[Term] id: PR:000002132 name: angiopoietin-1 receptor sequence variant Y897S (human) def: "An angiopoietin-1 receptor (human) that has a Ser residue at the position equivalent to Tyr-897 of the amino acid sequence represented by UniProtKB:Q02763-1. Example: UniProtKB:Q02763-1, Tyr-897, CHEBI:29999." [PMID:10369874, PRO:CNA, PRO:DAN] comment: Category=organism-sequence. synonym: "hTEK/var:Y897S" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:Q02763-1, Tyr-897, CHEBI:29999" NARROW PRO-proteoform-std [PRO:DAN] synonym: "angiopoietin-1 receptor sequence variant 2 (human)" EXACT [PRO:DNx] xref: UniProtKB_VAR:VAR_008716 is_a: PR:Q02763 ! angiopoietin-1 receptor (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000002131 name: angiopoietin-1 receptor sequence variant R849W (human) def: "An angiopoietin-1 receptor (human) that has a Trp residue at the position equivalent to Arg-849 of the amino acid sequence represented by UniProtKB:Q02763-1. Example: UniProtKB:Q02763-1, Arg-849, CHEBI:29954." [PMID:10369874, PMID:8980225, PMID:99199243, PRO:CNA, PRO:DAN] comment: Category=organism-sequence. synonym: "hTEK/var:R849W" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:Q02763-1, Arg-849, CHEBI:29954" NARROW PRO-proteoform-std [PRO:DAN] synonym: "angiopoietin-1 receptor sequence variant 1 (human)" EXACT [PRO:DNx] xref: UniProtKB_VAR:VAR_006352 is_a: PR:Q02763 ! angiopoietin-1 receptor (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:Q02763-3 name: angiopoietin-1 receptor isoform h3 (human) def: "An angiopoietin-1 receptor (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q02763-3." [PRO:DNx, UniProtKB:Q02763] comment: Category=organism-sequence. synonym: "hTEK/iso:h3" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q02763-3 is_a: PR:Q02763 ! angiopoietin-1 receptor (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:Q02763-2 name: angiopoietin-1 receptor isoform h2 (human) def: "An angiopoietin-1 receptor (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q02763-2." [PRO:DNx, UniProtKB:Q02763] comment: Category=organism-sequence. synonym: "hTEK/iso:h2" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q02763-2 is_a: PR:Q02763 ! angiopoietin-1 receptor (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:Q02763-1 name: angiopoietin-1 receptor isoform 1 (human) def: "An angiopoietin-1 receptor isoform 1 that is encoded in the genome of human." [PRO:CNA] comment: Category=organism-sequence. Requested by=PubChem. synonym: "hTEK/iso:1" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q02763-1 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000002130 ! angiopoietin-1 receptor isoform 1 [Term] id: PR:000049418 name: angiopoietin-1 receptor, signal peptide removed form (human) def: "An angiopoietin-1 receptor (human) that has had the signal peptide removed. UniProtKB:Q02763, 23-1124." [PRO:DNx, Reactome:R-HSA-197755] comment: Category=organism-modification. synonym: "hTEK/SigPep-" EXACT PRO-short-label [PRO:DNx] synonym: "PRO_0000024474" EXACT PRO-proteoform-ftid [PRO:DNx] synonym: "UniProtKB:Q02763, 23-1124" EXACT PRO-proteoform-std [PRO:DNx] xref: Reactome:R-HSA-197755 "PR:000049418 located_in GO:0005886" intersection_of: PR:Q02763 ! angiopoietin-1 receptor (human) intersection_of: lacks_part SO:0000418 ! signal_peptide relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000049419 name: angiopoietin-1 receptor, signal peptide removed phosphorylated 1 (human) def: "An angiopoietin-1 receptor (human) that has had the signal peptide removed and has been post-translationally modified to include phosphotyrosine at positions 816, 992, 1102, 1108 and 1113, and phosphoserine at position 1119 of the amino acid sequence represented by UniProtKB:Q02763. UniProtKB:Q02763, 23-1124, Tyr-816/Tyr-992/Tyr-1102/Tyr-1108/Tyr-1113, MOD:00048|Ser-1119, MOD:00046." [PRO:DNx, Reactome:R-HSA-204772] comment: Category=organism-modification. synonym: "hTEK/SigPep-/Phos:1" EXACT PRO-short-label [PRO:DNx] synonym: "PRO_0000024474, Tyr-816/Tyr-992/Tyr-1102/Tyr-1108/Tyr-1113, MOD:00048|Ser-1119, MOD:00046" EXACT PRO-proteoform-ftid [PRO:DNx] synonym: "UniProtKB:Q02763, 23-1124, Tyr-816/Tyr-992/Tyr-1102/Tyr-1108/Tyr-1113, MOD:00048|Ser-1119, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx] xref: Reactome:R-HSA-204772 "PR:000049419 located_in GO:0005886" is_a: PR:Q02763 ! angiopoietin-1 receptor (human) relationship: has_part MOD:00046 ! O-phospho-L-serine relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens relationship: lacks_part SO:0000418 ! signal_peptide [Term] id: PR:Q02763 name: angiopoietin-1 receptor (human) def: "An angiopoietin-1 receptor that is encoded in the genome of human." [PRO:WCB, UniProtKB:Q02763] comment: Category=organism-gene. synonym: "TEK" RELATED Gene-based [UniProtKB:Q02763] synonym: "TIE2" RELATED Gene-based [UniProtKB:Q02763] synonym: "VMCM" RELATED Gene-based [UniProtKB:Q02763] synonym: "hTEK" EXACT PRO-short-label [PRO:DNx] synonym: "VMCM1" RELATED Gene-based [UniProtKB:Q02763] synonym: "hTIE2" EXACT [UniProtKB:Q02763] synonym: "CD202b (human)" EXACT [UniProtKB:Q02763] synonym: "p140 TEK (human)" EXACT [UniProtKB:Q02763] synonym: "endothelial tyrosine kinase (human)" EXACT [UniProtKB:Q02763] synonym: "tyrosine-protein kinase receptor TEK (human)" EXACT [UniProtKB:Q02763] synonym: "tunica interna endothelial cell kinase (human)" EXACT [UniProtKB:Q02763] synonym: "tyrosine-protein kinase receptor TIE-2 (human)" EXACT [UniProtKB:Q02763] synonym: "tyrosine kinase with Ig and EGF homology domains-2 (human)" EXACT [UniProtKB:Q02763] xref: DTO:03100526 xref: UniProtKB:Q02763 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000002032 ! angiopoietin-1 receptor relationship: has_gene_template HGNC:11724 ! TEK (human) [Term] id: PR:000002032 name: angiopoietin-1 receptor def: "A receptor-type tyrosine-protein kinase Tie that is a translation product of the human TEK gene or a 1:1 ortholog thereof." [PRO:WCB] comment: Category=gene. synonym: "HYK" EXACT [] synonym: "TEK" EXACT PRO-short-label [PRO:DNx] synonym: "STK1" RELATED [] synonym: "TIE2" RELATED Gene-based [] synonym: "VMCM" RELATED Gene-based [] synonym: "Tie-2" RELATED Gene-based [] synonym: "VMCM1" RELATED Gene-based [] synonym: "CD202b" EXACT [] synonym: "p140 TEK" EXACT [] synonym: "endothelial tyrosine kinase" EXACT [] synonym: "tyrosine-protein kinase receptor TEK" EXACT [] synonym: "tunica interna endothelial cell kinase" EXACT [] synonym: "tyrosine-protein kinase receptor TIE-2" EXACT [] synonym: "tyrosine kinase with Ig and EGF homology domains-2" EXACT [] xref: IUPHARobj:1842 is_a: PR:000001923 ! receptor-type tyrosine-protein kinase Tie [Term] id: PR:000056851 name: angiopoietin-1 receptor N-glycosylated 1 (human) def: "An angiopoietin-1 receptor (human) that has been N-glycosylated at the residue equivalent to Asn-649 of the amino acid sequence represented by UniProtKB:Q02763-1, in which the glycan composition is represented by GlyTouCan:G58001LT. Example: UniProtKB:Q02763-1, Asn-649, MOD:00160~GNO:G58001LT." [GlyGen:Q02763-1, PMID:23345538, PRO:DNx] comment: Category=organism-modification. Requested by=GlyGen. synonym: "hTEK/NGlyco:1" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:Q02763-1, Asn-649, MOD:00160~GNO:G58001LT" NARROW PRO-proteoform-std [PRO:DNx] is_a: PR:Q02763 ! angiopoietin-1 receptor (human) relationship: has_part GNO:G58001LT ! G58001LT relationship: has_part MOD:00160 ! N4-glycosyl-L-asparagine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens