclear factor NF-kappa-B p105 subunit isoform p63 (mouse)" EXACT [UniProtKB:P25799]
synonym: "nuclear factor NF-kappa-B p105 subunit isoform I-kappa-B gamma-1 (mouse)" EXACT [UniProtKB:P25799]
xref: UniProtKB:P25799-6
is_a: PR:P25799 ! nuclear factor NF-kappa-B p105 subunit (mouse)
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:P25799-1
name: nuclear factor NF-kappa-B p105 subunit isoform 1 (mouse)
def: "A nuclear factor NF-kappa-B p105 subunit isoform 1 that is encoded in the genome of mouse." [PRO:JAN]
comment: Category=organism-sequence.
synonym: "mNFKB1/iso:1" EXACT PRO-short-label [PRO:DNx]
synonym: "nuclear factor NF-kappa-B p105 subunit isoform p105 (mouse)" EXACT [UniProtKB:P25799]
xref: UniProtKB:P25799-1
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000001755 ! nuclear factor NF-kappa-B p105 subunit isoform 1

[Term]
id: PR:P25799-2
name: nuclear factor NF-kappa-B p105 subunit isoform m2 (mouse)
def: "A nuclear factor NF-kappa-B p105 subunit (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P25799-2." [PRO:DNx, UniProtKB:P25799]
comment: Category=organism-sequence.
synonym: "mNFKB1/iso:m2" EXACT PRO-short-label [PRO:DNx]
synonym: "nuclear factor NF-kappa-B p105 subunit isoform p84 (mouse)" EXACT [UniProtKB:P25799]
xref: UniProtKB:P25799-2
is_a: PR:P25799 ! nuclear factor NF-kappa-B p105 subunit (mouse)
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:P25799-3
name: nuclear factor NF-kappa-B p105 subunit isoform m3 (mouse)
def: "A nuclear factor NF-kappa-B p105 subunit (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P25799-3." [PRO:DNx, UniProtKB:P25799]
comment: Category=organism-sequence.
synonym: "mNFKB1/iso:m3" EXACT PRO-short-label [PRO:DNx]
synonym: "nuclear factor NF-kappa-B p105 subunit isoform p98 (mouse)" EXACT [UniProtKB:P25799]
xref: UniProtKB:P25799-3
is_a: PR:P25799 ! nuclear factor NF-kappa-B p105 subunit (mouse)
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:P25799-4
name: nuclear factor NF-kappa-B p105 subunit isoform m4 (mouse)
def: "A nuclear factor NF-kappa-B p105 subunit (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P25799-4." [PRO:DNx, UniProtKB:P25799]
comment: Category=organism-sequence.
synonym: "mNFKB1/iso:m4" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P25799-4
is_a: PR:P25799 ! nuclear factor NF-kappa-B p105 subunit (mouse)
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:P25799
name: nuclear factor NF-kappa-B p105 subunit (mouse)
def: "A nuclear factor NF-kappa-B p105 subunit that is encoded in the genome of mouse." [OMA:P25799, PRO:DNx]
comment: Category=organism-gene.
synonym: "Nfkb1" RELATED Gene-based [UniProtKB:P25799]
synonym: "mNFKB1" EXACT PRO-short-label [PRO:DNx]
synonym: "EBP-1 (mouse)" EXACT [UniProtKB:P25799]
synonym: "DNA-binding factor KBF1 (mouse)" EXACT [UniProtKB:P25799]
synonym: "NF-kappa-B1 p84/NF-kappa-B1 p98 (mouse)" EXACT [UniProtKB:P25799]
synonym: "nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (mouse)" EXACT [UniProtKB:P25799]
xref: UniProtKB:P25799
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000001754 ! nuclear factor NF-kappa-B p105 subunit
relationship: has_gene_template MGI:97312 ! Nfkb1 (mouse)

[Term]
id: PR:000018519
name: nuclear factor NF-kappa-B p105 subunit proteolytic cleavage product
def: "A nuclear factor NF-kappa-B p105 subunit that has been processed by proteolytic cleavage." [PRO:DNx]
comment: Category=modification.
synonym: "NFKB1/ClvPrd" EXACT PRO-short-label [PRO:DNx]
intersection_of: output_of GO:0016485 ! protein processing
intersection_of: PR:000001754 ! nuclear factor NF-kappa-B p105 subunit

[Term]
id: PR:P25799-7
name: nuclear factor NF-kappa-B p105 subunit isoform m7 (mouse)
def: "A nuclear factor NF-kappa-B p105 subunit (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P25799-7." [PRO:DNx, UniProtKB:P25799]
comment: Category=organism-sequence.
synonym: "mNFKB1/iso:m7" EXACT PRO-short-label [PRO:DNx]
synonym: "nuclear factor NF-kappa-B p105 subunit isoform p55 (mouse)" EXACT [UniProtKB:P25799]
synonym: "nuclear factor NF-kappa-B p105 subunit isoform I-kappa-B gamma-2 (mouse)" EXACT [UniProtKB:P25799]
xref: UniProtKB:P25799-7
is_a: PR:P25799 ! nuclear factor NF-kappa-B p105 subunit (mouse)
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:P19838-3
name: nuclear factor NF-kappa-B p105 subunit isoform h3 (human)
def: "A nuclear factor NF-kappa-B p105 subunit (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P19838-3." [PRO:DNx, UniProtKB:P19838]
comment: Category=organism-sequence.
synonym: "hNFKB1/iso:h3" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P19838-3
is_a: PR:P19838 ! nuclear factor NF-kappa-B p105 subunit (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P19838-2
name: nuclear factor NF-kappa-B p105 subunit isoform 2 (human)
def: "A nuclear factor NF-kappa-B p105 subunit isoform 3 that is encoded in the genome of human." [PRO:JAN]
comment: Category=organism-sequence.
synonym: "hNFKB1/iso:2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P19838-2
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000001761 ! nuclear factor NF-kappa-B p105 subunit isoform 3

[Term]
id: PR:P19838-1
name: nuclear factor NF-kappa-B p105 subunit isoform 1 (human)
def: "A nuclear factor NF-kappa-B p105 subunit isoform 2 that is encoded in the genome of human." [PRO:DNx, UniProtKB:P19838]
comment: Category=organism-sequence.
synonym: "hNFKB1/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P19838-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000001758 ! nuclear factor NF-kappa-B p105 subunit isoform 2

[Term]
id: PR:Q04861
name: nuclear factor NF-kappa-B p105 subunit (chicken)
def: "A nuclear factor NF-kappa-B p105 subunit that is encoded in the genome of chicken." [OMA:Q04861, PANTHER:PTHR24169:SF4, PRO:DNx]
comment: Category=organism-gene.
synonym: "NFKB1" RELATED Gene-based [UniProtKB:Q04861]
synonym: "chick-NFKB1" EXACT PRO-short-label [PRO:DNx]
synonym: "nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (chicken)" EXACT [UniProtKB:Q04861]
xref: UniProtKB:Q04861
intersection_of: only_in_taxon NCBITaxon:9031 ! Gallus gallus
intersection_of: PR:000001754 ! nuclear factor NF-kappa-B p105 subunit
relationship: has_gene_template NCBIGene:396033 ! NFKB1 (chicken)

[Term]
id: PR:000035834
name: nuclear factor NF-kappa-B p50 subunit (human)
def: "A nuclear factor NF-kappa-B p50 subunit in human. Example: UniProtKB:P19838-1, 1-433." [PRO:DNx, UniProtKB:P19838]
comment: Category=organism-modification.
synonym: "hNFKBp50" EXACT PRO-short-label [PRO:DAN]
synonym: "p50 (human)" BROAD [PRO:DNx]
synonym: "PRO_0000030311" NARROW PRO-proteoform-ftid [PRO:DNx]
synonym: "NFKB1 p50 (human)" EXACT []
synonym: "NF-KAPPA-B P50 (human)" EXACT []
synonym: "UniProtKB:P19838-1, 1-433" NARROW PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-168168 "PR:000035834 located_in GO:0005829"
xref: Reactome:R-HSA-177655 "PR:000035834 located_in GO:0005654"
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000001757 ! nuclear factor NF-kappa-B p50 subunit

[Term]
id: PR:P25799-5
name: nuclear factor NF-kappa-B p105 subunit isoform m5 (mouse)
def: "A nuclear factor NF-kappa-B p105 subunit (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P25799-5." [PRO:DNx, UniProtKB:P25799]
comment: Category=organism-sequence.
synonym: "mNFKB1/iso:m5" EXACT PRO-short-label [PRO:DNx]
synonym: "nuclear factor NF-kappa-B p105 subunit isoform P70 (mouse)" EXACT [UniProtKB:P25799]
synonym: "nuclear factor NF-kappa-B p105 subunit isoform I-kappa-B gamma (mouse)" EXACT [UniProtKB:P25799]
xref: UniProtKB:P25799-5
is_a: PR:P25799 ! nuclear factor NF-kappa-B p105 subunit (mouse)
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:Q94527
name: nuclear factor NF-kappa-B p110 subunit (fruit fly)
def: "A nuclear factor NF-kappa-B p105 subunit that is encoded in the genome of fruit fly." [OMA:Q94527, PRO:DNx]
comment: Category=organism-gene.
synonym: "Rel" RELATED Gene-based [UniProtKB:Q94527]
synonym: "CG11992" RELATED Gene-based [UniProtKB:Q94527]
synonym: "fly-NFKB1" EXACT PRO-short-label [PRO:DNx]
synonym: "Rel-p110 (fruit fly)" EXACT [UniProtKB:Q94527]
synonym: "relish protein (fruit fly)" EXACT [UniProtKB:Q94527]
xref: UniProtKB:Q94527
intersection_of: only_in_taxon NCBITaxon:7227 ! Drosophila melanogaster
intersection_of: PR:000001754 ! nuclear factor NF-kappa-B p105 subunit
relationship: has_gene_template FlyBase:FBgn0014018 ! Rel (fruit fly)

[Term]
id: PR:000045706
name: nuclear factor NF-kappa-B p105 subunit phosphorylated 1 (human)
def: "A nuclear factor NF-kappa-B p105 subunit (human) that has been phosphorylated on the residue at the position equivalent to Ser-927 of the amino acid sequence represented by UniProtKB:P19838-1. Example: UniProtKB:P19838-1, Ser-927, MOD:00046." [PMID:11297557, PMID:11976329, iPTMnet:P19838]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:11297557, PMID:11976329). Status=unreviewed.
synonym: "hNFKB1/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P19838-1, Ser-927, MOD:00046" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P19838 ! nuclear factor NF-kappa-B p105 subunit (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q94527-1
name: nuclear factor NF-kappa-B p110 subunit isoform Major (fruit fly)
def: "A nuclear factor NF-kappa-B p110 subunit (fruit fly) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q94527-1." [PRO:DNx, UniProtKB:Q94527]
comment: Category=organism-sequence.
synonym: "fly-NFKB1/iso:Major" EXACT PRO-short-label [PRO:DNx]
synonym: "nuclear factor NF-kappa-B p110 subunit isoform A (fruit fly)" EXACT [UniProtKB:Q94527]
synonym: "nuclear factor NF-kappa-B p110 subunit isoform B (fruit fly)" EXACT [UniProtKB:Q94527]
synonym: "nuclear factor NF-kappa-B p110 subunit isoform C (fruit fly)" EXACT [UniProtKB:Q94527]
synonym: "nuclear factor NF-kappa-B p110 subunit isoform p110 (fruit fly)" EXACT [UniProtKB:Q94527]
xref: UniProtKB:Q94527-1
is_a: PR:Q94527 ! nuclear factor NF-kappa-B p110 subunit (fruit fly)
relationship: only_in_taxon NCBITaxon:7227 ! Drosophila melanogaster

[Term]
id: PR:000001757
name: nuclear factor NF-kappa-B p50 subunit
def: "A nuclear factor NF-kappa-B p105 subunit isoform 1 that has been processed by proteolytic cleavage to remove the C-terminal domain of p105 downstream from the 23 residue, glycine rich region (GRR). GRR functions as a processing signal for the generation of p50." [PMID:2203532, PMID:8628291, PRO:JAN]
comment: Category=modification.
synonym: "p50" BROAD [PRO:DNx]
synonym: "NFKBp50" EXACT PRO-short-label [PRO:DAN]
synonym: "NFKB1 p50" EXACT []
synonym: "NF-KAPPA-B P50" EXACT []
synonym: "nuclear factor NF-kappa-B p105 subunit isoform 1 cleaved 1" EXACT []
is_a: PR:000001755 ! nuclear factor NF-kappa-B p105 subunit isoform 1
relationship: output_of GO:0016485 ! protein processing

[Term]
id: PR:000001755
name: nuclear factor NF-kappa-B p105 subunit isoform 1
def: "A nuclear factor NF-kappa-B p105 subunit that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P25799-1 or a 1:1 ortholog thereof." [PRO:JAN]
comment: Category=sequence.
synonym: "NFKB1/iso:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000001754 ! nuclear factor NF-kappa-B p105 subunit

[Term]
id: PR:000001754
name: nuclear factor NF-kappa-B p105 subunit
def: "A transcription factor NF-kappa-B subunit that is a translation product of the human NFKB1 gene or a 1:1 ortholog thereof. NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis." [PMID:15485931, PRO:JAN]
comment: Category=gene.
synonym: "EBP-1" EXACT []
synonym: "NFKB1" EXACT PRO-short-label [PRO:DNx]
synonym: "DNA-binding factor KBF1" EXACT []
synonym: "NF-kappa-B1 p84/NF-kappa-B1 p98" EXACT []
synonym: "nuclear factor of kappa light polypeptide gene enhancer in B-cells 1" EXACT []
is_a: PR:000001753 ! transcription factor NF-kappa-B subunit

[Term]
id: PR:Q94527-2
name: nuclear factor NF-kappa-B p110 subunit isoform Maternal (fruit fly)
def: "A nuclear factor NF-kappa-B p110 subunit (fruit fly) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q94527-2." [PRO:DNx, UniProtKB:Q94527]
comment: Category=organism-sequence.
synonym: "fly-NFKB1/iso:Maternal" EXACT PRO-short-label [PRO:DNx]
synonym: "nuclear factor NF-kappa-B p110 subunit isoform D (fruit fly)" EXACT [UniProtKB:Q94527]
synonym: "nuclear factor NF-kappa-B p110 subunit isoform p100 (fruit fly)" EXACT [UniProtKB:Q94527]
xref: UniProtKB:Q94527-2
is_a: PR:Q94527 ! nuclear factor NF-kappa-B p110 subunit (fruit fly)
relationship: only_in_taxon NCBITaxon:7227 ! Drosophila melanogaster

[Term]
id: PR:000001759
name: nuclear factor NF-kappa-B p105 subunit isoform 2 phosphorylated form
def: "A nuclear factor NF-kappa-B p105 subunit isoform 2 that includes at least one phosphorylated residue." [PRO:JAN]
comment: Category=modification.
synonym: "NFKB1/iso:2/PhosRes+" EXACT PRO-short-label [PRO:DNx]
intersection_of: has_part MOD:00696 ! phosphorylated residue
intersection_of: PR:000001758 ! nuclear factor NF-kappa-B p105 subunit isoform 2

[Term]
id: PR:000001758
name: nuclear factor NF-kappa-B p105 subunit isoform 2
def: "A nuclear factor NF-kappa-B p105 subunit that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P19838-1 or a 1:1 ortholog thereof." [PMID:1992489]
comment: Category=sequence.
synonym: "NFKB1/iso:2" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000001754 ! nuclear factor NF-kappa-B p105 subunit

[Term]
id: PR:000048595
name: nuclear factor NF-kappa-B p105 subunit phosphorylated 2 (human)
def: "A nuclear factor NF-kappa-B p105 subunit (human) that has been post-translationally modified to include phosphoserine at positions 927 and 932 of the amino acid sequence represented by UniProtKB:P19838. UniProtKB:P19838, Ser-927/Ser-932, MOD:00046." [PRO:DNx, Reactome:R-HSA-451611]
comment: Category=organism-modification.
synonym: "hNFKB1/Phos:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P19838, Ser-927/Ser-932, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-451611 "PR:000048595 located_in GO:0005829"
is_a: PR:P19838 ! nuclear factor NF-kappa-B p105 subunit (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000028540
name: nuclear factor NF-kappa-B p50 subunit (mouse)
def: "A nuclear factor NF-kappa-B p50 subunit in mouse. Example: UniProtKB:P25799-1, 1-431." [PMID:2203532, PRO:CNA]
comment: Category=organism-modification.
synonym: "mNFKBp50" EXACT PRO-short-label [PRO:DAN]
synonym: "p50 (mouse)" BROAD [PRO:DNx]
synonym: "PRO_0000030313" NARROW PRO-proteoform-ftid [PRO:DNx]
synonym: "NFKB1 p50 (mouse)" EXACT []
synonym: "NF-KAPPA-B P50 (mouse)" EXACT []
synonym: "UniProtKB:P25799-1, 1-431" NARROW PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000001757 ! nuclear factor NF-kappa-B p50 subunit

[Term]
id: PR:000001760
name: nuclear factor NF-kappa-B p105 subunit isoform 2 phosphorylated 1
def: "A nuclear factor NF-kappa-B p105 subunit isoform 2 phosphorylated form in which the phosphorylation occurs by the action of GSK-3 beta which forms an in vivo complex with and specifically phosphorylates nuclear factor NF-kappa-B p105 subunit at two Ser residues in the C-terminal region contiguos to the Death domain. Phosphorylation by GSK-3 stabilizes the protein. Example: UniProtKB:P19838-1, Ser-903/Ser-907, MOD:00046." [PMID:12871932, PRO:JAN]
comment: Category=modification.
synonym: "NFKB1/iso:2/Phos:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000001759 ! nuclear factor NF-kappa-B p105 subunit isoform 2 phosphorylated form
relationship: has_part MOD:00046 ! O-phospho-L-serine

[Term]
id: PR:000001762
name: nuclear factor NF-kappa-B p105 subunit isoform 2 phosphorylated 2
def: "A nuclear factor NF-kappa-B p105 subunit isoform 2 phosphorylated form that has been pre-phosphorylated by GSK-3 beta (PR:000001760) followed by phosphorylation of the two Ser residues within the conserved motif DSGVETS in the PEST region. Phosphorylation occurs after the stimulation of cells with proinflammatory cytokines, such as tumor necrosis factor or interleukin-1. This phosphorylation results in accelerated nuclear factor NF-kappa-B p105 degradation. Example: UniProtKB:P19838-1, Ser-903/Ser-907/Ser-927/Ser-932, MOD:00046." [PMID:12482991, PMID:12871932]
comment: Category=modification.
synonym: "NFKB1/iso:2/Phos:2" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000001759 ! nuclear factor NF-kappa-B p105 subunit isoform 2 phosphorylated form
relationship: has_part MOD:00046 ! O-phospho-L-serine

[Term]
id: PR:P19838
name: nuclear factor NF-kappa-B p105 subunit (human)
def: "A nuclear factor NF-kappa-B p105 subunit that is encoded in the genome of human." [PRO:DNx]
comment: Category=organism-gene.
synonym: "NFKB1" RELATED Gene-based [UniProtKB:P19838]
synonym: "hNFKB1" EXACT PRO-short-label [PRO:DNx]
synonym: "EBP-1 (human)" EXACT [UniProtKB:P19838]
synonym: "DNA-binding factor KBF1 (human)" EXACT [UniProtKB:P19838]
synonym: "nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (human)" EXACT [UniProtKB:P19838]
xref: Reactome:R-HSA-451607 "PR:P19838 located_in GO:0005829"
xref: Reactome:R-HSA-6806304 "PR:P19838 located_in GO:0005576"
xref: Reactome:R-HSA-6799557 "PR:P19838 located_in GO:0035580"
xref: Reactome:R-HSA-6801004 "PR:P19838 located_in GO:0034774"
xref: UniProtKB:P19838
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000001754 ! nuclear factor NF-kappa-B p105 subunit
relationship: has_gene_template HGNC:7794 ! NFKB1 (human)

[Term]
id: PR:000001761
name: nuclear factor NF-kappa-B p105 subunit isoform 3
def: "A nuclear factor NF-kappa-B p105 subunit that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P19838-2 or a 1:1 ortholog thereof." [PRO:JAN]
comment: Category=sequence.
synonym: "NFKB1/iso:3" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000001754 ! nuclear factor NF-kappa-B p105 subunit