[Term]
id: PR:Q14164
name: inhibitor of nuclear factor kappa-B kinase subunit epsilon (human)
def: "An inhibitor of nuclear factor kappa-B kinase subunit epsilon that is encoded in the genome of human." [PMID:10882136, PMID:17327220, PRO:CNA, UniProtKB:Q14164]
comment: Category=organism-gene.
synonym: "IKKE" RELATED Gene-based [UniProtKB:Q14164]
synonym: "IKKI" RELATED Gene-based [UniProtKB:Q14164]
synonym: "IKBKE" RELATED Gene-based [UniProtKB:Q14164]
synonym: "hIKBKE" EXACT PRO-short-label [PRO:DNx]
synonym: "KIAA0151" RELATED Gene-based [UniProtKB:Q14164]
synonym: "IKK-E (human)" EXACT []
synonym: "IKK-i (human)" EXACT []
synonym: "IkBKE (human)" EXACT []
synonym: "IKK-epsilon (human)" EXACT []
synonym: "I-kappa-B kinase epsilon (human)" EXACT []
synonym: "inducible I kappa-B kinase (human)" EXACT [UniProtKB:Q14164]
xref: Reactome:R-HSA-450225 "PR:Q14164 located_in GO:0005829"
xref: DTO:03100183
xref: UniProtKB:Q14164
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000001778 ! inhibitor of nuclear factor kappa-B kinase subunit epsilon
relationship: has_gene_template HGNC:14552 ! IKBKE (human)

[Term]
id: PR:Q9R0T8
name: inhibitor of nuclear factor kappa-B kinase subunit epsilon (mouse)
def: "An inhibitor of nuclear factor kappa-B kinase subunit epsilon that is encoded in the genome of mouse." [OMA:Q9R0T8, PRO:CNA]
comment: Category=organism-gene. Requested by=TLR.
synonym: "Ikke" RELATED Gene-based [UniProtKB:Q9R0T8]
synonym: "Ikki" RELATED Gene-based [UniProtKB:Q9R0T8]
synonym: "Ikbke" RELATED Gene-based [UniProtKB:Q9R0T8]
synonym: "mIKBKE" EXACT PRO-short-label [PRO:DNx]
synonym: "IKK-E (mouse)" EXACT []
synonym: "IKK-i (mouse)" EXACT []
synonym: "IkBKE (mouse)" EXACT []
synonym: "IKK-epsilon (mouse)" EXACT []
synonym: "I-kappa-B kinase epsilon (mouse)" EXACT []
synonym: "inducible I kappa-B kinase (mouse)" EXACT [UniProtKB:Q9R0T8]
xref: UniProtKB:Q9R0T8
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000001778 ! inhibitor of nuclear factor kappa-B kinase subunit epsilon
relationship: has_gene_template MGI:1929612 ! Ikbke (mouse)

[Term]
id: PR:Q14164-1
name: inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform 1 (human)
def: "An inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform 1 that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "hIKBKE/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q14164-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000028688 ! inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform 1

[Term]
id: PR:000001778
name: inhibitor of nuclear factor kappa-B kinase subunit epsilon
def: "An IKK-related kinase that is a translation product of the human IKBKE gene or a 1:1 ortholog thereof. Members of this class are part of the PMA-inducible IkappaB kinase complex." [PMID:10882136, PRO:CNA]
comment: Category=gene.
synonym: "IKKE" RELATED Gene-based []
synonym: "IKKI" RELATED Gene-based []
synonym: "IKBKE" EXACT PRO-short-label [PRO:DNx]
synonym: "IKK-E" EXACT []
synonym: "IKK-i" EXACT []
synonym: "IkBKE" EXACT []
synonym: "KIAA0151" RELATED Gene-based []
synonym: "IKK-epsilon" EXACT []
synonym: "I-kappa-B kinase epsilon" EXACT []
synonym: "inducible I kappa-B kinase" EXACT []
xref: IUPHARobj:2040
is_a: PR:000001777 ! IKK-related kinase

[Term]
id: PR:Q14164-2
name: inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform h2 (human)
def: "An inhibitor of nuclear factor kappa-B kinase subunit epsilon (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q14164-2." [PRO:DNx, UniProtKB:Q14164]
comment: Category=organism-sequence.
synonym: "hIKBKE/iso:h2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q14164-2
is_a: PR:Q14164 ! inhibitor of nuclear factor kappa-B kinase subunit epsilon (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000028688
name: inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform 1
def: "An inhibitor of nuclear factor kappa-B kinase subunit epsilon that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q14164-1 or a 1:1 ortholog thereof." [PRO:CNA]
comment: Category=sequence.
synonym: "IKBKE/iso:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000001778 ! inhibitor of nuclear factor kappa-B kinase subunit epsilon

[Term]
id: PR:000028691
name: inhibitor of nuclear factor kappa-B kinase subunit epsilon phosphorylated 1 (human)
def: "An inhibitor of nuclear factor kappa-B kinase subunit epsilon phosphorylated 1 in human. Example: UniProtKB:Q14164-1, Ser-172, MOD:00046." [PMID:10421793, PRO:CNA, Reactome:R-HSA-450278]
comment: Category=organism-modification.
synonym: "hIKBKE/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "p-S172-IKKE (human)" EXACT [Reactome:R-HSA-450278]
synonym: "p-S172-IKKi (human)" EXACT [Reactome:R-HSA-450278]
synonym: "UniProtKB:Q14164-1, Ser-172, MOD:00046" NARROW PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-450278 "PR:000028691 located_in GO:0010008"
xref: Reactome:R-HSA-4755521 "PR:000028691 located_in GO:0005654"
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000028690 ! inhibitor of nuclear factor kappa-B kinase subunit epsilon phosphorylated 1
relationship: has_part MOD:00046 ! O-phospho-L-serine

[Term]
id: PR:000028690
name: inhibitor of nuclear factor kappa-B kinase subunit epsilon phosphorylated 1
def: "An inhibitor of nuclear factor kappa-B kinase subunit epsilon that has been phosphorylated on a Ser residue by autocatalysis. Example: UniProtKB:Q14164-1, Ser-172, MOD:00046." [PRO:CNA, Reactome:R-HSA-450278]
comment: Category=modification.
synonym: "pIKKE" RELATED []
synonym: "p-IKKE" RELATED []
synonym: "p-IKKi" RELATED []
synonym: "IKBKE/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "phospho-IKKE" RELATED []
is_a: PR:000001778 ! inhibitor of nuclear factor kappa-B kinase subunit epsilon
relationship: has_part MOD:00046 ! O-phospho-L-serine