[Term]
id: PR:000021978
name: interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 4
def: "An interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated form in which the phosphorylation occurs by interleukin-1 receptor-associated kinase 4 (IRAK-4) and extensively autophosphorylated in the Pro-, Ser-, and Thr-rich ProST region between the N-terminal death domain and kinase domain. Example: UniProtKB:P51617-1, Thr-209/Thr-387, MOD:00047|MOD:00046." [PMID:14625308, PRO:CNA, PRO:DAN]
comment: Category=modification.
synonym: "hp-IRAK1" EXACT []
synonym: "IRAK1/iso:1/Phos:4" EXACT PRO-short-label [PRO:DNx]
synonym: "interleukin-1 receptor-associated kinase 1 hyperphosphorylated" EXACT []
is_a: PR:000021971 ! interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated form
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00047 ! O-phospho-L-threonine

[Term]
id: PR:000021971
name: interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated form
def: "An interleukin-1 receptor-associated kinase 1 isoform 1 that includes at least one phosphorylated residue." [PRO:CNA]
comment: Category=modification.
synonym: "IRAK1/iso:1/PhosRes+" EXACT PRO-short-label [PRO:DNx]
intersection_of: has_part MOD:00696 ! phosphorylated residue
intersection_of: PR:000021973 ! interleukin-1 receptor-associated kinase 1 isoform 1

[Term]
id: PR:000021973
name: interleukin-1 receptor-associated kinase 1 isoform 1
def: "An interleukin-1 receptor-associated kinase 1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P51617-1 or a 1:1 ortholog thereof." [PRO:CNA]
comment: Category=sequence.
synonym: "IRAK1/iso:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000001782 ! interleukin-1 receptor-associated kinase 1

[Term]
id: PR:000021975
name: interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 1
def: "An interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated form in which the phosphorylation by interleukin-1 receptor-associated kinase 4 (IRAK-4) occurs on the conserved Thr residue (Thr-209 in human) located at the N terminus of the kinase domain. This is the first step following the activation of the TLR/IL-1 receptor complex. This phosphorylation results in a conformational change of the kinase domain. Example: UniProtKB:P51617-1, Thr-209, MOD:00047." [PMID:11960013, PMID:14625308, PRO:CNA, TLR:AMM]
comment: Category=modification. Requested by=TLR.
synonym: "p-IRAK1" EXACT []
synonym: "IRAK1/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 2" EXACT []
is_a: PR:000021971 ! interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated form
relationship: has_part MOD:00047 ! O-phospho-L-threonine

[Term]
id: PR:000021974
name: interleukin-1 receptor-associated kinase 1 isoform 1 unmodified form
def: "An interleukin-1 receptor-associated kinase 1 isoform 1 that has not been subjected to any co- or post-translational residue modification or peptide bond cleavage." [PRO:CNA]
comment: Category=modification.
synonym: "IRAK1/iso:1/UnMod" EXACT PRO-short-label [PRO:DNx]
synonym: "interleukin-1 receptor-associated kinase 1 inactive" EXACT []
intersection_of: has_part PR:000021935 ! immature protein part
intersection_of: PR:000021973 ! interleukin-1 receptor-associated kinase 1 isoform 1
intersection_of: lacks_part PR:000025513 ! modified amino-acid residue
disjoint_from: PR:000018264 ! proteolytic cleavage product

[Term]
id: PR:000021977
name: interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 3
def: "An interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated form in which the phosphorylation by interleukin-1 receptor-associated kinase 4 (IRAK-4) occurs on the conserved Thr residue (Thr-209 in human) located near the N terminus of the kinase domain, and on a Thr residue located in the activation loop (Thr-387 in human). The latter phosphorylation is the second step following the activation of the TLR/IL-1 receptor complex. Example: UniProtKB:P51617-1, Thr-209/Thr-387, MOD:00047." [PMID:14625308, PRO:CNA, PRO:DAN]
comment: Category=modification.
synonym: "pp-IRAK1" EXACT []
synonym: "IRAK1/iso:1/Phos:3" EXACT PRO-short-label [PRO:DNx]
synonym: "interleukin-1 receptor-associated kinase 1 active" EXACT []
is_a: PR:000021971 ! interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated form
relationship: has_part MOD:00047 ! O-phospho-L-threonine

[Term]
id: PR:Q62406-1
name: interleukin-1 receptor-associated kinase 1 isoform 1 (mouse)
def: "An interleukin-1 receptor-associated kinase 1 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "mIRAK1/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q62406-1
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000021973 ! interleukin-1 receptor-associated kinase 1 isoform 1

[Term]
id: PR:000027179
name: interleukin-1 receptor-associated kinase 1 isoform 1 unmodified form (mouse)
def: "An interleukin-1 receptor-associated kinase 1 isoform 1 unmodified form in mouse." [PRO:CNA]
comment: Category=organism-modification.
synonym: "mIRAK1/iso:1/UnMod" EXACT PRO-short-label [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000021974 ! interleukin-1 receptor-associated kinase 1 isoform 1 unmodified form

[Term]
id: PR:000027178
name: interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 1 (mouse)
def: "An interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 1 in mouse. UniProtKB:Q62406-1, Thr-209, MOD:00047." [PMID:12538665, TLR:AMM]
comment: Category=organism-modification. Requested by=TLR.
synonym: "mIRAK1/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q62406-1, Thr-209, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000021975 ! interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 1
relationship: has_part MOD:00047 ! O-phospho-L-threonine

[Term]
id: PR:Q62406
name: interleukin-1 receptor-associated kinase 1 (mouse)
def: "An interleukin-1 receptor-associated kinase 1 that is encoded in the genome of mouse." [OMA:Q62406, PRO:CNA]
comment: Category=organism-gene.
synonym: "mPLK" EXACT [UniProtKB:Q62406]
synonym: "Irak1" RELATED Gene-based [UniProtKB:Q62406]
synonym: "Il1rak" RELATED Gene-based [UniProtKB:Q62406]
synonym: "mIRAK1" EXACT PRO-short-label [PRO:DNx]
synonym: "IRAK (mouse)" EXACT []
synonym: "IRAK-1 (mouse)" EXACT [UniProtKB:Q62406]
synonym: "pelle-like protein kinase (mouse)" EXACT [UniProtKB:Q62406]
xref: UniProtKB:Q62406
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000001782 ! interleukin-1 receptor-associated kinase 1
relationship: has_gene_template MGI:107420 ! Irak1 (mouse)

[Term]
id: PR:000027494
name: interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 1 (human)
def: "An interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 1 in human. UniProtKB:P51617-1, Thr-209, MOD:00047." [PRO:DNx, UniProtKB:P51617]
comment: Category=organism-modification.
synonym: "hIRAK1/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P51617-1, Thr-209, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000021975 ! interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 1
relationship: has_part MOD:00047 ! O-phospho-L-threonine

[Term]
id: PR:Q62406-2
name: interleukin-1 receptor-associated kinase 1 isoform m2 (mouse)
def: "An interleukin-1 receptor-associated kinase 1 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q62406-2." [PRO:DNx, UniProtKB:Q62406]
comment: Category=organism-sequence.
synonym: "mIRAK1/iso:m2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q62406-2
is_a: PR:Q62406 ! interleukin-1 receptor-associated kinase 1 (mouse)
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:000027492
name: interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 3 (human)
def: "An interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 3 in human. UniProtKB:P51617-1, Thr-209/Thr-387, MOD:00047." [PMID:14625308, PRO:CNA]
comment: Category=organism-modification.
synonym: "pp-IRAK1 (human)" EXACT []
synonym: "hIRAK1/iso:1/Phos:3" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P51617-1, Thr-209/Thr-387, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000021977 ! interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 3
relationship: has_part MOD:00047 ! O-phospho-L-threonine

[Term]
id: PR:000027493
name: interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 4 (human)
def: "An interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 4 in human. UniProtKB:P51617-1, Thr-209/Thr-387, MOD:00047|MOD:00046." [PMID:14625308, PRO:CNA]
comment: Category=organism-modification.
synonym: "hp-IRAK1 (human)" EXACT []
synonym: "hIRAK1/iso:1/Phos:4" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P51617-1, Thr-209/Thr-387, MOD:00047|MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000021978 ! interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 4
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00047 ! O-phospho-L-threonine

[Term]
id: PR:000048042
name: interleukin-1 receptor-associated kinase 1 phosphorylated 5 (human)
def: "An interleukin-1 receptor-associated kinase 1 (human) that has been phosphorylated on the residue at the position equivalent to Ser-376, and phosphothreonine at position 387 of the amino acid sequence represented by UniProtKB:P51617. UniProtKB:P51617, Ser-376, MOD:00046|Thr-387, MOD:00047." [PRO:DNx, Reactome:R-HSA-446687]
comment: Category=organism-modification.
synonym: "hIRAK1/Phos:5" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P51617, Ser-376, MOD:00046|Thr-387, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-446687 "PR:000048042 located_in GO:0005829"
is_a: PR:P51617 ! interleukin-1 receptor-associated kinase 1 (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000048043
name: interleukin-1 receptor-associated kinase 1 phosphorylated 1 (human)
def: "An interleukin-1 receptor-associated kinase 1 (human) that has been phosphorylated on the residue at the position equivalent to Thr-209 of the amino acid sequence represented by UniProtKB:P51617. UniProtKB:P51617, Thr-209, MOD:00047." [PRO:DNx, Reactome:R-HSA-937031, Reactome:R-HSA-975189]
comment: Category=organism-modification.
synonym: "hIRAK1/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P51617, Thr-209, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-937031 "PR:000048043 located_in GO:0005886"
xref: Reactome:R-HSA-975189 "PR:000048043 located_in GO:0010008"
is_a: PR:P51617 ! interleukin-1 receptor-associated kinase 1 (human)
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000048044
name: interleukin-1 receptor-associated kinase 1 phosphorylated 3 (human)
def: "An interleukin-1 receptor-associated kinase 1 (human) that has been post-translationally modified to include phosphothreonine at positions 209 and 387 of the amino acid sequence represented by UniProtKB:P51617. UniProtKB:P51617, Thr-209/Thr-387, MOD:00047." [PRO:DNx, Reactome:R-HSA-166279, Reactome:R-HSA-975117]
comment: Category=organism-modification.
synonym: "hIRAK1/Phos:3" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P51617, Thr-209/Thr-387, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-166279 "PR:000048044 located_in GO:0005886"
xref: Reactome:R-HSA-975117 "PR:000048044 located_in GO:0010008"
is_a: PR:P51617 ! interleukin-1 receptor-associated kinase 1 (human)
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P51617-1
name: interleukin-1 receptor-associated kinase 1 isoform 1 (human)
def: "An interleukin-1 receptor-associated kinase 1 isoform 1 that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "hIRAK1/iso:1" EXACT PRO-short-label [PRO:DNx]
synonym: "interleukin-1 receptor-associated kinase 1 isoform a (human)" EXACT [UniProtKB:P51617]
xref: UniProtKB:P51617-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000021973 ! interleukin-1 receptor-associated kinase 1 isoform 1

[Term]
id: PR:P51617-2
name: interleukin-1 receptor-associated kinase 1 isoform h2 (human)
def: "An interleukin-1 receptor-associated kinase 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P51617-2." [PRO:DNx, UniProtKB:P51617]
comment: Category=organism-sequence.
synonym: "hIRAK1/iso:h2" EXACT PRO-short-label [PRO:DNx]
synonym: "interleukin-1 receptor-associated kinase 1 isoform b (human)" EXACT [UniProtKB:P51617]
xref: UniProtKB:P51617-2
is_a: PR:P51617 ! interleukin-1 receptor-associated kinase 1 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P51617-3
name: interleukin-1 receptor-associated kinase 1 isoform h3 (human)
def: "An interleukin-1 receptor-associated kinase 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P51617-3." [PRO:DNx, UniProtKB:P51617]
comment: Category=organism-sequence.
synonym: "hIRAK1/iso:h3" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P51617-3
is_a: PR:P51617 ! interleukin-1 receptor-associated kinase 1 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P51617-4
name: interleukin-1 receptor-associated kinase 1 isoform h4 (human)
def: "An interleukin-1 receptor-associated kinase 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P51617-4." [PRO:DNx, UniProtKB:P51617]
comment: Category=organism-sequence.
synonym: "hIRAK1/iso:h4" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P51617-4
is_a: PR:P51617 ! interleukin-1 receptor-associated kinase 1 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P51617
name: interleukin-1 receptor-associated kinase 1 (human)
def: "An interleukin-1 receptor-associated kinase 1 that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-gene.
synonym: "IRAK" RELATED Gene-based [UniProtKB:P51617]
synonym: "IRAK1" RELATED Gene-based [UniProtKB:P51617]
synonym: "hIRAK1" EXACT PRO-short-label [PRO:DNx]
synonym: "IRAK-1 (human)" EXACT [UniProtKB:P51617]
xref: Reactome:R-HSA-937045 "PR:P51617 located_in GO:0005886"
xref: Reactome:R-HSA-975127 "PR:P51617 located_in GO:0010008"
xref: Reactome:R-HSA-446639 "PR:P51617 located_in GO:0005829"
xref: DTO:03100190
xref: UniProtKB:P51617
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000001782 ! interleukin-1 receptor-associated kinase 1
relationship: has_gene_template HGNC:6112 ! IRAK1 (human)

[Term]
id: PR:000001782
name: interleukin-1 receptor-associated kinase 1
def: "An interleukin-1 receptor-associated kinase IRAK1/3 that is a translation product of the human IRAK1 gene or a 1:1 ortholog thereof." [PRO:CNA]
comment: Category=gene.
synonym: "IRAK" RELATED Gene-based []
synonym: "IRAK1" EXACT PRO-short-label [PRO:DNx]
synonym: "IRAK-1" EXACT []
synonym: "Il1rak" RELATED Gene-based []
xref: IUPHARobj:2042
is_a: PR:000001781 ! interleukin-1 receptor-associated kinase IRAK1/3