[Term]
id: PR:P42227-1
name: signal transducer and activator of transcription 3 isoform Stat3A (mouse)
def: "A signal transducer and activator of transcription 3 isoform 1 that is encoded in the genome of mouse." [PRO:DNx, UniProtKB:P42227]
comment: Category=organism-sequence.
synonym: "mSTAT3/iso:Stat3A" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P42227-1
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000027921 ! signal transducer and activator of transcription 3 isoform 1

[Term]
id: PR:Q6DV79
name: signal transducer and activator of transcription 3 (chicken)
def: "A signal transducer and activator of transcription 3 that is encoded in the genome of chicken." [OMA:Q6DV79, PANTHER:PTHR11801:SF17, PRO:DNx]
comment: Category=organism-gene.
synonym: "STAT3" RELATED Gene-based [UniProtKB:Q6DV79]
synonym: "chick-STAT3" EXACT PRO-short-label [PRO:DNx]
synonym: "RCJMB04_38l20" RELATED Gene-based [UniProtKB:Q6DV79]
xref: UniProtKB:Q6DV79
intersection_of: only_in_taxon NCBITaxon:9031 ! Gallus gallus
intersection_of: PR:000002089 ! signal transducer and activator of transcription 3
relationship: has_gene_template NCBIGene:420027 ! STAT3 (chicken)

[Term]
id: PR:000037009
name: signal transducer and activator of transcription 3 isoform Stat3A phosphorylated 1 (mouse)
def: "A signal transducer and activator of transcription 3 isoform Stat3A (mouse) that has been phosphorylated on a residue equivalent to UniProtKB:P42227-1 Tyr-705. UniProtKB:P42227-1, Tyr-705, MOD:00048." [PMID:26026268, PRO:HJD]
comment: Category=organism-modification.
synonym: "mSTAT3/iso:Stat3A/Phos:1" EXACT PRO-short-label [PRO:DAN]
synonym: "UniProtKB:P42227-1, Tyr-705, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:P42227-1 ! signal transducer and activator of transcription 3 isoform Stat3A (mouse)
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:000002089
name: signal transducer and activator of transcription 3
def: "A signal transducer and transcription activator STAT that is a translation product of the human STAT3 gene or a 1:1 ortholog thereof." [PRO:WCB]
comment: Category=gene.
synonym: "APRF" RELATED Gene-based []
synonym: "STAT3" EXACT PRO-short-label [PRO:DNx]
synonym: "acute-phase response factor" EXACT []
is_a: PR:000001933 ! signal transducer and transcription activator STAT

[Term]
id: PR:000027924
name: signal transducer and activator of transcription 3 isoform 1 acetylated 1 (human)
def: "A signal transducer and activator of transcription 3 isoform 1 acetylated 1 in human. UniProtKB:P40763-1, Lys-685, MOD:00064." [KAT:P40763, PMID:15653507, PMID:19506034]
comment: Category=organism-modification. Acetylase=("EP300"; PR:Q09472; Lys-685).
synonym: "STAT3-AcLys685" EXACT []
synonym: "hSTAT3/iso:1/Ac:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P40763-1, Lys-685, MOD:00064" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000027923 ! signal transducer and activator of transcription 3 isoform 1 acetylated 1
relationship: has_part MOD:00064 ! N6-acetyl-L-lysine

[Term]
id: PR:P40763-3
name: signal transducer and activator of transcription 3 isoform h3 (human)
def: "A signal transducer and activator of transcription 3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P40763-3." [PRO:DNx, UniProtKB:P40763]
comment: Category=organism-sequence.
synonym: "hSTAT3/iso:h3" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P40763-3
is_a: PR:P40763 ! signal transducer and activator of transcription 3 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P40763-1
name: signal transducer and activator of transcription 3 isoform 1 (human)
def: "A signal transducer and activator of transcription 3 isoform 1 that is encoded in the genome of human." [KAT:P40763]
comment: Category=organism-sequence.
synonym: "hSTAT3/iso:1" EXACT PRO-short-label [PRO:DNx]
synonym: "STAT3 isoform 1 (human)" EXACT []
xref: UniProtKB:P40763-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000027921 ! signal transducer and activator of transcription 3 isoform 1

[Term]
id: PR:P42227
name: signal transducer and activator of transcription 3 (mouse)
def: "A signal transducer and activator of transcription 3 that is encoded in the genome of mouse." [OMA:P42227, PRO:DNx]
comment: Category=organism-gene.
synonym: "Aprf" RELATED Gene-based [UniProtKB:P42227]
synonym: "Stat3" RELATED Gene-based [UniProtKB:P42227]
synonym: "mSTAT3" EXACT PRO-short-label [PRO:DNx]
synonym: "acute-phase response factor (mouse)" EXACT [UniProtKB:P42227]
xref: UniProtKB:P42227
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000002089 ! signal transducer and activator of transcription 3
relationship: has_gene_template MGI:103038 ! Stat3 (mouse)

[Term]
id: PR:000027921
name: signal transducer and activator of transcription 3 isoform 1
def: "A signal transducer and activator of transcription 3 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P40763-1 or a 1:1 ortholog thereof." [KAT:P40763, PMID:15653507, PMID:19506034]
comment: Category=sequence.
synonym: "STAT3/iso:1" EXACT PRO-short-label [PRO:DNx]
synonym: "STAT3 isoform 1" EXACT []
is_a: PR:000002089 ! signal transducer and activator of transcription 3

[Term]
id: PR:000027923
name: signal transducer and activator of transcription 3 isoform 1 acetylated 1
def: "A signal transducer and activator of transcription 3 isoform 1 that has been acetylated on a Lys residue within the conserved sequence FGKYC, and elicited by the internalization of CD44. Example: UniProtKB:P40763-1, Lys-685, MOD:00064." [KAT:P40763, PMID:15653507, PMID:19506034]
comment: Category=modification.
synonym: "STAT3 acetylated" RELATED []
synonym: "STAT3/iso:1/Ac:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000027921 ! signal transducer and activator of transcription 3 isoform 1
relationship: has_part MOD:00064 ! N6-acetyl-L-lysine

[Term]
id: PR:P40763-2
name: signal transducer and activator of transcription 3 isoform Del-701 (human)
def: "A signal transducer and activator of transcription 3 isoform Del-701 that is encoded in the genome of human." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "hSTAT3/iso:Del-701" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P40763-2
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000039402 ! signal transducer and activator of transcription 3 isoform Del-701

[Term]
id: PR:P42227-3
name: signal transducer and activator of transcription 3 isoform Del-701 (mouse)
def: "A signal transducer and activator of transcription 3 isoform Del-701 that is encoded in the genome of mouse." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "mSTAT3/iso:Del-701" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P42227-3
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000039402 ! signal transducer and activator of transcription 3 isoform Del-701

[Term]
id: PR:000045774
name: signal transducer and activator of transcription 3 phosphorylated 1 (human)
def: "A signal transducer and activator of transcription 3 (human) that has been phosphorylated on the residue at the position equivalent to Tyr-705 of the amino acid sequence represented by UniProtKB:P40763-1. Example: UniProtKB:P40763-1, Tyr-705, MOD:00048." [PMID:22306293, PMID:9083098, iPTMnet:P40763]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:22306293, PMID:9083098). Status=unreviewed.
synonym: "hSTAT3/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P40763-1, Tyr-705, MOD:00048" NARROW PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-914048 "PR:000045774 located_in GO:0005829"
xref: Reactome:R-HSA-1112554 "PR:000045774 located_in GO:0005654"
is_a: PR:P40763 ! signal transducer and activator of transcription 3 (human)
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000045779
name: signal transducer and activator of transcription 3 isoform Stat3A phosphorylated 2 (mouse)
def: "A signal transducer and activator of transcription 3 isoform Stat3A (mouse) that has been phosphorylated at Ser-727 of the amino acid sequence represented by UniProtKB:P42227-1. UniProtKB:P42227-1, Ser-727, MOD:00046." [PMID:14617800, PMID:15096606, PRO:CNA, iPTMnet:P42227]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:14617800, PMID:15096606).
synonym: "mSTAT3/iso:Stat3A/Phos:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P42227-1, Ser-727, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:P42227-1 ! signal transducer and activator of transcription 3 isoform Stat3A (mouse)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:P52631
name: signal transducer and activator of transcription 3 (rat)
def: "A signal transducer and activator of transcription 3 that is encoded in the genome of rat." [OMA:P52631, PANTHER:PTHR11801:SF17, PRO:DNx]
comment: Category=organism-gene.
synonym: "Stat3" RELATED Gene-based [UniProtKB:P52631]
synonym: "rSTAT3" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P52631
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000002089 ! signal transducer and activator of transcription 3
relationship: has_gene_template RGD:3772 ! Stat3 (rat)

[Term]
id: PR:P40763
name: signal transducer and activator of transcription 3 (human)
def: "A signal transducer and activator of transcription 3 that is encoded in the genome of human." [PRO:WCB, UniProtKB:P40763]
comment: Category=organism-gene.
synonym: "APRF" RELATED Gene-based [UniProtKB:P40763]
synonym: "STAT3" RELATED Gene-based [UniProtKB:P40763]
synonym: "hSTAT3" EXACT PRO-short-label [PRO:DNx]
synonym: "acute-phase response factor (human)" EXACT [UniProtKB:P40763]
xref: Reactome:R-HSA-539044 "PR:P40763 located_in GO:0005829"
xref: UniProtKB:P40763
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000002089 ! signal transducer and activator of transcription 3
relationship: has_gene_template HGNC:11364 ! STAT3 (human)

[Term]
id: PR:000049779
name: signal transducer and activator of transcription 3 isoform Stat3A unphosphorylated 2 (mouse)
def: "A signal transducer and activator of transcription 3 isoform Stat3A (mouse) that lacks phosphorylation at the position equivalent to Ser-727. UniProtKB:P42227-1, Ser-727, PR:000026291." [PMID:26764350, PRO:HJD]
comment: Category=organism-modification.
synonym: "mSTAT3/iso:Stat3A/UnPhos:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P42227-1, Ser-727, PR:000026291" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:P42227-1 ! signal transducer and activator of transcription 3 isoform Stat3A (mouse)
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:000049778
name: signal transducer and activator of transcription 3 isoform Stat3A unphosphorylated 1 (mouse)
def: "A signal transducer and activator of transcription 3 isoform Stat3A (mouse) that lacks phosphorylation at position Tyr-705. UniProtKB:P42227-1, Tyr-705, PR:000026291." [PMID:26764350, PRO:HJD]
comment: Category=organism-modification.
synonym: "mSTAT3/iso:Stat3A/UnPhos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P42227-1, Tyr-705, PR:000026291" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:P42227-1 ! signal transducer and activator of transcription 3 isoform Stat3A (mouse)
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:000039402
name: signal transducer and activator of transcription 3 isoform Del-701
def: "A signal transducer and activator of transcription 3 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P40763-2 or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=sequence.
synonym: "STAT3 isoform 2" EXACT [PRO:DNx]
synonym: "STAT3/iso:Del-701" EXACT PRO-short-label [PRO:DNx]
synonym: "signal transducer and activator of transcription 3 isoform 2" EXACT [PRO:DNx]
is_a: PR:000002089 ! signal transducer and activator of transcription 3

[Term]
id: PR:P42227-2
name: signal transducer and activator of transcription 3 isoform mStat3B (mouse)
def: "A signal transducer and activator of transcription 3 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P42227-2." [PRO:DNx, UniProtKB:P42227]
comment: Category=organism-sequence.
synonym: "mSTAT3/iso:mStat3B" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P42227-2
is_a: PR:P42227 ! signal transducer and activator of transcription 3 (mouse)
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus