[Term]
id: PR:000048048
name: interferon regulatory factor 3 phosphorylated 4 (human)
def: "An interferon regulatory factor 3 (human) that has been post-translationally modified to include phosphoserine at positions 396, 398, 402 and 405, and phosphothreonine at position 404 of the amino acid sequence represented by UniProtKB:Q14653. UniProtKB:Q14653, Ser-396/Ser-398/Ser-402/Ser-405, MOD:00046|Thr-404, MOD:00047." [PRO:DNx, Reactome:R-HSA-166258, Reactome:R-HSA-177654]
comment: Category=organism-modification.
synonym: "hIRF3/Phos:4" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q14653, Ser-396/Ser-398/Ser-402/Ser-405, MOD:00046|Thr-404, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-166258 "PR:000048048 located_in GO:0005829"
xref: Reactome:R-HSA-177654 "PR:000048048 located_in GO:0005654"
is_a: PR:Q14653 ! interferon regulatory factor 3 (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P70671
name: interferon regulatory factor 3 (mouse)
def: "An interferon regulatory factor 3 that is encoded in the genome of mouse." [OMA:P70671, PRO:CNA]
comment: Category=organism-gene.
synonym: "Irf3" RELATED Gene-based [UniProtKB:P70671]
synonym: "mIRF3" EXACT PRO-short-label [PRO:DNx]
synonym: "IRF-3 (mouse)" EXACT [UniProtKB:P70671]
xref: UniProtKB:P70671
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000002045 ! interferon regulatory factor 3
relationship: has_gene_template MGI:1859179 ! Irf3 (mouse)

[Term]
id: PR:000002045
name: interferon regulatory factor 3
def: "An interferon regulatory factor 3-9 that is a translation product of the human IRF3 gene or a 1:1 ortholog thereof." [PRO:WCB]
comment: Category=gene.
synonym: "IRF3" EXACT PRO-short-label [PRO:DNx]
synonym: "IRF-3" EXACT []
is_a: PR:000001863 ! interferon regulatory factor 3-9

[Term]
id: PR:Q14653-4
name: interferon regulatory factor 3 isoform h4 (human)
def: "An interferon regulatory factor 3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q14653-4." [PRO:DNx, UniProtKB:Q14653]
comment: Category=organism-sequence.
synonym: "hIRF3/iso:h4" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q14653-4
is_a: PR:Q14653 ! interferon regulatory factor 3 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q14653-5
name: interferon regulatory factor 3 isoform h5 (human)
def: "An interferon regulatory factor 3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q14653-5." [PRO:DNx, UniProtKB:Q14653]
comment: Category=organism-sequence.
synonym: "hIRF3/iso:h5" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q14653-5
is_a: PR:Q14653 ! interferon regulatory factor 3 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000003260
name: interferon regulatory factor 3 isoform 1 phosphorylated 1
def: "An interferon regulatory factor 3 isoform 1 phosphorylated form in which the phosphorylation occurs upon stimulation by virus infection or treatment with double-stranded RNA or LPS. Phosphorylation stimulates the C-terminal autoinhibitory domain to attain a highly extended conformation triggering dimerization through extensive contacts to a second subunit. Example: UniProtKB:Q14653-1, Ser-385/Ser-386, MOD:00046." [PMID:14703513, PMID:20043992, TLR:AMM]
comment: Category=modification. Requested by=TLR.
synonym: "phospho IRF3" EXACT []
synonym: "IRF3 active form" EXACT []
synonym: "IRF3/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000003259 ! interferon regulatory factor 3 isoform 1 phosphorylated form
relationship: has_part MOD:00046 ! O-phospho-L-serine

[Term]
id: PR:Q14653-2
name: interferon regulatory factor 3 isoform h2 (human)
def: "An interferon regulatory factor 3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q14653-2." [PRO:DNx, UniProtKB:Q14653]
comment: Category=organism-sequence.
synonym: "hIRF3/iso:h2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q14653-2
is_a: PR:Q14653 ! interferon regulatory factor 3 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000025763
name: interferon regulatory factor 3 isoform 1 phosphorylated 1 (human)
def: "An interferon regulatory factor 3 isoform 1 phosphorylated 1 in human. UniProtKB:Q14653-1, Ser-385/Ser-386, MOD:00046." [PMID:10805757, PRO:CNA]
comment: Category=organism-modification.
synonym: "IRF3-P (human)" EXACT []
synonym: "hIRF3/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q14653-1, Ser-385/Ser-386, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000003260 ! interferon regulatory factor 3 isoform 1 phosphorylated 1
relationship: has_part MOD:00046 ! O-phospho-L-serine

[Term]
id: PR:Q14653-1
name: interferon regulatory factor 3 isoform 1 (human)
def: "An interferon regulatory factor 3 isoform 1 that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "hIRF3/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q14653-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000003257 ! interferon regulatory factor 3 isoform 1

[Term]
id: PR:000003257
name: interferon regulatory factor 3 isoform 1
def: "An interferon regulatory factor 3 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q14653-1 or a 1:1 ortholog thereof." [PRO:CNA]
comment: Category=sequence.
synonym: "IRF3/iso:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000002045 ! interferon regulatory factor 3

[Term]
id: PR:C0IXK2
name: interferon regulatory factor 3 isoform 2 (mouse)
def: "An interferon regulatory factor 3 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:C0IXK2." [PMID:18851954, PRO:HJD]
comment: Category=organism-sequence. Evidence=(ECO:0000006, based on PMID:18851954). Note: An alternative donor site within exon 6 of mIrf-3 gene is utilized to produce mIRF-3a, resulting in a much shorter exon 6, a downstream frameshift compared to mIRF-3 isoform 1 and consequent premature termination of translation.
synonym: "mIRF-3a" EXACT [PMID:18851954]
synonym: "mIRF3/iso:2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:C0IXK2
is_a: PR:P70671 ! interferon regulatory factor 3 (mouse)
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:Q14653-3
name: interferon regulatory factor 3 isoform h3 (human)
def: "An interferon regulatory factor 3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q14653-3." [PRO:DNx, UniProtKB:Q14653]
comment: Category=organism-sequence.
synonym: "hIRF3/iso:h3" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q14653-3
is_a: PR:Q14653 ! interferon regulatory factor 3 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000027097
name: interferon regulatory factor 3 isoform 1 phosphorylated 1 (mouse)
def: "An interferon regulatory factor 3 isoform 1 phosphorylated 1 in mouse. UniProtKB:P70671-1, Ser-378/Ser-379, MOD:00046." [PMID:12872135, PRO:CNA]
comment: Category=organism-modification. Evidence=(ECO:0000250, based on PR:000025763).
synonym: "IRF3-P (mouse)" EXACT []
synonym: "mIRF3/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P70671-1, Ser-378/Ser-379, MOD:00046" EXACT PRO-proteoform-std [PRO:DAN]
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000003260 ! interferon regulatory factor 3 isoform 1 phosphorylated 1
relationship: has_part MOD:00046 ! O-phospho-L-serine

[Term]
id: PR:P70671-1
name: interferon regulatory factor 3 isoform 1 (mouse)
def: "An interferon regulatory factor 3 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "mIRF3/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P70671-1
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000003257 ! interferon regulatory factor 3 isoform 1

[Term]
id: PR:Q14653
name: interferon regulatory factor 3 (human)
def: "An interferon regulatory factor 3 that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-gene.
synonym: "IRF3" RELATED Gene-based [UniProtKB:Q14653]
synonym: "hIRF3" EXACT PRO-short-label [PRO:DNx]
synonym: "IRF-3 (human)" EXACT [UniProtKB:Q14653]
xref: Reactome:R-HSA-166251 "PR:Q14653 located_in GO:0005829"
xref: UniProtKB:Q14653
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000002045 ! interferon regulatory factor 3
relationship: has_gene_template HGNC:6118 ! IRF3 (human)

[Term]
id: PR:000045488
name: interferon regulatory factor 3 phosphorylated 1 (human)
def: "An interferon regulatory factor 3 (human) that has been phosphorylated in Ser and Thr residues within the two phosphorylation cluster sites. A Ser (Ser-386 in UniProtKB:Q14653-1) on the 2S site and multiple Ser and Thr residues in the 5ST site (Ser-396, Ser-498, Ser-402, Thr-404, and Ser-405 in UniProtKB:Q14653-1). Example: UniProtKB:Q14653-1, Ser-386/Ser-398/Ser-402/Ser-405, MOD:00046|Thr-404, MOD:00047." [PRO:CNA, Reactome:R-HSA-166258, Reactome:R-HSA-177654]
comment: Category=organism-modification.
synonym: "hIRF3/Phos:1" EXACT PRO-short-label [PRO:DAN]
synonym: "p-4S,T404-IRF3 (human)" RELATED []
synonym: "UniProtKB:Q14653-1, Ser-386/Ser-398/Ser-402/Ser-405, MOD:00046|Thr-404, MOD:00047" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:Q14653 ! interferon regulatory factor 3 (human)
disjoint_from: PR:Q14653-3 ! interferon regulatory factor 3 isoform h3 (human)
disjoint_from: PR:Q14653-4 ! interferon regulatory factor 3 isoform h4 (human)
disjoint_from: PR:Q14653-5 ! interferon regulatory factor 3 isoform h5 (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000028701
name: interferon regulatory factor 3 unmodified form
def: "An interferon regulatory factor 3 that has not been subjected to any co- or post-translational residue modification or peptide bond cleavage." [PRO:CNA]
comment: Category=modification.
synonym: "IRF3/UnMod" EXACT PRO-short-label [PRO:DNx]
intersection_of: PR:000002045 ! interferon regulatory factor 3
intersection_of: has_part PR:000021935 ! immature protein part
intersection_of: lacks_part PR:000025513 ! modified amino-acid residue
disjoint_from: PR:000018264 ! proteolytic cleavage product

[Term]
id: PR:000003259
name: interferon regulatory factor 3 isoform 1 phosphorylated form
def: "An interferon regulatory factor 3 isoform 1 that includes at least one phosphorylated residue." [PRO:CNA]
comment: Category=modification.
synonym: "IRF3/iso:1/PhosRes+" EXACT PRO-short-label [PRO:DNx]
intersection_of: has_part MOD:00696 ! phosphorylated residue
intersection_of: PR:000003257 ! interferon regulatory factor 3 isoform 1

[Term]
id: PR:000045489
name: interferon regulatory factor 3 isoform 1 phosphorylated 2 (human)
def: "An interferon regulatory factor 3 isoform 1 (human) that has been phosphorylated in Ser-339 and Ser and Thr residues within the two phosphorylation cluster sites. A Ser-386 on the 2S site and multiple Ser and Thr residues in the 5ST site (Ser-396, Ser-498, Ser-402, Thr-404, and Ser-405). UniProtKB:Q14653-1, Ser-339/Ser-386/Ser-398/Ser-402/Ser-405, MOD:00046|Thr-404, MOD:00047." [PRO:CNA, Reactome:R-HSA-936418]
comment: Category=organism-modification. Note: Reactome does not specify the precise isoform. However, it mentions that this proteoform is involved in dimerization. Based on the positions of the modified residues, and based on the position of the dimerization domain (203-385), only isoform 1 is eligible. [PRO:DAN, PMID:23824805]
synonym: "hIRF3/iso:1/Phos:2" EXACT PRO-short-label [PRO:DAN]
synonym: "p-5S,T404-IRF3 (human)" RELATED []
synonym: "UniProtKB:Q14653-1, Ser-339/Ser-386/Ser-398/Ser-402/Ser-405, MOD:00046|Thr-404, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-936418 "PR:000045489 located_in GO:0005654"
is_a: PR:Q14653-1 ! interferon regulatory factor 3 isoform 1 (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000028702
name: interferon regulatory factor 3 unmodified form (human)
def: "An interferon regulatory factor 3 unmodified form in human." [PRO:CNA]
comment: Category=organism-modification.
synonym: "hIRF3/UnMod" EXACT PRO-short-label [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000028701 ! interferon regulatory factor 3 unmodified form