[Term]
id: PR:000001898
name: neprilysin
def: "A protein that is a translation product of the human MME gene or a 1:1 ortholog thereof." [PRO:WCB]
comment: Category=gene. Requested by=CL.
synonym: "EPN" RELATED Gene-based []
synonym: "MME" EXACT PRO-short-label [PRO:DNx]
synonym: "NEP" EXACT []
synonym: "SFE" EXACT []
synonym: "CD10" EXACT []
synonym: "CALLA" EXACT []
synonym: "enkephalinase" EXACT []
synonym: "atriopeptidase" EXACT []
synonym: "neutral endopeptidase" EXACT []
synonym: "skin fibroblast elastase" EXACT []
synonym: "neutral endopeptidase 24.11" EXACT []
synonym: "common acute lymphocytic leukemia antigen" EXACT []
xref: IUPHARobj:1611
xref: PIRSF:PIRSF501074
is_a: PR:000000001 ! protein

[Term]
id: PR:000045656
name: neprilysin phosphorylated 1 (human)
def: "A neprilysin (human) that has been phosphorylated at Ser-6. UniProtKB:P08473, Ser-6, MOD:00046." [PMID:20957047, iPTMnet:P08473]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:20957047). Status=unreviewed.
synonym: "hMME/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P08473, Ser-6, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:P08473 ! neprilysin (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P08473-1
name: neprilysin isoform 1 (human)
def: "A neprilysin isoform 1 that is encoded in the genome of human." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "hMME/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P08473-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000038738 ! neprilysin isoform 1

[Term]
id: PR:000048392
name: neprilysin, initiator methionine removed form (human)
def: "A neprilysin (human) that has had the initiator methionine removed. UniProtKB:P08473, 2-750." [PRO:DNx, Reactome:R-HSA-2022342]
comment: Category=organism-modification.
synonym: "hMME/InitMet-" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000078213" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P08473, 2-750" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-2022342 "PR:000048392 located_in GO:0005886"
xref: Reactome:R-HSA-6806156 "PR:000048392 located_in GO:0030667"
intersection_of: lacks_part PR:000021937 ! initiator methionine
intersection_of: PR:P08473 ! neprilysin (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P08473
name: neprilysin (human)
def: "A neprilysin that is encoded in the genome of human." [PRO:WCB, UniProtKB:P08473]
comment: Category=organism-gene.
synonym: "EPN" RELATED Gene-based [UniProtKB:P08473]
synonym: "MME" RELATED Gene-based [UniProtKB:P08473]
synonym: "hMME" EXACT PRO-short-label [PRO:DNx]
synonym: "NEP (human)" EXACT [UniProtKB:P08473]
synonym: "SFE (human)" EXACT [UniProtKB:P08473]
synonym: "CD10 (human)" EXACT [UniProtKB:P08473]
synonym: "CALLA (human)" EXACT [UniProtKB:P08473]
synonym: "enkephalinase (human)" EXACT [UniProtKB:P08473]
synonym: "atriopeptidase (human)" EXACT [UniProtKB:P08473]
synonym: "neutral endopeptidase (human)" EXACT [UniProtKB:P08473]
synonym: "skin fibroblast elastase (human)" EXACT [UniProtKB:P08473]
synonym: "neutral endopeptidase 24.11 (human)" EXACT [UniProtKB:P08473]
synonym: "common acute lymphocytic leukemia antigen (human)" EXACT [UniProtKB:P08473]
xref: UniProtKB:P08473
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000001898 ! neprilysin
relationship: has_gene_template HGNC:7154 ! MME (human)