[Term]
id: PR:P02458
name: collagen alpha-1(II) chain (human)
def: "A collagen type II alpha chain that is encoded in the genome of human." [PRO:CNA, UniProtKB:P02458]
comment: Category=organism-gene.
synonym: "COL2A1" RELATED Gene-based [UniProtKB:P02458]
synonym: "hCOL2A1" EXACT PRO-short-label [PRO:DNx]
synonym: "alpha-1 type II collagen (human)" EXACT [UniProtKB:P02458]
xref: UniProtKB:P02458
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000003266 ! collagen type II alpha chain
relationship: has_gene_template HGNC:2200 ! COL2A1 (human)

[Term]
id: PR:P02458-3
name: collagen alpha-1(II) chain isoform h3 (human)
def: "A collagen alpha-1(II) chain (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P02458-3." [PRO:DNx, UniProtKB:P02458]
comment: Category=organism-sequence.
synonym: "hCOL2A1/iso:h3" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P02458-3
is_a: PR:P02458 ! collagen alpha-1(II) chain (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P02458-2
name: collagen alpha-1(II) chain isoform 2 (human)
def: "A collagen type II alpha chain isoform 2 that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "hCOL2A1/iso:2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P02458-2
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000003365 ! collagen type II alpha chain isoform 2

[Term]
id: PR:000003266
name: collagen type II alpha chain
def: "A collagen alpha chain that is a translation product of the human COL2A1 gene or a 1:1 ortholog thereof." [PRO:CNA]
comment: Category=gene.
synonym: "COL2A1" EXACT PRO-short-label [PRO:DNx]
synonym: "alpha-1 type II collagen" EXACT []
is_a: PR:000003262 ! collagen alpha chain

[Term]
id: PR:000046886
name: collagen alpha-1(II) chain, signal peptide removed 5-hydroxy-lysine and 4-hydroxy-proline form (human)
def: "A collagen alpha-1(II) chain (human) that has had the signal peptide removed and that includes at least one 5-hydroxy-lysine and at least one 4-hydroxy-proline. UniProtKB:P02458, 26-1487, MOD:00037|MOD:00039." [PRO:DNx, Reactome:R-HSA-2022967, Reactome:R-HSA-2268702]
comment: Category=organism-modification.
synonym: "hCOL2A1/SigPep-/5hL4hP+" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P02458, 26-1487, MOD:00037|MOD:00039" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-2022967 "PR:000046886 located_in GO:0005788"
xref: Reactome:R-HSA-2268702 "PR:000046886 located_in GO:0005576"
intersection_of: has_part MOD:00037 ! 5-hydroxy-L-lysine
intersection_of: has_part MOD:00039 ! 4-hydroxy-L-proline
intersection_of: PR:P02458 ! collagen alpha-1(II) chain (human)
intersection_of: lacks_part SO:0000418 ! signal_peptide
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P02458-1
name: collagen alpha-1(II) chain isoform 1 (human)
def: "A collagen type II alpha chain isoform 1 that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "hCOL2A1/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P02458-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000003362 ! collagen type II alpha chain isoform 1

[Term]
id: PR:000046884
name: collagen alpha-1(II) chain, signal peptide removed 5-hydroxy-lysine form (human)
def: "A collagen alpha-1(II) chain (human) that has had the signal peptide removed and that includes at least one 5-hydroxy-lysine. UniProtKB:P02458, 26-1487, MOD:00037." [PRO:DNx, Reactome:R-HSA-2022466, Reactome:R-HSA-2268657]
comment: Category=organism-modification.
synonym: "hCOL2A1/SigPep-/5HyLys+" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P02458, 26-1487, MOD:00037" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-2022466 "PR:000046884 located_in GO:0005788"
xref: Reactome:R-HSA-2268657 "PR:000046884 located_in GO:0005576"
intersection_of: has_part MOD:00037 ! 5-hydroxy-L-lysine
intersection_of: PR:P02458 ! collagen alpha-1(II) chain (human)
intersection_of: lacks_part SO:0000418 ! signal_peptide
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000046885
name: collagen alpha-1(II) chain, signal peptide removed 5-hydroxy-lysine, 3-hydroxy-proline and 4-hydroxy-proline form (human)
def: "A collagen alpha-1(II) chain (human) that has had the signal peptide removed and that includes at least one 5-hydroxy-lysine, at least one 3-hydroxy-proline and at least one 4-hydroxy-proline. UniProtKB:P02458, 26-1487, MOD:00037|MOD:00038|MOD:00039." [PRO:DNx, Reactome:R-HSA-2022968, Reactome:R-HSA-2268640]
comment: Category=organism-modification.
synonym: "hCOL2A1/SigPep-/5hL3hP4hP+" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P02458, 26-1487, MOD:00037|MOD:00038|MOD:00039" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-2022968 "PR:000046885 located_in GO:0005788"
xref: Reactome:R-HSA-2268640 "PR:000046885 located_in GO:0005576"
intersection_of: has_part MOD:00037 ! 5-hydroxy-L-lysine
intersection_of: has_part MOD:00038 ! 3-hydroxy-L-proline
intersection_of: has_part MOD:00039 ! 4-hydroxy-L-proline
intersection_of: PR:P02458 ! collagen alpha-1(II) chain (human)
intersection_of: lacks_part SO:0000418 ! signal_peptide
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000046882
name: collagen alpha-1(II) chain, signal peptide removed 3-hydroxy-proline and 4-hydroxy-proline form (human)
def: "A collagen alpha-1(II) chain (human) that has had the signal peptide removed and that includes at least one 3-hydroxy-proline and at least one 4-hydroxy-proline. UniProtKB:P02458, 26-1487, MOD:00038|MOD:00039." [PRO:DNx, Reactome:R-HSA-2022425, Reactome:R-HSA-2268684]
comment: Category=organism-modification.
synonym: "hCOL2A1/SigPep-/3hP4hP+" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P02458, 26-1487, MOD:00038|MOD:00039" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-2022425 "PR:000046882 located_in GO:0005788"
xref: Reactome:R-HSA-2268684 "PR:000046882 located_in GO:0005576"
intersection_of: has_part MOD:00038 ! 3-hydroxy-L-proline
intersection_of: has_part MOD:00039 ! 4-hydroxy-L-proline
intersection_of: PR:P02458 ! collagen alpha-1(II) chain (human)
intersection_of: lacks_part SO:0000418 ! signal_peptide
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000046883
name: collagen alpha-1(II) chain, signal peptide removed 4-hydroxy-proline form (human)
def: "A collagen alpha-1(II) chain (human) that has had the signal peptide removed and that includes at least one 4-hydroxy-proline. UniProtKB:P02458, 26-1487, MOD:00039." [PRO:DNx, Reactome:R-HSA-2022096, Reactome:R-HSA-2268699]
comment: Category=organism-modification.
synonym: "hCOL2A1/SigPep-/4HyPro+" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P02458, 26-1487, MOD:00039" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-2022096 "PR:000046883 located_in GO:0005788"
xref: Reactome:R-HSA-2268699 "PR:000046883 located_in GO:0005576"
intersection_of: has_part MOD:00039 ! 4-hydroxy-L-proline
intersection_of: PR:P02458 ! collagen alpha-1(II) chain (human)
intersection_of: lacks_part SO:0000418 ! signal_peptide
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000046881
name: collagen alpha-1(II) chain, signal peptide removed form (human)
def: "A collagen alpha-1(II) chain (human) that has had the signal peptide removed. UniProtKB:P02458, 26-1487." [PRO:DNx, Reactome:R-HSA-1980183, Reactome:R-HSA-2268655]
comment: Category=organism-modification.
synonym: "hCOL2A1/SigPep-" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P02458, 26-1487" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-1980183 "PR:000046881 located_in GO:0005788"
xref: Reactome:R-HSA-2268655 "PR:000046881 located_in GO:0005576"
intersection_of: PR:P02458 ! collagen alpha-1(II) chain (human)
intersection_of: lacks_part SO:0000418 ! signal_peptide
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens