[Term] id: PR:000002450 name: caspase-1 isoform 1 cleaved 2 def: "A caspase-1 isoform 1 that has been processed by proteolytic cleavage to yield the mature caspase-1 subunit p10." [PMID:8044845, PRO:JAN] comment: Category=modification. synonym: "CASP1/iso:1/Clv:2" EXACT PRO-short-label [PRO:DNx] synonym: "caspase-1 subunit p10" EXACT [] is_a: PR:000002390 ! caspase-1 isoform 1 relationship: output_of GO:0016485 ! protein processing [Term] id: PR:P43527 name: caspase-1 (rat) def: "A caspase-1 that is encoded in the genome of rat." [PANTHER:PTHR10454:SF13, PRO:DNx] comment: Category=organism-gene. synonym: "Casp1" RELATED Gene-based [UniProtKB:P43527] synonym: "Il1bc" RELATED Gene-based [UniProtKB:P43527] synonym: "Il1bce" RELATED Gene-based [UniProtKB:P43527] synonym: "rCASP1" EXACT PRO-short-label [PRO:DNx] synonym: "ICE (rat)" EXACT [UniProtKB:P43527] synonym: "p45 (rat)" BROAD [UniProtKB:P43527] synonym: "CASP-1 (rat)" EXACT [UniProtKB:P43527] synonym: "IL-1BC (rat)" EXACT [UniProtKB:P43527] synonym: "IL-1 beta-converting enzyme (rat)" EXACT [UniProtKB:P43527] synonym: "interleukin-1 beta convertase (rat)" EXACT [UniProtKB:P43527] synonym: "interleukin-1 beta-converting enzyme (rat)" EXACT [UniProtKB:P43527] xref: UniProtKB:P43527 intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus intersection_of: PR:000002309 ! caspase-1 relationship: has_gene_template RGD:2274 ! Casp1 (rat) [Term] id: PR:P29466-4 name: caspase-1 isoform delta (human) def: "A caspase-1 isoform 4 that is encoded in the genome of human." [PRO:JAN] comment: Category=organism-sequence. synonym: "hCASP1/iso:delta" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P29466-4 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000002393 ! caspase-1 isoform 4 [Term] id: PR:P29466-5 name: caspase-1 isoform epsilon (human) def: "A caspase-1 isoform 5 that is encoded in the genome of human." [PRO:JAN] comment: Category=organism-sequence. synonym: "hCASP1/iso:epsilon" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P29466-5 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000002394 ! caspase-1 isoform 5 [Term] id: PR:P29452 name: caspase-1 (mouse) def: "A caspase-1 that is encoded in the genome of mouse." [OMA:P29452, PRO:DNx] comment: Category=organism-gene. synonym: "Casp1" RELATED Gene-based [UniProtKB:P29452] synonym: "Il1bc" RELATED Gene-based [UniProtKB:P29452] synonym: "mCASP1" EXACT PRO-short-label [PRO:DNx] synonym: "ICE (mouse)" EXACT [UniProtKB:P29452] synonym: "p45 (mouse)" BROAD [UniProtKB:P29452] synonym: "CASP-1 (mouse)" EXACT [UniProtKB:P29452] synonym: "IL-1BC (mouse)" EXACT [UniProtKB:P29452] synonym: "IL-1 beta-converting enzyme (mouse)" EXACT [UniProtKB:P29452] synonym: "interleukin-1 beta convertase (mouse)" EXACT [UniProtKB:P29452] synonym: "interleukin-1 beta-converting enzyme (mouse)" EXACT [UniProtKB:P29452] xref: UniProtKB:P29452 intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus intersection_of: PR:000002309 ! caspase-1 relationship: has_gene_template MGI:96544 ! Casp1 (mouse) [Term] id: PR:P29466-2 name: caspase-1 isoform beta (human) def: "A caspase-1 isoform 2 that is encoded in the genome of human." [PRO:JAN] comment: Category=organism-sequence. synonym: "hCASP1/iso:beta" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P29466-2 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000002391 ! caspase-1 isoform 2 [Term] id: PR:P29466-1 name: caspase-1 isoform alpha (human) def: "A caspase-1 isoform 1 that is encoded in the genome of human." [PRO:JAN] comment: Category=organism-sequence. synonym: "hCASP1/iso:alpha" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P29466-1 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000002390 ! caspase-1 isoform 1 [Term] id: PR:P29466-3 name: caspase-1 isoform gamma (human) def: "A caspase-1 isoform 3 that is encoded in the genome of human." [PRO:JAN] comment: Category=organism-sequence. synonym: "hCASP1/iso:gamma" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P29466-3 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000002392 ! caspase-1 isoform 3 [Term] id: PR:000002449 name: caspase-1 isoform 1 cleaved 1 def: "A caspase-1 isoform 1 that has been processed by proteolytic cleavage to yield the mature caspase-1 subunit p20." [PMID:8044845, PRO:JAN] comment: Category=modification. synonym: "CASP1/iso:1/Clv:1" EXACT PRO-short-label [PRO:DNx] synonym: "caspase-1 subunit p20" EXACT [] is_a: PR:000002390 ! caspase-1 isoform 1 relationship: output_of GO:0016485 ! protein processing [Term] id: PR:000002309 name: caspase-1 def: "A caspase-1-like protease that is a translation product of the human CASP1 gene or a 1:1 ortholog thereof. The active form of this protein proteolytically cleaves pro-IL-1beta to its mature, active form. The holoenzyme is a homodimer of catalytic domains, each of which contains the cleaved products caspase-1 p20 and p10 subunits." [PMID:8044845, PRO:WCB] comment: Category=gene. synonym: "ICE" EXACT [] synonym: "p45" BROAD [PRO:DNx] synonym: "CASP1" EXACT PRO-short-label [PRO:DNx] synonym: "IL1BC" RELATED Gene-based [] synonym: "CASP-1" EXACT [] synonym: "IL-1BC" EXACT [] synonym: "IL1BCE" RELATED Gene-based [] synonym: "IL-1 beta-converting enzyme" EXACT [] synonym: "interleukin-1 beta convertase" EXACT [] synonym: "interleukin-1 beta-converting enzyme" EXACT [] xref: IUPHARobj:1617 is_a: PR:000002195 ! caspase-1-like protease [Term] id: PR:P29452-1 name: caspase-1 isoform 1 (mouse) def: "A caspase-1 isoform 1 that is encoded in the genome of mouse." [PRO:JAN] comment: Category=organism-sequence. synonym: "mCASP1/iso:1" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P29452-1 intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus intersection_of: PR:000002390 ! caspase-1 isoform 1 [Term] id: PR:000002392 name: caspase-1 isoform 3 def: "A caspase-1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P29466-3 or a 1:1 ortholog thereof." [PMID:15489334, PRO:JAN] comment: Category=sequence. synonym: "CASP1/iso:3" EXACT PRO-short-label [PRO:DNx] synonym: "caspase-1 isoform gamma" EXACT [] is_a: PR:000002309 ! caspase-1 [Term] id: PR:000002393 name: caspase-1 isoform 4 def: "A caspase-1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P29466-4 or a 1:1 ortholog thereof." [PRO:JAN] comment: Category=sequence. synonym: "CASP1/iso:4" EXACT PRO-short-label [PRO:DNx] synonym: "caspase-1 isoform delta" RELATED [] is_a: PR:000002309 ! caspase-1 [Term] id: PR:000002390 name: caspase-1 isoform 1 def: "A caspase-1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P29466-1 or a 1:1 ortholog thereof." [PRO:JAN] comment: Category=sequence. synonym: "CASP1/iso:1" EXACT PRO-short-label [PRO:DNx] synonym: "caspase-1 isoform alpha" EXACT [] is_a: PR:000002309 ! caspase-1 [Term] id: PR:000002391 name: caspase-1 isoform 2 def: "A caspase-1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P29466-2 or a 1:1 ortholog thereof." [PMID:15489334, PRO:JAN] comment: Category=sequence. synonym: "CASP1/iso:2" EXACT PRO-short-label [PRO:DNx] synonym: "caspase-1 isoform beta" EXACT [] is_a: PR:000002309 ! caspase-1 [Term] id: PR:P29466 name: caspase-1 (human) def: "A caspase-1 that is encoded in the genome of human." [PRO:WCB, UniProtKB:P29466] comment: Category=organism-gene. synonym: "CASP1" RELATED Gene-based [UniProtKB:P29466] synonym: "IL1BC" RELATED Gene-based [UniProtKB:P29466] synonym: "IL1BCE" RELATED Gene-based [UniProtKB:P29466] synonym: "hCASP1" EXACT PRO-short-label [PRO:DNx] synonym: "ICE (human)" EXACT [UniProtKB:P29466] synonym: "p45 (human)" BROAD [UniProtKB:P29466] synonym: "CASP-1 (human)" EXACT [UniProtKB:P29466] synonym: "IL-1BC (human)" EXACT [UniProtKB:P29466] synonym: "IL-1 beta-converting enzyme (human)" EXACT [UniProtKB:P29466] synonym: "interleukin-1 beta convertase (human)" EXACT [UniProtKB:P29466] synonym: "interleukin-1 beta-converting enzyme (human)" EXACT [UniProtKB:P29466] xref: Reactome:R-HSA-448692 "PR:P29466 located_in GO:0005829" xref: UniProtKB:P29466 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000002309 ! caspase-1 relationship: has_gene_template HGNC:1499 ! CASP1 (human) [Term] id: PR:000018758 name: caspase-1 proteolytic cleavage product def: "A caspase-1 that has been processed by proteolytic cleavage." [PRO:DNx] comment: Category=modification. synonym: "CASP1/ClvPrd" EXACT PRO-short-label [PRO:DNx] intersection_of: output_of GO:0016485 ! protein processing intersection_of: PR:000002309 ! caspase-1 [Term] id: PR:000002394 name: caspase-1 isoform 5 def: "A caspase-1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P29466-5 or a 1:1 ortholog thereof." [PRO:JAN] comment: Category=sequence. synonym: "CASP1/iso:5" EXACT PRO-short-label [PRO:DNx] synonym: "caspase-1 isoform epsilon" EXACT [] is_a: PR:000002309 ! caspase-1 [Term] id: PR:000002395 name: caspase-1 isoform 6 def: "A caspase-1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P29466-1, 40-404 or a 1:1 ortholog thereof." [PMID:15498465, PRO:JAN] comment: Category=sequence. Note: This isoform might be a possible cloning artifact, as noted in UniProtKB:P29466. synonym: "CASP1/iso:6" EXACT PRO-short-label [PRO:DNx] synonym: "caspase-1 isoform zeta" EXACT [] is_a: PR:000002309 ! caspase-1