[Term] id: PR:P16410-1 name: cytotoxic T-lymphocyte protein 4 isoform h1 (human) def: "A cytotoxic T-lymphocyte protein 4 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P16410-1." [PRO:DNx, UniProtKB:P16410] comment: Category=organism-sequence. synonym: "hCTLA4/iso:h1" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P16410-1 is_a: PR:P16410 ! cytotoxic T-lymphocyte protein 4 (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:P16410-2 name: cytotoxic T-lymphocyte protein 4 isoform h2 (human) def: "A cytotoxic T-lymphocyte protein 4 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P16410-2." [PRO:DNx, UniProtKB:P16410] comment: Category=organism-sequence. synonym: "hCTLA4/iso:h2" EXACT PRO-short-label [PRO:DNx] synonym: "cytotoxic T-lymphocyte protein 4 isoform ss-CTLA-4 (human)" EXACT [UniProtKB:P16410] xref: UniProtKB:P16410-2 is_a: PR:P16410 ! cytotoxic T-lymphocyte protein 4 (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:P16410-3 name: cytotoxic T-lymphocyte protein 4 isoform h3 (human) def: "A cytotoxic T-lymphocyte protein 4 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P16410-3." [PRO:DNx, UniProtKB:P16410] comment: Category=organism-sequence. synonym: "hCTLA4/iso:h3" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P16410-3 is_a: PR:P16410 ! cytotoxic T-lymphocyte protein 4 (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:P16410-4 name: cytotoxic T-lymphocyte protein 4 isoform h4 (human) def: "A cytotoxic T-lymphocyte protein 4 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P16410-4." [PRO:DNx, UniProtKB:P16410] comment: Category=organism-sequence. synonym: "hCTLA4/iso:h4" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P16410-4 is_a: PR:P16410 ! cytotoxic T-lymphocyte protein 4 (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:P16410 name: cytotoxic T-lymphocyte protein 4 (human) def: "A cytotoxic T-lymphocyte protein 4 that is encoded in the genome of human." [PRO:WCB, UniProtKB:P16410] comment: Category=organism-gene. synonym: "CD152" RELATED Gene-based [UniProtKB:P16410] synonym: "CTLA4" RELATED Gene-based [UniProtKB:P16410] synonym: "hCTLA4" EXACT PRO-short-label [PRO:DNx] synonym: "CTLA-4 (human)" EXACT [UniProtKB:P16410] synonym: "cytotoxic T-lymphocyte-associated antigen 4 (human)" EXACT [UniProtKB:P16410] xref: UniProtKB:P16410 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000001852 ! cytotoxic T-lymphocyte protein 4 relationship: has_gene_template HGNC:2505 ! CTLA4 (human) [Term] id: PR:000047094 name: cytotoxic T-lymphocyte protein 4, signal peptide removed form (human) def: "A cytotoxic T-lymphocyte protein 4 (human) that has had the signal peptide removed. UniProtKB:P16410, 36-223." [PRO:DNx, Reactome:R-HSA-179764] comment: Category=organism-modification. synonym: "PRO_0000014734" EXACT PRO-proteoform-ftid [PRO:DNx] synonym: "hCTLA4/SigPep-" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P16410, 36-223" EXACT PRO-proteoform-std [PRO:DNx] xref: Reactome:R-HSA-179764 "PR:000047094 located_in GO:0005886" intersection_of: PR:P16410 ! cytotoxic T-lymphocyte protein 4 (human) intersection_of: lacks_part SO:0000418 ! signal_peptide relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000047095 name: cytotoxic T-lymphocyte protein 4, signal peptide removed phosphorylated 1 (human) def: "A cytotoxic T-lymphocyte protein 4 (human) that has had the signal peptide removed and has been post-translationally modified to include phosphotyrosine at positions 201 and 218 of the amino acid sequence represented by UniProtKB:P16410. UniProtKB:P16410, 36-223, Tyr-201/Tyr-218, MOD:00048." [PRO:DAN, Reactome:R-HSA-388754] comment: Category=organism-modification. Note: The modified sites indicated here (Tyr-201/Tyr-218) are referred to as Tyr-165/Tyr-182 in the literature using the mouse sequence. [PRO:DAN, PMID:9712716] synonym: "hCTLA4/SigPep-/Phos:1" EXACT PRO-short-label [PRO:DNx] synonym: "PRO_0000014734, Tyr-201/Tyr-218, MOD:00048" EXACT PRO-proteoform-ftid [PRO:DNx] synonym: "UniProtKB:P16410, 36-223, Tyr-201/Tyr-218, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx] xref: Reactome:R-HSA-388754 "PR:000047095 located_in GO:0005886" is_a: PR:P16410 ! cytotoxic T-lymphocyte protein 4 (human) relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens relationship: lacks_part SO:0000418 ! signal_peptide [Term] id: PR:000001852 name: cytotoxic T-lymphocyte protein 4 def: "A protein that is a translation product of the human CTLA4 gene or a 1:1 ortholog thereof." [PRO:WCB] comment: Category=gene. Requested by=CL. synonym: "CD152" RELATED Gene-based [] synonym: "CTLA4" EXACT PRO-short-label [PRO:DNx] synonym: "CTLA-4" EXACT [] synonym: "cytotoxic T-lymphocyte-associated antigen 4" EXACT [] xref: IUPHARobj:2743 is_a: PR:000000001 ! protein [Term] id: PR:P16410-5 name: cytotoxic T-lymphocyte protein 4 isoform h5 (human) def: "A cytotoxic T-lymphocyte protein 4 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P16410-5." [PRO:DNx, UniProtKB:P16410] comment: Category=organism-sequence. synonym: "hCTLA4/iso:h5" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P16410-5 is_a: PR:P16410 ! cytotoxic T-lymphocyte protein 4 (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens