[Term]
id: PR:000002217
name: tumor necrosis factor ligand superfamily member 11 isoform 1
def: "A tumor necrosis factor ligand superfamily member 11 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O35235-1 or a 1:1 ortholog thereof." [PRO:JAN]
comment: Category=sequence.
synonym: "RANKL 1" RELATED []
synonym: "TNFSF11/iso:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000002107 ! tumor necrosis factor ligand superfamily member 11

[Term]
id: PR:000002220
name: tumor necrosis factor ligand superfamily member 11 isoform 4
def: "A tumor necrosis factor ligand superfamily member 11 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O14788-2 or a 1:1 ortholog thereof." [PRO:JAN]
comment: Category=sequence.
synonym: "SODF" EXACT []
synonym: "TNFSF11/iso:4" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000002107 ! tumor necrosis factor ligand superfamily member 11

[Term]
id: PR:000002221
name: tumor necrosis factor ligand superfamily member 11 isoform 5
def: "A tumor necrosis factor ligand superfamily member 11 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O14788-3 or a 1:1 ortholog thereof." [PRO:JAN]
comment: Category=sequence.
synonym: "TNFSF11/iso:5" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000002107 ! tumor necrosis factor ligand superfamily member 11

[Term]
id: PR:O14788-3
name: tumor necrosis factor ligand superfamily member 11 isoform 3 (human)
def: "A tumor necrosis factor ligand superfamily member 11 isoform 5 that is encoded in the genome of human." [PRO:JAN]
comment: Category=organism-sequence.
synonym: "hTNFSF11/iso:3" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:O14788-3
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000002221 ! tumor necrosis factor ligand superfamily member 11 isoform 5

[Term]
id: PR:O14788-2
name: tumor necrosis factor ligand superfamily member 11 isoform 2 (human)
def: "A tumor necrosis factor ligand superfamily member 11 isoform 4 that is encoded in the genome of human." [PRO:JAN]
comment: Category=organism-sequence.
synonym: "hTNFSF11/iso:2" EXACT PRO-short-label [PRO:DNx]
synonym: "tumor necrosis factor ligand superfamily member 11 isoform SODF (human)" EXACT [UniProtKB:O14788]
xref: UniProtKB:O14788-2
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000002220 ! tumor necrosis factor ligand superfamily member 11 isoform 4

[Term]
id: PR:O14788-1
name: tumor necrosis factor ligand superfamily member 11 isoform 1 (human)
def: "A tumor necrosis factor ligand superfamily member 11 isoform 1 that is encoded in the genome of human." [PRO:JAN]
comment: Category=organism-sequence.
synonym: "hTNFSF11/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:O14788-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000002217 ! tumor necrosis factor ligand superfamily member 11 isoform 1

[Term]
id: PR:A3RF19
name: tumor necrosis factor ligand superfamily member 11 (chicken)
def: "A tumor necrosis factor ligand superfamily member 11 that is encoded in the genome of chicken." [PANTHER:PTHR11471:SF3, PRO:DNx]
comment: Category=organism-gene.
synonym: "chick-TNFSF11" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:A3RF19
intersection_of: only_in_taxon NCBITaxon:9031 ! Gallus gallus
intersection_of: PR:000002107 ! tumor necrosis factor ligand superfamily member 11
relationship: has_gene_template CGNC:66545 ! TNFSF11 (chicken)

[Term]
id: PR:000002107
name: tumor necrosis factor ligand superfamily member 11
def: "A tumor necrosis factor ligand superfamily member 10/11 that is a translation product of the human TNFSF11 gene or a 1:1 ortholog thereof." [PRO:WCB]
comment: Category=gene.
synonym: "ODF" EXACT []
synonym: "OPGL" RELATED Gene-based []
synonym: "CD254" EXACT []
synonym: "RANKL" RELATED Gene-based []
synonym: "TRANCE" RELATED Gene-based []
synonym: "TNFSF11" EXACT PRO-short-label [PRO:DNx]
synonym: "osteoprotegerin ligand" EXACT []
synonym: "osteoclast differentiation factor" EXACT []
synonym: "TNF-related activation-induced cytokine" EXACT []
synonym: "receptor activator of nuclear factor kappa-B ligand" EXACT []
is_a: PR:000001946 ! tumor necrosis factor ligand superfamily member 10/11

[Term]
id: PR:O35235
name: tumor necrosis factor ligand superfamily member 11 (mouse)
def: "A tumor necrosis factor ligand superfamily member 11 that is encoded in the genome of mouse." [OMA:O35235, PRO:DNx]
comment: Category=organism-gene.
synonym: "Opgl" RELATED Gene-based [UniProtKB:O35235]
synonym: "Rankl" RELATED Gene-based [UniProtKB:O35235]
synonym: "Trance" RELATED Gene-based [UniProtKB:O35235]
synonym: "Tnfsf11" RELATED Gene-based [UniProtKB:O35235]
synonym: "mTNFSF11" EXACT PRO-short-label [PRO:DNx]
synonym: "ODF (mouse)" EXACT [UniProtKB:O35235]
synonym: "OPGL (mouse)" EXACT [UniProtKB:O35235]
synonym: "CD254 (mouse)" EXACT [UniProtKB:O35235]
synonym: "RANKL (mouse)" EXACT [UniProtKB:O35235]
synonym: "TRANCE (mouse)" EXACT [UniProtKB:O35235]
synonym: "osteoprotegerin ligand (mouse)" EXACT [UniProtKB:O35235]
synonym: "osteoclast differentiation factor (mouse)" EXACT [UniProtKB:O35235]
synonym: "TNF-related activation-induced cytokine (mouse)" EXACT [UniProtKB:O35235]
synonym: "receptor activator of nuclear factor kappa-B ligand (mouse)" EXACT [UniProtKB:O35235]
xref: UniProtKB:O35235
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000002107 ! tumor necrosis factor ligand superfamily member 11
relationship: has_gene_template MGI:1100089 ! Tnfsf11 (mouse)

[Term]
id: PR:000002219
name: tumor necrosis factor ligand superfamily member 11 isoform 3
def: "A tumor necrosis factor ligand superfamily member 11 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O35235-3 or a 1:1 ortholog thereof." [PMID:11250921, PRO:DAN, PRO:JAN]
comment: Category=sequence.
synonym: "RANKL 3" EXACT []
synonym: "TNFSF11/iso:3" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000002107 ! tumor necrosis factor ligand superfamily member 11

[Term]
id: PR:000002218
name: tumor necrosis factor ligand superfamily member 11 isoform 2
def: "A tumor necrosis factor ligand superfamily member 11 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O35235-2 or a 1:1 ortholog thereof." [PRO:JAN]
comment: Category=sequence.
synonym: "RANKL 2" EXACT []
synonym: "TNFSF11/iso:2" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000002107 ! tumor necrosis factor ligand superfamily member 11

[Term]
id: PR:000002437
name: tumor necrosis factor ligand superfamily member 11 isoform 1 soluble form
def: "A tumor necrosis factor ligand superfamily member 11 isoform 1 that has been processed by a metalloprotease-disintegrin TNF-alpha convertase (TACE) to yield the tumor necrosis factor ligand superfamily member 11 soluble form." [PMID:10196481]
comment: Category=modification.
synonym: "TNFSF11 soluble form" BROAD [PRO:DNx]
synonym: "TNFSF11/iso:1/Clv:soluble" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000002217 ! tumor necrosis factor ligand superfamily member 11 isoform 1
relationship: output_of GO:0016485 ! protein processing

[Term]
id: PR:000018721
name: tumor necrosis factor ligand superfamily member 11 proteolytic cleavage product
def: "A tumor necrosis factor ligand superfamily member 11 that has been processed by proteolytic cleavage." [PRO:DNx]
comment: Category=modification.
synonym: "TNFSF11/ClvPrd" EXACT PRO-short-label [PRO:DNx]
intersection_of: output_of GO:0016485 ! protein processing
intersection_of: PR:000002107 ! tumor necrosis factor ligand superfamily member 11

[Term]
id: PR:O35235-3
name: tumor necrosis factor ligand superfamily member 11 isoform 3 (mouse)
def: "A tumor necrosis factor ligand superfamily member 11 isoform 3 that is encoded in the genome of mouse." [PRO:JAN]
comment: Category=organism-sequence.
synonym: "mTNFSF11/iso:3" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:O35235-3
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000002219 ! tumor necrosis factor ligand superfamily member 11 isoform 3

[Term]
id: PR:O35235-2
name: tumor necrosis factor ligand superfamily member 11 isoform 2 (mouse)
def: "A tumor necrosis factor ligand superfamily member 11 isoform 2 that is encoded in the genome of mouse." [PRO:JAN]
comment: Category=organism-sequence.
synonym: "mTNFSF11/iso:2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:O35235-2
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000002218 ! tumor necrosis factor ligand superfamily member 11 isoform 2

[Term]
id: PR:O35235-1
name: tumor necrosis factor ligand superfamily member 11 isoform 1 (mouse)
def: "A tumor necrosis factor ligand superfamily member 11 isoform 1 that is encoded in the genome of mouse." [PRO:JAN]
comment: Category=organism-sequence.
synonym: "mTNFSF11/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:O35235-1
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000002217 ! tumor necrosis factor ligand superfamily member 11 isoform 1

[Term]
id: PR:O14788
name: tumor necrosis factor ligand superfamily member 11 (human)
def: "A tumor necrosis factor ligand superfamily member 11 that is encoded in the genome of human." [PRO:WCB, UniProtKB:O14788]
comment: Category=organism-gene.
synonym: "OPGL" RELATED Gene-based [UniProtKB:O14788]
synonym: "RANKL" RELATED Gene-based [UniProtKB:O14788]
synonym: "TRANCE" RELATED Gene-based [UniProtKB:O14788]
synonym: "TNFSF11" RELATED Gene-based [UniProtKB:O14788]
synonym: "hTNFSF11" EXACT PRO-short-label [PRO:DNx]
synonym: "ODF (human)" EXACT [UniProtKB:O14788]
synonym: "CD254 (human)" EXACT [UniProtKB:O14788]
synonym: "osteoprotegerin ligand (human)" EXACT [UniProtKB:O14788]
synonym: "osteoclast differentiation factor (human)" EXACT [UniProtKB:O14788]
synonym: "TNF-related activation-induced cytokine (human)" EXACT [UniProtKB:O14788]
synonym: "receptor activator of nuclear factor kappa-B ligand (human)" EXACT [UniProtKB:O14788]
xref: Reactome:R-HSA-5667141 "PR:O14788 located_in GO:0005886"
xref: UniProtKB:O14788
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000002107 ! tumor necrosis factor ligand superfamily member 11
relationship: has_gene_template HGNC:11926 ! TNFSF11 (human)

[Term]
id: PR:Q9ESE2
name: tumor necrosis factor ligand superfamily member 11 (rat)
def: "A tumor necrosis factor ligand superfamily member 11 that is encoded in the genome of rat." [PANTHER:PTHR11471:SF3, PRO:DNx]
comment: Category=organism-gene.
synonym: "Opgl" RELATED Gene-based [UniProtKB:Q9ESE2]
synonym: "Rankl" RELATED Gene-based [UniProtKB:Q9ESE2]
synonym: "Trance" RELATED Gene-based [UniProtKB:Q9ESE2]
synonym: "Tnfsf11" RELATED Gene-based [UniProtKB:Q9ESE2]
synonym: "rTNFSF11" EXACT PRO-short-label [PRO:DNx]
synonym: "ODF (rat)" EXACT [UniProtKB:Q9ESE2]
synonym: "OPGL (rat)" EXACT [UniProtKB:Q9ESE2]
synonym: "CD254 (rat)" EXACT [UniProtKB:Q9ESE2]
synonym: "RANKL (rat)" EXACT [UniProtKB:Q9ESE2]
synonym: "TRANCE (rat)" EXACT [UniProtKB:Q9ESE2]
synonym: "osteoprotegerin ligand (rat)" EXACT [UniProtKB:Q9ESE2]
synonym: "osteoclast differentiation factor (rat)" EXACT [UniProtKB:Q9ESE2]
synonym: "TNF-related activation-induced cytokine (rat)" EXACT [UniProtKB:Q9ESE2]
synonym: "receptor activator of nuclear factor kappa-B ligand (rat)" EXACT [UniProtKB:Q9ESE2]
xref: UniProtKB:Q9ESE2
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000002107 ! tumor necrosis factor ligand superfamily member 11
relationship: has_gene_template RGD:620784 ! Tnfsf11 (rat)

[Term]
id: PR:000002438
name: tumor necrosis factor ligand superfamily member 11 isoform 1 membrane-anchored form
def: "A tumor necrosis factor ligand superfamily member 11 isoform 1 that has not been processed by a metalloprotease-disintegrin TNF-alpha convertase (TACE), and thus remains a full-length, membrane-anchored form." [PMID:10196481, PRO:DAN]
comment: Category=modification.
synonym: "TNFSF11 membrane form" BROAD [PRO:DNx]
synonym: "TNFSF11/iso:1/membrane" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000002217 ! tumor necrosis factor ligand superfamily member 11 isoform 1
disjoint_from: PR:000018264 ! proteolytic cleavage product