[Term] id: PR:000003158 name: mitogen-activated protein kinase kinase kinase 7 def: "A protein that is a translation product of the human MAP3K7 gene or a 1:1 ortholog thereof." [PRO:CNA] comment: Category=gene. synonym: "TAK1" RELATED Gene-based [] synonym: "MAP3K7" EXACT PRO-short-label [PRO:DNx] synonym: "TGF-beta-activated kinase 1" EXACT [] synonym: "transforming growth factor-beta-activated kinase 1" EXACT [] xref: IUPHARobj:2082 xref: PIRSF:PIRSF038168 is_a: PR:000000001 ! protein [Term] id: PR:O43318-1 name: mitogen-activated protein kinase kinase kinase 7 isoform h1B (human) def: "A mitogen-activated protein kinase kinase kinase 7 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O43318-1." [PRO:DNx, UniProtKB:O43318] comment: Category=organism-sequence. synonym: "hMAP3K7/iso:h1B" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:O43318-1 is_a: PR:O43318 ! mitogen-activated protein kinase kinase kinase 7 (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:O43318-2 name: mitogen-activated protein kinase kinase kinase 7 isoform 1A (human) def: "A mitogen-activated protein kinase kinase kinase 7 isoform 1 that is encoded in the genome of human." [PRO:DNx, UniProtKB:O43318] comment: Category=organism-sequence. synonym: "hMAP3K7/iso:1A" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:O43318-2 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000003159 ! mitogen-activated protein kinase kinase kinase 7 isoform 1 [Term] id: PR:O43318-3 name: mitogen-activated protein kinase kinase kinase 7 isoform h1C (human) def: "A mitogen-activated protein kinase kinase kinase 7 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O43318-3." [PRO:DNx, UniProtKB:O43318] comment: Category=organism-sequence. synonym: "hMAP3K7/iso:h1C" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:O43318-3 is_a: PR:O43318 ! mitogen-activated protein kinase kinase kinase 7 (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:O43318-4 name: mitogen-activated protein kinase kinase kinase 7 isoform h1D (human) def: "A mitogen-activated protein kinase kinase kinase 7 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O43318-4." [PRO:DNx, UniProtKB:O43318] comment: Category=organism-sequence. synonym: "hMAP3K7/iso:h1D" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:O43318-4 is_a: PR:O43318 ! mitogen-activated protein kinase kinase kinase 7 (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000048307 name: mitogen-activated protein kinase kinase kinase 7 phosphorylated 2 (human) def: "A mitogen-activated protein kinase kinase kinase 7 (human) that has been phosphorylated on the residue at the position equivalent to Thr-187 of the amino acid sequence represented by UniProtKB:O43318. UniProtKB:O43318, Thr-187, MOD:00047." [PRO:DNx, Reactome:R-HSA-1168568, Reactome:R-HSA-206014] comment: Category=organism-modification. synonym: "hMAP3K7/Phos:2" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:O43318, Thr-187, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx] xref: Reactome:R-HSA-206014 "PR:000048307 located_in GO:0005829" xref: Reactome:R-HSA-1168568 "PR:000048307 located_in GO:0005886" is_a: PR:O43318 ! mitogen-activated protein kinase kinase kinase 7 (human) relationship: has_part MOD:00047 ! O-phospho-L-threonine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000048309 name: mitogen-activated protein kinase kinase kinase 7 ubiquitinated 1 (human) def: "A mitogen-activated protein kinase kinase kinase 7 (human) that has been post-translationally modified to include ubiquitinated lysine at positions 34 and 158 of the amino acid sequence represented by UniProtKB:O43318. UniProtKB:O43318, Lys-34/Lys-158, MOD:01148." [PRO:DNx, Reactome:R-HSA-5607643] comment: Category=organism-modification. synonym: "hMAP3K7/Ubiq:1" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:O43318, Lys-34/Lys-158, MOD:01148" EXACT PRO-proteoform-std [PRO:DNx] xref: Reactome:R-HSA-5607643 "PR:000048309 located_in GO:0005829" is_a: PR:O43318 ! mitogen-activated protein kinase kinase kinase 7 (human) relationship: has_part MOD:01148 ! ubiquitinylated lysine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000048308 name: mitogen-activated protein kinase kinase kinase 7 phosphorylated form (human) def: "A mitogen-activated protein kinase kinase kinase 7 (human) that includes at least one phosphorylated residue. UniProtKB:O43318, MOD:00696." [PRO:DNx, Reactome:R-HSA-168163] comment: Category=organism-modification. synonym: "hMAP3K7/PhosRes+" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:O43318, MOD:00696" EXACT PRO-proteoform-std [PRO:DNx] xref: Reactome:R-HSA-168163 "PR:000048308 located_in GO:0005829" intersection_of: has_part MOD:00696 ! phosphorylated residue intersection_of: PR:O43318 ! mitogen-activated protein kinase kinase kinase 7 (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000035736 name: mitogen-activated protein kinase kinase kinase 7 phosphorylated 1 (human) def: "A mitogen-activated protein kinase kinase kinase 7 phosphorylated 1 in human. UniProtKB:O43318, Thr-184/Thr-187, MOD:00047." [PRO:DNx, UniProtKB:O43318] comment: Category=organism-modification. synonym: "hMAP3K7/Phos:1" EXACT PRO-short-label [PRO:DNx] synonym: "p-T184,187-TAK1 (human)" EXACT [Reactome:R-HSA-202527, Reactome:R-HSA-450332] synonym: "UniProtKB:O43318, Thr-184/Thr-187, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx] xref: Reactome:R-HSA-202527 "PR:000035736 located_in GO:0005829" xref: Reactome:R-HSA-450332 "PR:000035736 located_in GO:0010008" intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000035735 ! mitogen-activated protein kinase kinase kinase 7 phosphorylated 1 relationship: has_part MOD:00047 ! O-phospho-L-threonine [Term] id: PR:000048310 name: mitogen-activated protein kinase kinase kinase 7 ubiquitinated form (human) def: "A mitogen-activated protein kinase kinase kinase 7 (human) that includes at least one ubiquitinated lysine. UniProtKB:O43318, MOD:01148." [PRO:DNx, Reactome:R-HSA-6782968] comment: Category=organism-modification. synonym: "hMAP3K7/UbiqLys+" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:O43318, MOD:01148" EXACT PRO-proteoform-std [PRO:DNx] xref: Reactome:R-HSA-6782968 "PR:000048310 located_in GO:0005829" intersection_of: has_part MOD:01148 ! ubiquitinylated lysine intersection_of: PR:O43318 ! mitogen-activated protein kinase kinase kinase 7 (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:O43318 name: mitogen-activated protein kinase kinase kinase 7 (human) def: "A mitogen-activated protein kinase kinase kinase 7 that is encoded in the genome of human." [PRO:DNx, UniProtKB:O43318] comment: Category=organism-gene. synonym: "TAK1" RELATED Gene-based [UniProtKB:O43318] synonym: "MAP3K7" RELATED Gene-based [UniProtKB:O43318] synonym: "hMAP3K7" EXACT PRO-short-label [PRO:DNx] synonym: "TGF-beta-activated kinase 1 (human)" EXACT [UniProtKB:O43318] synonym: "transforming growth factor-beta-activated kinase 1 (human)" EXACT [UniProtKB:O43318] xref: Reactome:R-HSA-168156 "PR:O43318 located_in GO:0005829" xref: Reactome:R-HSA-450315 "PR:O43318 located_in GO:0010008" xref: Reactome:R-HSA-9012677 "PR:O43318 located_in GO:0005886" xref: DTO:03100289 xref: UniProtKB:O43318 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000003158 ! mitogen-activated protein kinase kinase kinase 7 relationship: has_gene_template HGNC:6859 ! MAP3K7 (human)