[Term]
id: PR:000002998
name: tyrosine-protein kinase Lck
def: "A proto-oncogene SRC-like tyrosine-protein kinase that is a translation product of the human LCK gene or a 1:1 ortholog thereof." [PRO:CNA]
comment: Category=gene.
synonym: "LCK" EXACT PRO-short-label [PRO:DNx]
synonym: "LSK" EXACT []
synonym: "Lsk-t" RELATED Gene-based []
synonym: "p56-LCK" EXACT []
synonym: "proto-oncogene Lck" EXACT []
synonym: "leukocyte C-terminal Src kinase" EXACT []
synonym: "T cell-specific protein-tyrosine kinase" EXACT []
synonym: "proto-oncogene tyrosine-protein kinase lck" EXACT []
synonym: "lymphocyte cell-specific protein-tyrosine kinase" EXACT []
xref: IUPHARobj:2053
is_a: PR:000002997 ! proto-oncogene SRC-like tyrosine-protein kinase

[Term]
id: PR:000048171
name: tyrosine-protein kinase Lck phosphorylated 2 (human)
def: "A tyrosine-protein kinase Lck (human) that has been phosphorylated on the residue at the position equivalent to Tyr-394 of the amino acid sequence represented by UniProtKB:P06239. UniProtKB:P06239, Tyr-394, MOD:00048." [PRO:DNx, Reactome:R-HSA-202308, Reactome:R-HSA-8857940]
comment: Category=organism-modification.
synonym: "hLCK/Phos:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P06239, Tyr-394, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-202308 "PR:000048171 located_in GO:0005829"
xref: Reactome:R-HSA-8857940 "PR:000048171 located_in GO:0005886"
is_a: PR:P06239 ! tyrosine-protein kinase Lck (human)
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000048172
name: tyrosine-protein kinase Lck phosphorylated 3 (human)
def: "A tyrosine-protein kinase Lck (human) that has been phosphorylated on the residue at the position equivalent to Tyr-505 of the amino acid sequence represented by UniProtKB:P06239. UniProtKB:P06239, Tyr-505, MOD:00048." [PRO:DNx, Reactome:R-HSA-202159]
comment: Category=organism-modification.
synonym: "hLCK/Phos:3" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P06239, Tyr-505, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-202159 "PR:000048172 located_in GO:0005886"
is_a: PR:P06239 ! tyrosine-protein kinase Lck (human)
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P06239-3
name: tyrosine-protein kinase Lck isoform h3 (human)
def: "A tyrosine-protein kinase Lck (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P06239-3." [PRO:DNx, UniProtKB:P06239]
comment: Category=organism-sequence.
synonym: "hLCK/iso:h3" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P06239-3
is_a: PR:P06239 ! tyrosine-protein kinase Lck (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000036619
name: tyrosine-protein kinase Lck isoform 1 phosphorylated 1 (human)
def: "A tyrosine-protein kinase Lck isoform 1 phosphorylated 1 in human. UniProtKB:P06239-1, Tyr-394/Tyr-505, MOD:00048." [PMID:9043947, PRO:CL]
comment: Category=organism-modification.
synonym: "hLCK/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P06239-1, Tyr-394/Tyr-505, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000003001 ! tyrosine-protein kinase Lck isoform 1 phosphorylated 1
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine

[Term]
id: PR:000036622
name: tyrosine-protein kinase Lck isoform 1 phosphorylated 2 (human)
def: "A tyrosine-protein kinase Lck isoform 1 phosphorylated 2 in human. UniProtKB:P06239-1, Tyr-394, MOD:00048." [PMID:9043947, PRO:CL]
comment: Category=organism-modification.
synonym: "hLCK/iso:1/Phos:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P06239-1, Tyr-394, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000003034 ! tyrosine-protein kinase Lck isoform 1 phosphorylated 2
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine

[Term]
id: PR:P06239-1
name: tyrosine-protein kinase Lck isoform Long (human)
def: "A tyrosine-protein kinase Lck isoform 1 that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "hLCK/iso:Long" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P06239-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000002999 ! tyrosine-protein kinase Lck isoform 1

[Term]
id: PR:P06239-2
name: tyrosine-protein kinase Lck isoform Short (human)
def: "A tyrosine-protein kinase Lck (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P06239-2." [PRO:DNx, UniProtKB:P06239]
comment: Category=organism-sequence.
synonym: "hLCK/iso:Short" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P06239-2
is_a: PR:P06239 ! tyrosine-protein kinase Lck (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P06239
name: tyrosine-protein kinase Lck (human)
def: "A tyrosine-protein kinase Lck that is encoded in the genome of human." [PRO:DNx]
comment: Category=organism-gene.
synonym: "LCK" RELATED Gene-based [UniProtKB:P06239]
synonym: "hLCK" EXACT PRO-short-label [PRO:DNx]
synonym: "LSK (human)" EXACT [UniProtKB:P06239]
synonym: "p56-LCK (human)" EXACT [UniProtKB:P06239]
synonym: "protein YT16 (human)" EXACT [UniProtKB:P06239]
synonym: "proto-oncogene Lck (human)" EXACT [UniProtKB:P06239]
synonym: "leukocyte C-terminal Src kinase (human)" EXACT [UniProtKB:P06239]
synonym: "T cell-specific protein-tyrosine kinase (human)" EXACT [UniProtKB:P06239]
synonym: "lymphocyte cell-specific protein-tyrosine kinase (human)" EXACT [UniProtKB:P06239]
xref: Reactome:R-HSA-167609 "PR:P06239 located_in GO:0005829"
xref: DTO:03100266
xref: UniProtKB:P06239
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000002998 ! tyrosine-protein kinase Lck
relationship: has_gene_template HGNC:6524 ! LCK (human)