[Term]
id: PR:Q60680-3
name: inhibitor of nuclear factor kappa-B kinase subunit alpha isoform m3 (mouse)
def: "An inhibitor of nuclear factor kappa-B kinase subunit alpha (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q60680-3." [PRO:DNx, UniProtKB:Q60680]
comment: Category=organism-sequence.
synonym: "mCHUK/iso:m3" EXACT PRO-short-label [PRO:DNx]
synonym: "inhibitor of nuclear factor kappa-B kinase subunit alpha isoform Delta H (mouse)" EXACT [UniProtKB:Q60680]
xref: UniProtKB:Q60680-3
is_a: PR:Q60680 ! inhibitor of nuclear factor kappa-B kinase subunit alpha (mouse)
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:000045576
name: inhibitor of nuclear factor kappa-B kinase subunit alpha phosphorylated 2 (human)
def: "An inhibitor of nuclear factor kappa-B kinase subunit alpha (human) that has been phosphorylated at Thr-23. UniProtKB:O15111, Thr-23, MOD:00047." [PMID:10485710, Reactome:R-HSA-177667, Reactome:R-HSA-198615, iPTMnet:O15111]
comment: Category=organism-modification.
synonym: "hCHUK/Phos:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:O15111, Thr-23, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-198615 "PR:000045576 located_in GO:0005829"
is_a: PR:O15111 ! inhibitor of nuclear factor kappa-B kinase subunit alpha (human)
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q60680-1
name: inhibitor of nuclear factor kappa-B kinase subunit alpha isoform 1 (mouse)
def: "An inhibitor of nuclear factor kappa-B kinase subunit alpha isoform 1 that is encoded in the genome of mouse." [PRO:CNx]
comment: Category=organism-sequence.
synonym: "mCHUK/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q60680-1
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000026820 ! inhibitor of nuclear factor kappa-B kinase subunit alpha isoform 1

[Term]
id: PR:Q60680-2
name: inhibitor of nuclear factor kappa-B kinase subunit alpha isoform m2 (mouse)
def: "An inhibitor of nuclear factor kappa-B kinase subunit alpha (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q60680-2." [PRO:DNx, UniProtKB:Q60680]
comment: Category=organism-sequence.
synonym: "mCHUK/iso:m2" EXACT PRO-short-label [PRO:DNx]
synonym: "inhibitor of nuclear factor kappa-B kinase subunit alpha isoform Delta LH (mouse)" EXACT [UniProtKB:Q60680]
xref: UniProtKB:Q60680-2
is_a: PR:Q60680 ! inhibitor of nuclear factor kappa-B kinase subunit alpha (mouse)
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:O15111
name: inhibitor of nuclear factor kappa-B kinase subunit alpha (human)
def: "An inhibitor of nuclear factor kappa-B kinase subunit alpha that is encoded in the genome of human." [PRO:DNx, UniProtKB:O15111]
comment: Category=organism-gene.
synonym: "CHUK" RELATED Gene-based [UniProtKB:O15111]
synonym: "IKKA" RELATED Gene-based [UniProtKB:O15111]
synonym: "TCF16" RELATED Gene-based [UniProtKB:O15111]
synonym: "hCHUK" EXACT PRO-short-label [PRO:DNx]
synonym: "IKK1 (human)" EXACT [UniProtKB:O15111]
synonym: "IKK-A (human)" EXACT [UniProtKB:O15111]
synonym: "IkBKA (human)" EXACT [UniProtKB:O15111]
synonym: "TCF-16 (human)" EXACT [UniProtKB:O15111]
synonym: "NFKBIKA (human)" EXACT [UniProtKB:O15111]
synonym: "IKK-alpha (human)" EXACT [UniProtKB:O15111]
synonym: "IkappaB kinase (human)" EXACT [UniProtKB:O15111]
synonym: "I-kappa-B kinase 1 (human)" EXACT [UniProtKB:O15111]
synonym: "I-kappa-B kinase alpha (human)" EXACT [UniProtKB:O15111]
synonym: "transcription factor 16 (human)" EXACT [UniProtKB:O15111]
synonym: "conserved helix-loop-helix ubiquitous kinase (human)" EXACT [UniProtKB:O15111]
synonym: "nuclear factor NF-kappa-B inhibitor kinase alpha (human)" EXACT [UniProtKB:O15111]
xref: Reactome:R-HSA-168104 "PR:O15111 located_in GO:0005829"
xref: Reactome:R-HSA-1168562 "PR:O15111 located_in GO:0005886"
xref: DTO:03100181
xref: UniProtKB:O15111
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000001775 ! inhibitor of nuclear factor kappa-B kinase subunit alpha
relationship: has_gene_template HGNC:1974 ! CHUK (human)

[Term]
id: PR:Q4G3H4
name: inhibitor of nuclear factor kappa-B kinase subunit alpha (zebrafish)
def: "An inhibitor of nuclear factor kappa-B kinase subunit alpha that is encoded in the genome of zebrafish." [PANTHER:PTHR22969:SF8, PRO:DNx]
comment: Category=organism-gene.
synonym: "chuk" RELATED Gene-based [UniProtKB:Q4G3H4]
synonym: "ikk1" RELATED Gene-based [UniProtKB:Q4G3H4]
synonym: "z-CHUK" EXACT PRO-short-label [PRO:DNx]
synonym: "zgc:56539" RELATED Gene-based [UniProtKB:Q4G3H4]
synonym: "IKK1 (zebrafish)" EXACT [UniProtKB:Q4G3H4]
synonym: "IKK-A (zebrafish)" EXACT [UniProtKB:Q4G3H4]
synonym: "IkBKA (zebrafish)" EXACT [UniProtKB:Q4G3H4]
synonym: "NFKBIKA (zebrafish)" EXACT [UniProtKB:Q4G3H4]
synonym: "IKK-alpha (zebrafish)" EXACT [UniProtKB:Q4G3H4]
synonym: "IkappaB kinase (zebrafish)" EXACT [UniProtKB:Q4G3H4]
synonym: "I-kappa-B kinase 1 (zebrafish)" EXACT [UniProtKB:Q4G3H4]
synonym: "I kappa-B kinase alpha (zebrafish)" EXACT [UniProtKB:Q4G3H4]
synonym: "conserved helix-loop-helix ubiquitous kinase (zebrafish)" EXACT [UniProtKB:Q4G3H4]
synonym: "nuclear factor NF-kappa-B inhibitor kinase alpha (zebrafish)" EXACT [UniProtKB:Q4G3H4]
xref: UniProtKB:Q4G3H4
intersection_of: only_in_taxon NCBITaxon:7955 ! Danio rerio
intersection_of: PR:000001775 ! inhibitor of nuclear factor kappa-B kinase subunit alpha
relationship: has_gene_template ZFIN:ZDB-GENE-040426-1069 ! chuk (zebrafish)

[Term]
id: PR:Q5ZJB4
name: inhibitor of nuclear factor kappa-B kinase subunit alpha (chicken)
def: "An inhibitor of nuclear factor kappa-B kinase subunit alpha that is encoded in the genome of chicken." [PANTHER:PTHR22969:SF8, PRO:DNx]
comment: Category=organism-gene.
synonym: "CHUK" RELATED Gene-based [UniProtKB:Q5ZJB4]
synonym: "IKKA" RELATED Gene-based [UniProtKB:Q5ZJB4]
synonym: "chick-CHUK" EXACT PRO-short-label [PRO:DNx]
synonym: "RCJMB04_19h23" RELATED Gene-based [UniProtKB:Q5ZJB4]
synonym: "IKK-A (chicken)" EXACT [UniProtKB:Q5ZJB4]
synonym: "IkBKA (chicken)" EXACT [UniProtKB:Q5ZJB4]
synonym: "NFKBIKA (chicken)" EXACT [UniProtKB:Q5ZJB4]
synonym: "IKK-alpha (chicken)" EXACT [UniProtKB:Q5ZJB4]
synonym: "IkappaB kinase (chicken)" EXACT [UniProtKB:Q5ZJB4]
synonym: "I kappa-B kinase alpha (chicken)" EXACT [UniProtKB:Q5ZJB4]
synonym: "conserved helix-loop-helix ubiquitous kinase (chicken)" EXACT [UniProtKB:Q5ZJB4]
synonym: "nuclear factor NF-kappa-B inhibitor kinase alpha (chicken)" EXACT [UniProtKB:Q5ZJB4]
xref: UniProtKB:Q5ZJB4
intersection_of: only_in_taxon NCBITaxon:9031 ! Gallus gallus
intersection_of: PR:000001775 ! inhibitor of nuclear factor kappa-B kinase subunit alpha
relationship: has_gene_template NCBIGene:423669 ! CHUK (chicken)

[Term]
id: PR:000036121
name: inhibitor of nuclear factor kappa-B kinase subunit alpha isoform 1 phosphorylated 1 (mouse)
def: "An inhibitor of nuclear factor kappa-B kinase subunit alpha isoform 1 phosphorylated 1 in mouse. UniProtKB:Q60680-1, Ser-176/Ser-180, MOD:00046." [PMID:16751795, PRO:CNA]
comment: Category=organism-modification. Requested by=TLR.
synonym: "mCHUK/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "phospho-IKK1 (mouse)" EXACT []
synonym: "UniProtKB:Q60680-1, Ser-176/Ser-180, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000026822 ! inhibitor of nuclear factor kappa-B kinase subunit alpha isoform 1 phosphorylated 1
relationship: has_part MOD:00046 ! O-phospho-L-serine

[Term]
id: PR:000026822
name: inhibitor of nuclear factor kappa-B kinase subunit alpha isoform 1 phosphorylated 1
def: "An inhibitor of nuclear factor kappa-B kinase subunit alpha isoform 1 that has been phosphorylated in the two Ser residues within the activation loop. Example: UniProtKB:O15111-1, Ser-176/Ser-180, MOD:00046." [PRO:CNx]
comment: Category=modification.
synonym: "CHUK/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000026820 ! inhibitor of nuclear factor kappa-B kinase subunit alpha isoform 1
relationship: has_part MOD:00046 ! O-phospho-L-serine

[Term]
id: PR:000026823
name: inhibitor of nuclear factor kappa-B kinase subunit alpha isoform 1 phosphorylated 1 (human)
def: "An inhibitor of nuclear factor kappa-B kinase subunit alpha isoform 1 phosphorylated 1 in human. UniProtKB:O15111-1, Ser-176/Ser-180, MOD:00046." [PRO:CNx]
comment: Category=organism-modification.
synonym: "phospho-IKK1" EXACT []
synonym: "hCHUK/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:O15111-1, Ser-176/Ser-180, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000026822 ! inhibitor of nuclear factor kappa-B kinase subunit alpha isoform 1 phosphorylated 1
relationship: has_part MOD:00046 ! O-phospho-L-serine

[Term]
id: PR:000026820
name: inhibitor of nuclear factor kappa-B kinase subunit alpha isoform 1
def: "An inhibitor of nuclear factor kappa-B kinase subunit alpha that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O15111-1 or a 1:1 ortholog thereof." [PRO:CNx]
comment: Category=sequence.
synonym: "CHUK/iso:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000001775 ! inhibitor of nuclear factor kappa-B kinase subunit alpha

[Term]
id: PR:000001775
name: inhibitor of nuclear factor kappa-B kinase subunit alpha
def: "An inhibitor of nuclear factor kappa-B kinase complex alpha/beta subunits that is a translation product of the human CHUK gene or a 1:1 ortholog thereof." [PRO:CNA]
comment: Category=gene.
synonym: "CHUK" EXACT PRO-short-label [PRO:DNx]
synonym: "IKK1" EXACT []
synonym: "IKKA" RELATED Gene-based []
synonym: "IKK-A" EXACT []
synonym: "IkBKA" EXACT []
synonym: "TCF16" RELATED Gene-based []
synonym: "TCF-16" EXACT []
synonym: "NFKBIKA" EXACT []
synonym: "IKK-alpha" EXACT []
synonym: "IkappaB kinase" EXACT []
synonym: "I-kappa-B kinase 1" EXACT []
synonym: "I-kappa-B kinase alpha" EXACT []
synonym: "transcription factor 16" EXACT []
synonym: "conserved helix-loop-helix ubiquitous kinase" EXACT []
synonym: "nuclear factor NF-kappa-B inhibitor kinase alpha" EXACT []
xref: IUPHARobj:1989
is_a: PR:000001774 ! inhibitor of nuclear factor kappa-B kinase complex alpha/beta subunits

[Term]
id: PR:O15111-1
name: inhibitor of nuclear factor kappa-B kinase subunit alpha isoform 1 (human)
def: "An inhibitor of nuclear factor kappa-B kinase subunit alpha isoform 1 that is encoded in the genome of human." [PRO:CNx]
comment: Category=organism-sequence.
synonym: "hCHUK/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:O15111-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000026820 ! inhibitor of nuclear factor kappa-B kinase subunit alpha isoform 1

[Term]
id: PR:Q60680
name: inhibitor of nuclear factor kappa-B kinase subunit alpha (mouse)
def: "An inhibitor of nuclear factor kappa-B kinase subunit alpha that is encoded in the genome of mouse." [OMA:Q60680, PRO:DNx]
comment: Category=organism-gene.
synonym: "Chuk" RELATED Gene-based [UniProtKB:Q60680]
synonym: "Ikka" RELATED Gene-based [UniProtKB:Q60680]
synonym: "mCHUK" EXACT PRO-short-label [PRO:DNx]
synonym: "IKK1 (mouse)" EXACT [UniProtKB:Q60680]
synonym: "IKK-A (mouse)" EXACT [UniProtKB:Q60680]
synonym: "IkBKA (mouse)" EXACT [UniProtKB:Q60680]
synonym: "NFKBIKA (mouse)" EXACT [UniProtKB:Q60680]
synonym: "IKK-alpha (mouse)" EXACT [UniProtKB:Q60680]
synonym: "IkappaB kinase (mouse)" EXACT [UniProtKB:Q60680]
synonym: "I-kappa-B kinase 1 (mouse)" EXACT [UniProtKB:Q60680]
synonym: "I-kappa-B kinase alpha (mouse)" EXACT [UniProtKB:Q60680]
synonym: "conserved helix-loop-helix ubiquitous kinase (mouse)" EXACT [UniProtKB:Q60680]
synonym: "nuclear factor NF-kappa-B inhibitor kinase alpha (mouse)" EXACT [UniProtKB:Q60680]
xref: UniProtKB:Q60680
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000001775 ! inhibitor of nuclear factor kappa-B kinase subunit alpha
relationship: has_gene_template MGI:99484 ! Chuk (mouse)