[Term]
id: PR:P70347-4
name: TRAF family member-associated NF-kappa-B activator isoform m4 (mouse)
def: "A TRAF family member-associated NF-kappa-B activator (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P70347-4." [PRO:DNx, UniProtKB:P70347]
comment: Category=organism-sequence.
synonym: "mTANK/iso:m4" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P70347-4
is_a: PR:P70347 ! TRAF family member-associated NF-kappa-B activator (mouse)
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:P70347
name: TRAF family member-associated NF-kappa-B activator (mouse)
def: "A TRAF family member-associated NF-kappa-B activator that is encoded in the genome of mouse." [OMA:P70347, PRO:CNA]
comment: Category=organism-gene. Requested by=TLR.
synonym: "Tank" RELATED Gene-based [UniProtKB:P70347]
synonym: "Itraf" RELATED Gene-based [UniProtKB:P70347]
synonym: "mTANK" EXACT PRO-short-label [PRO:DNx]
synonym: "I-TRAF (mouse)" EXACT []
synonym: "TRAF-interacting protein (mouse)" BROAD [PRO:DNx]
xref: UniProtKB:P70347
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000003146 ! TRAF family member-associated NF-kappa-B activator
relationship: has_gene_template MGI:107676 ! Tank (mouse)

[Term]
id: PR:000003193
name: TRAF family member-associated NF-kappa-B activator isoform 1
def: "A TRAF family member-associated NF-kappa-B activator that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P70347-1 or a 1:1 ortholog thereof." [PRO:CNA]
comment: Category=sequence.
synonym: "tank beta" EXACT []
synonym: "TANK/iso:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000003146 ! TRAF family member-associated NF-kappa-B activator

[Term]
id: PR:000003146
name: TRAF family member-associated NF-kappa-B activator
def: "A protein that is a translation product of the human TANK gene or a 1:1 ortholog thereof." [PRO:CNA]
comment: Category=gene.
synonym: "TANK" EXACT PRO-short-label [PRO:DNx]
synonym: "ITRAF" RELATED Gene-based []
synonym: "TRAF2" RELATED Gene-based []
synonym: "I-TRAF" EXACT []
synonym: "TRAF-interacting protein" BROAD [PRO:DNx]
is_a: PR:000000001 ! protein

[Term]
id: PR:000036091
name: TRAF family member-associated NF-kappa-B activator isoform 1 K63-polyubiquitinated form (mouse)
def: "A TRAF family member-associated NF-kappa-B activator isoform 1 K63-polyubiquitinated form in mouse. UniProtKB:P70347-1, PR:000044772." [TLR:AMM]
comment: Category=organism-modification. Requested by=TLR.
synonym: "mTANK/iso:1/K63polyUbiq+" EXACT PRO-short-label [PRO:DNx]
synonym: "TANK k63 ubiquitinated (mouse)" EXACT []
synonym: "UniProtKB:P70347-1, PR:000044772" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000003300 ! TRAF family member-associated NF-kappa-B activator isoform 1 K63-polyubiquitinated form
relationship: has_part PR:000044772 ! K63-polyubiquitinylated lysine

[Term]
id: PR:P70347-3
name: TRAF family member-associated NF-kappa-B activator isoform m3 (mouse)
def: "A TRAF family member-associated NF-kappa-B activator (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P70347-3." [PRO:DNx, UniProtKB:P70347]
comment: Category=organism-sequence.
synonym: "mTANK/iso:m3" EXACT PRO-short-label [PRO:DNx]
synonym: "TRAF family member-associated NF-kappa-B activator isoform Gamma (mouse)" EXACT [UniProtKB:P70347]
xref: UniProtKB:P70347-3
is_a: PR:P70347 ! TRAF family member-associated NF-kappa-B activator (mouse)
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:000003196
name: TRAF family member-associated NF-kappa-B activator isoform 1 phosphorylated and ubiquitinated 1
def: "A TRAF family member-associated NF-kappa-B activator isoform 1 phosphorylated and ubiquitinated form that has been phosphorylated by TBK1-IKKE upon lipopolysaccharide stimulation and is also subject to lipopolysaccharide- and TBK1-IKKE-mediated Lys-63-linked polyubiquitination, a mechanism that does not require TBK1-IKKE kinase activity." [PMID:17823124, TLR:AMM]
comment: Category=modification. Requested by=TLR.
synonym: "TANK/iso:1/PhosUbiq:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000003195 ! TRAF family member-associated NF-kappa-B activator isoform 1 phosphorylated and ubiquitinated form

[Term]
id: PR:000003195
name: TRAF family member-associated NF-kappa-B activator isoform 1 phosphorylated and ubiquitinated form
def: "A TRAF family member-associated NF-kappa-B activator isoform 1 that includes at least one phosphorylated residue and at least one ubiquitinated lysine." [PRO:CNA]
comment: Category=modification.
synonym: "TANK/iso:1/PhosUbiq+" EXACT PRO-short-label [PRO:DNx]
intersection_of: has_part MOD:00696 ! phosphorylated residue
intersection_of: has_part MOD:01148 ! ubiquitinylated lysine
intersection_of: PR:000003193 ! TRAF family member-associated NF-kappa-B activator isoform 1

[Term]
id: PR:P70347-2
name: TRAF family member-associated NF-kappa-B activator isoform m2 (mouse)
def: "A TRAF family member-associated NF-kappa-B activator (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P70347-2." [PRO:DNx, UniProtKB:P70347]
comment: Category=organism-sequence.
synonym: "mTANK/iso:m2" EXACT PRO-short-label [PRO:DNx]
synonym: "TRAF family member-associated NF-kappa-B activator isoform Alpha (mouse)" EXACT [UniProtKB:P70347]
xref: UniProtKB:P70347-2
is_a: PR:P70347 ! TRAF family member-associated NF-kappa-B activator (mouse)
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:Q92844-2
name: TRAF family member-associated NF-kappa-B activator isoform Short (human)
def: "A TRAF family member-associated NF-kappa-B activator (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q92844-2." [PRO:DNx, UniProtKB:Q92844]
comment: Category=organism-sequence.
synonym: "hTANK/iso:Short" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q92844-2
is_a: PR:Q92844 ! TRAF family member-associated NF-kappa-B activator (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000049397
name: TRAF family member-associated NF-kappa-B activator ubiquitinated form (human)
def: "A TRAF family member-associated NF-kappa-B activator (human) that includes at least one ubiquitinated lysine. UniProtKB:Q92844, MOD:01148." [PRO:DNx, Reactome:R-HSA-5362480]
comment: Category=organism-modification.
synonym: "hTANK/UbiqLys+" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q92844, MOD:01148" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-5362480 "PR:000049397 located_in GO:0005829"
intersection_of: has_part MOD:01148 ! ubiquitinylated lysine
intersection_of: PR:Q92844 ! TRAF family member-associated NF-kappa-B activator (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000003300
name: TRAF family member-associated NF-kappa-B activator isoform 1 K63-polyubiquitinated form
def: "A TRAF family member-associated NF-kappa-B activator isoform 1 that has K63-linked polyubiquitin. Example: UniProtKB:Q92844-1, PR:000044772." [PRO:CNA, TLR:AMM]
comment: Category=modification. Requested by=TLR.
synonym: "TANK k63 ubiquitinated" EXACT []
synonym: "TANK/iso:1/K63polyUbiq+" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000003193 ! TRAF family member-associated NF-kappa-B activator isoform 1
relationship: has_part PR:000044772 ! K63-polyubiquitinylated lysine

[Term]
id: PR:P70347-1
name: TRAF family member-associated NF-kappa-B activator isoform 1 (mouse)
def: "A TRAF family member-associated NF-kappa-B activator isoform 1 that is encoded in the genome of mouse." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "mTANK/iso:1" EXACT PRO-short-label [PRO:DNx]
synonym: "TRAF family member-associated NF-kappa-B activator isoform Beta (mouse)" EXACT [UniProtKB:P70347]
xref: UniProtKB:P70347-1
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000003193 ! TRAF family member-associated NF-kappa-B activator isoform 1

[Term]
id: PR:Q92844-1
name: TRAF family member-associated NF-kappa-B activator isoform Long (human)
def: "A TRAF family member-associated NF-kappa-B activator isoform 1 that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "hTANK/iso:Long" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q92844-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000003193 ! TRAF family member-associated NF-kappa-B activator isoform 1

[Term]
id: PR:Q92844
name: TRAF family member-associated NF-kappa-B activator (human)
def: "A TRAF family member-associated NF-kappa-B activator that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q92844]
comment: Category=organism-gene.
synonym: "TANK" RELATED Gene-based [UniProtKB:Q92844]
synonym: "ITRAF" RELATED Gene-based [UniProtKB:Q92844]
synonym: "TRAF2" RELATED Gene-based [UniProtKB:Q92844]
synonym: "hTANK" EXACT PRO-short-label [PRO:DNx]
synonym: "I-TRAF (human)" EXACT [UniProtKB:Q92844]
synonym: "TRAF-interacting protein (human)" BROAD [PRO:DAN, UniProtKB:Q92844]
xref: Reactome:R-HSA-933407 "PR:Q92844 located_in GO:0005829"
xref: UniProtKB:Q92844
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000003146 ! TRAF family member-associated NF-kappa-B activator
relationship: has_gene_template HGNC:11562 ! TANK (human)

[Term]
id: PR:Q92844-3
name: TRAF family member-associated NF-kappa-B activator isoform h3 (human)
def: "A TRAF family member-associated NF-kappa-B activator (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q92844-3." [PRO:DNx, UniProtKB:Q92844]
comment: Category=organism-sequence.
synonym: "hTANK/iso:h3" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q92844-3
is_a: PR:Q92844 ! TRAF family member-associated NF-kappa-B activator (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens