[Term]
id: PR:P04626-6
name: receptor tyrosine-protein kinase erbB-2 isoform h6 (human)
def: "A receptor tyrosine-protein kinase erbB-2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P04626-6." [PRO:DNx, UniProtKB:P04626]
comment: Category=organism-sequence.
synonym: "hERBB2/iso:h6" EXACT PRO-short-label [PRO:DNx]
synonym: "receptor tyrosine-protein kinase erbB-2 isoform B (human)" EXACT [UniProtKB:P04626]
xref: UniProtKB:P04626-6
is_a: PR:P04626 ! receptor tyrosine-protein kinase erbB-2 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000047317
name: receptor tyrosine-protein kinase erbB-2, signal peptide removed form (human)
def: "A receptor tyrosine-protein kinase erbB-2 (human) that has had the signal peptide removed. UniProtKB:P04626, 23-1255." [PRO:DNx, Reactome:R-HSA-372889]
comment: Category=organism-modification.
synonym: "PRO_0000016669" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "hERBB2/SigPep-" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P04626, 23-1255" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-372889 "PR:000047317 located_in GO:0005886"
intersection_of: PR:P04626 ! receptor tyrosine-protein kinase erbB-2 (human)
intersection_of: lacks_part SO:0000418 ! signal_peptide
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000045637
name: receptor tyrosine-protein kinase erbB-2 phosphorylated 1 (human)
def: "A receptor tyrosine-protein kinase erbB-2 (human) that has been phosphorylated on the residue at the position equivalent to Thr-686 of the amino acid sequence represented by UniProtKB:P04626-1. Example: UniProtKB:P04626-1, Thr-686, MOD:00047." [PMID:18799465, iPTMnet:P04626]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:18799465). Status=unreviewed.
synonym: "hERBB2/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P04626-1, Thr-686, MOD:00047" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P04626 ! receptor tyrosine-protein kinase erbB-2 (human)
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P04626-2
name: receptor tyrosine-protein kinase erbB-2 isoform h2 (human)
def: "A receptor tyrosine-protein kinase erbB-2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P04626-2." [PRO:DNx, UniProtKB:P04626]
comment: Category=organism-sequence.
synonym: "hERBB2/iso:h2" EXACT PRO-short-label [PRO:DNx]
synonym: "receptor tyrosine-protein kinase erbB-2 isoform CTF-611 (human)" EXACT [UniProtKB:P04626]
xref: UniProtKB:P04626-2
is_a: PR:P04626 ! receptor tyrosine-protein kinase erbB-2 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P04626-3
name: receptor tyrosine-protein kinase erbB-2 isoform h3 (human)
def: "A receptor tyrosine-protein kinase erbB-2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P04626-3." [PRO:DNx, UniProtKB:P04626]
comment: Category=organism-sequence.
synonym: "hERBB2/iso:h3" EXACT PRO-short-label [PRO:DNx]
synonym: "receptor tyrosine-protein kinase erbB-2 isoform CTF-687 (human)" EXACT [UniProtKB:P04626]
xref: UniProtKB:P04626-3
is_a: PR:P04626 ! receptor tyrosine-protein kinase erbB-2 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P04626-1
name: receptor tyrosine-protein kinase erbB-2 isoform h1 (human)
def: "A receptor tyrosine-protein kinase erbB-2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P04626-1." [PRO:DNx, UniProtKB:P04626]
comment: Category=organism-sequence.
synonym: "hERBB2/iso:h1" EXACT PRO-short-label [PRO:DNx]
synonym: "receptor tyrosine-protein kinase erbB-2 isoform HER2 (human)" EXACT [UniProtKB:P04626]
synonym: "receptor tyrosine-protein kinase erbB-2 isoform ERBB2 (human)" EXACT [UniProtKB:P04626]
xref: UniProtKB:P04626-1
is_a: PR:P04626 ! receptor tyrosine-protein kinase erbB-2 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000047319
name: receptor tyrosine-protein kinase erbB-2, signal peptide removed phosphorylated 3 (human)
def: "A receptor tyrosine-protein kinase erbB-2 (human) that has had the signal peptide removed and has been post-translationally modified to include phosphotyrosine at positions 1023, 1139, 1196, 1221, 1222 and 1248 of the amino acid sequence represented by UniProtKB:P04626. UniProtKB:P04626, 23-1255, Tyr-1023/Tyr-1139/Tyr-1196/Tyr-1221/Tyr-1222/Tyr-1248, MOD:00048." [PRO:DNx, Reactome:R-HSA-1963569]
comment: Category=organism-modification.
synonym: "hERBB2/SigPep-/Phos:3" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000016669, Tyr-1023/Tyr-1139/Tyr-1196/Tyr-1221/Tyr-1222/Tyr-1248, MOD:00048" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P04626, 23-1255, Tyr-1023/Tyr-1139/Tyr-1196/Tyr-1221/Tyr-1222/Tyr-1248, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-1963569 "PR:000047319 located_in GO:0005886"
is_a: PR:P04626 ! receptor tyrosine-protein kinase erbB-2 (human)
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part SO:0000418 ! signal_peptide

[Term]
id: PR:P04626
name: receptor tyrosine-protein kinase erbB-2 (human)
def: "A receptor tyrosine-protein kinase erbB-2 that is encoded in the genome of human." [PRO:WCB, UniProtKB:P04626]
comment: Category=organism-gene.
synonym: "NEU" RELATED Gene-based [UniProtKB:P04626]
synonym: "NGL" RELATED Gene-based [UniProtKB:P04626]
synonym: "HER2" RELATED Gene-based [UniProtKB:P04626]
synonym: "ERBB2" RELATED Gene-based [UniProtKB:P04626]
synonym: "MLN19" RELATED Gene-based [UniProtKB:P04626]
synonym: "hERBB2" EXACT PRO-short-label [PRO:DNx]
synonym: "CD340 (human)" EXACT [UniProtKB:P04626]
synonym: "MLN 19 (human)" EXACT [UniProtKB:P04626]
synonym: "p185erbB2 (human)" EXACT [UniProtKB:P04626]
synonym: "proto-oncogene Neu (human)" EXACT [UniProtKB:P04626]
synonym: "proto-oncogene c-ErbB-2 (human)" EXACT [UniProtKB:P04626]
synonym: "metastatic lymph node gene 19 protein (human)" EXACT [UniProtKB:P04626]
synonym: "tyrosine kinase-type cell surface receptor HER2 (human)" EXACT [UniProtKB:P04626]
xref: DTO:03100139
xref: UniProtKB:P04626
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000002082 ! receptor tyrosine-protein kinase erbB-2
relationship: has_gene_template HGNC:3430 ! ERBB2 (human)

[Term]
id: PR:000002082
name: receptor tyrosine-protein kinase erbB-2
def: "An EGF receptor type tyrosine-protein kinase that is a translation product of the human ERBB2 gene or a 1:1 ortholog thereof." [PRO:WCB]
comment: Category=gene.
synonym: "NEU" RELATED Gene-based []
synonym: "NGL" RELATED Gene-based []
synonym: "HER2" RELATED Gene-based []
synonym: "CD340" EXACT []
synonym: "ERBB2" EXACT PRO-short-label [PRO:DNx]
synonym: "MLN19" RELATED Gene-based []
synonym: "MLN 19" EXACT []
synonym: "Kiaa3023" RELATED Gene-based []
synonym: "p185erbB2" EXACT []
synonym: "proto-oncogene Neu" EXACT []
synonym: "proto-oncogene c-ErbB-2" EXACT []
synonym: "metastatic lymph node gene 19 protein" EXACT []
synonym: "tyrosine kinase-type cell surface receptor HER2" EXACT []
xref: IUPHARobj:2019
is_a: PR:000001812 ! EGF receptor type tyrosine-protein kinase

[Term]
id: PR:000047318
name: receptor tyrosine-protein kinase erbB-2, signal peptide removed phosphorylated 2 (human)
def: "A receptor tyrosine-protein kinase erbB-2 (human) that has had the signal peptide removed and has been post-translationally modified to include phosphotyrosine at positions 1023, 1112, 1139, 1196, 1221, 1222 and 1248 of the amino acid sequence represented by UniProtKB:P04626. UniProtKB:P04626, 23-1255, Tyr-1023/Tyr-1112/Tyr-1139/Tyr-1196/Tyr-1221/Tyr-1222/Tyr-1248, MOD:00048." [PRO:DNx, Reactome:R-HSA-8864081]
comment: Category=organism-modification.
synonym: "hERBB2/SigPep-/Phos:2" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000016669, Tyr-1023/Tyr-1112/Tyr-1139/Tyr-1196/Tyr-1221/Tyr-1222/Tyr-1248, MOD:00048" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P04626, 23-1255, Tyr-1023/Tyr-1112/Tyr-1139/Tyr-1196/Tyr-1221/Tyr-1222/Tyr-1248, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-8864081 "PR:000047318 located_in GO:0005886"
is_a: PR:P04626 ! receptor tyrosine-protein kinase erbB-2 (human)
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part SO:0000418 ! signal_peptide

[Term]
id: PR:000047322
name: receptor tyrosine-protein kinase erbB-2, signal peptide removed phosphorylated 6 (human)
def: "A receptor tyrosine-protein kinase erbB-2 (human) that has had the signal peptide removed and has been post-translationally modified to include phosphotyrosine at positions 877, 1023, 1139, 1196, 1221, 1222 and 1248 of the amino acid sequence represented by UniProtKB:P04626. UniProtKB:P04626, 23-1255, Tyr-877/Tyr-1023/Tyr-1139/Tyr-1196/Tyr-1221/Tyr-1222/Tyr-1248, MOD:00048." [PRO:DNx, Reactome:R-HSA-1248698]
comment: Category=organism-modification.
synonym: "hERBB2/SigPep-/Phos:6" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000016669, Tyr-877/Tyr-1023/Tyr-1139/Tyr-1196/Tyr-1221/Tyr-1222/Tyr-1248, MOD:00048" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P04626, 23-1255, Tyr-877/Tyr-1023/Tyr-1139/Tyr-1196/Tyr-1221/Tyr-1222/Tyr-1248, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-1248698 "PR:000047322 located_in GO:0005886"
is_a: PR:P04626 ! receptor tyrosine-protein kinase erbB-2 (human)
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part SO:0000418 ! signal_peptide

[Term]
id: PR:000047321
name: receptor tyrosine-protein kinase erbB-2, signal peptide removed phosphorylated 5 (human)
def: "A receptor tyrosine-protein kinase erbB-2 (human) that has had the signal peptide removed and has been post-translationally modified to include phosphotyrosine at positions 877, 1023, 1112, 1139, 1196, 1221, 1222 and 1248 of the amino acid sequence represented by UniProtKB:P04626. UniProtKB:P04626, 23-1255, Tyr-877/Tyr-1023/Tyr-1112/Tyr-1139/Tyr-1196/Tyr-1221/Tyr-1222/Tyr-1248, MOD:00048." [PRO:DNx, Reactome:R-HSA-8864079]
comment: Category=organism-modification.
synonym: "hERBB2/SigPep-/Phos:5" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000016669, Tyr-877/Tyr-1023/Tyr-1112/Tyr-1139/Tyr-1196/Tyr-1221/Tyr-1222/Tyr-1248, MOD:00048" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P04626, 23-1255, Tyr-877/Tyr-1023/Tyr-1112/Tyr-1139/Tyr-1196/Tyr-1221/Tyr-1222/Tyr-1248, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-8864079 "PR:000047321 located_in GO:0005886"
is_a: PR:P04626 ! receptor tyrosine-protein kinase erbB-2 (human)
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part SO:0000418 ! signal_peptide

[Term]
id: PR:P06494
name: receptor tyrosine-protein kinase erbB-2 (rat)
def: "A receptor tyrosine-protein kinase erbB-2 that is encoded in the genome of rat." [PANTHER:PTHR24416:SF287, PRO:DNx]
comment: Category=organism-gene.
synonym: "Neu" RELATED Gene-based [UniProtKB:P06494]
synonym: "Erbb2" RELATED Gene-based [UniProtKB:P06494]
synonym: "rERBB2" EXACT PRO-short-label [PRO:DNx]
synonym: "CD340 (rat)" EXACT [UniProtKB:P06494]
synonym: "p185neu (rat)" EXACT [UniProtKB:P06494]
synonym: "p185erbB2 (rat)" EXACT [UniProtKB:P06494]
synonym: "proto-oncogene Neu (rat)" EXACT [UniProtKB:P06494]
synonym: "proto-oncogene c-ErbB-2 (rat)" EXACT [UniProtKB:P06494]
synonym: "epidermal growth factor receptor-related protein (rat)" EXACT [UniProtKB:P06494]
xref: UniProtKB:P06494
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000002082 ! receptor tyrosine-protein kinase erbB-2
relationship: has_gene_template RGD:2561 ! Erbb2 (rat)

[Term]
id: PR:000044845
name: receptor tyrosine-protein kinase erbB-2 phosphotyrosine form (mouse)
def: "A receptor tyrosine-protein kinase erbB-2 (mouse) that includes at least one phosphorylated tyrosine. UniProtKB:P70424, MOD:00048." [PMID:21186272, PRO:KRC]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:21186272). Evidence=(ECO:0000178, based on PMID:21186272).
synonym: "mERBB2/PhosTyr+" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P70424, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx]
synonym: "erbb2 Y-phosphorylated (mouse)" RELATED []
intersection_of: has_part MOD:00048 ! O4'-phospho-L-tyrosine
intersection_of: PR:P70424 ! receptor tyrosine-protein kinase erbB-2 (mouse)
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:Q2EJ72
name: receptor protein-tyrosine kinase erbB-2 (chicken)
def: "A receptor tyrosine-protein kinase erbB-2 that is encoded in the genome of chicken." [PANTHER:PTHR24416:SF287, PRO:DNx]
comment: Category=organism-gene.
synonym: "chick-ERBB2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q2EJ72
intersection_of: only_in_taxon NCBITaxon:9031 ! Gallus gallus
intersection_of: PR:000002082 ! receptor tyrosine-protein kinase erbB-2
relationship: has_gene_template CGNC:13679 ! ERBB2 (chicken)

[Term]
id: PR:P04626-5
name: receptor tyrosine-protein kinase erbB-2 isoform h5 (human)
def: "A receptor tyrosine-protein kinase erbB-2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P04626-5." [PRO:DNx, UniProtKB:P04626]
comment: Category=organism-sequence.
synonym: "hERBB2/iso:h5" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P04626-5
is_a: PR:P04626 ! receptor tyrosine-protein kinase erbB-2 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000047320
name: receptor tyrosine-protein kinase erbB-2, signal peptide removed phosphorylated 4 (human)
def: "A receptor tyrosine-protein kinase erbB-2 (human) that has had the signal peptide removed and has been post-translationally modified to include phosphotyrosine at position 877 of the amino acid sequence represented by UniProtKB:P04626. UniProtKB:P04626, 23-1255, Tyr-877, MOD:00048." [PRO:DNx, Reactome:R-HSA-1810438]
comment: Category=organism-modification.
synonym: "hERBB2/SigPep-/Phos:4" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000016669, Tyr-877, MOD:00048" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P04626, 23-1255, Tyr-877, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-1810438 "PR:000047320 located_in GO:0005886"
is_a: PR:P04626 ! receptor tyrosine-protein kinase erbB-2 (human)
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part SO:0000418 ! signal_peptide

[Term]
id: PR:000053406
name: receptor tyrosine-protein kinase erbB-2 O-glycosylated 1 (human)
def: "A receptor tyrosine-protein kinase erbB-2 (human) that has been O-glycosylated at the residue equivalent to Thr-127 of the amino acid sequence represented by UniProtKB:P04626-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P04626-1, Thr-127, MOD:00005~GNO:G43417UB." [GlyGen:P04626-1, PMID:30459171, PRO:DNx]
comment: Category=organism-modification. Requested by=GlyGen.
synonym: "hERBB2/OGlyco:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P04626-1, Thr-127, MOD:00005~GNO:G43417UB" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P04626 ! receptor tyrosine-protein kinase erbB-2 (human)
relationship: has_part GNO:G43417UB ! G43417UB
relationship: has_part MOD:00005 ! O-glycosyl-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P70424
name: receptor tyrosine-protein kinase erbB-2 (mouse)
def: "A receptor tyrosine-protein kinase erbB-2 that is encoded in the genome of mouse." [OMA:P70424, PRO:DNx]
comment: Category=organism-gene.
synonym: "Neu" RELATED Gene-based [UniProtKB:P70424]
synonym: "Erbb2" RELATED Gene-based [UniProtKB:P70424]
synonym: "mERBB2" EXACT PRO-short-label [PRO:DNx]
synonym: "Kiaa3023" RELATED Gene-based [UniProtKB:P70424]
synonym: "CD340 (mouse)" EXACT [UniProtKB:P70424]
synonym: "p185erbB2 (mouse)" EXACT [UniProtKB:P70424]
synonym: "proto-oncogene Neu (mouse)" EXACT [UniProtKB:P70424]
synonym: "proto-oncogene c-ErbB-2 (mouse)" EXACT [UniProtKB:P70424]
xref: UniProtKB:P70424
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000002082 ! receptor tyrosine-protein kinase erbB-2
relationship: has_gene_template MGI:95410 ! Erbb2 (mouse)

[Term]
id: PR:P04626-4
name: receptor tyrosine-protein kinase erbB-2 isoform h4 (human)
def: "A receptor tyrosine-protein kinase erbB-2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P04626-4." [PRO:DNx, UniProtKB:P04626]
comment: Category=organism-sequence.
synonym: "hERBB2/iso:h4" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P04626-4
is_a: PR:P04626 ! receptor tyrosine-protein kinase erbB-2 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000047323
name: receptor tyrosine-protein kinase erbB-2, signal peptide removed phosphotyrosine form (human)
def: "A receptor tyrosine-protein kinase erbB-2 (human) that has had the signal peptide removed and that includes at least one phosphorylated tyrosine. UniProtKB:P04626, 23-1255, MOD:00048." [PRO:DNx, Reactome:R-HSA-1678589]
comment: Category=organism-modification.
synonym: "hERBB2/SigPep-/PhosTyr+" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000016669, MOD:00048" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P04626, 23-1255, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-1678589 "PR:000047323 located_in GO:0005886"
intersection_of: has_part MOD:00048 ! O4'-phospho-L-tyrosine
intersection_of: PR:P04626 ! receptor tyrosine-protein kinase erbB-2 (human)
intersection_of: lacks_part SO:0000418 ! signal_peptide
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens