[Term]
id: PR:000018800
name: collagen type II alpha chain proteolytic cleavage product
def: "A collagen type II alpha chain that has been processed by proteolytic cleavage." [PRO:DNx]
comment: Category=modification.
synonym: "COL2A1/ClvPrd" EXACT PRO-short-label [PRO:DNx]
intersection_of: output_of GO:0016485 ! protein processing
intersection_of: PR:000003266 ! collagen type II alpha chain

[Term]
id: PR:000003368
name: collagen type II alpha chain isoform 2 cleaved 1
def: "A collagen type II alpha chain isoform 2, signal peptide removed form that has been processed by subsequent removal of the N-terminal propeptide and the C-terminal chondrocalcin sequence, yielding the mature protein. Example: UniProtKB:P02458-2, 182-1241." [PRO:CNA]
comment: Category=modification.
synonym: "COL2A1/iso:2/Clv:1" EXACT PRO-short-label [PRO:DNx]
synonym: "collagen alpha-1(II) chain" EXACT []
synonym: "collagen alpha-1(II) chain mature" EXACT []
is_a: PR:000021924 ! collagen type II alpha chain isoform 2, signal peptide removed form
relationship: output_of GO:0016485 ! protein processing
relationship: lacks_part SO:0001062 ! propeptide

[Term]
id: PR:P05539
name: collagen alpha-1(II) chain (rat)
def: "A collagen type II alpha chain that is encoded in the genome of rat." [OMA:P05539, PANTHER:PTHR24023:SF126, PRO:DNx]
comment: Category=organism-gene.
synonym: "Col2a1" RELATED Gene-based [UniProtKB:P05539]
synonym: "rCOL2A1" EXACT PRO-short-label [PRO:DNx]
synonym: "alpha-1 type II collagen (rat)" EXACT [UniProtKB:P05539]
xref: UniProtKB:P05539
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000003266 ! collagen type II alpha chain
relationship: has_gene_template RGD:2375 ! Col2a1 (rat)

[Term]
id: PR:P02458-1
name: collagen alpha-1(II) chain isoform 1 (human)
def: "A collagen type II alpha chain isoform 1 that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "hCOL2A1/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P02458-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000003362 ! collagen type II alpha chain isoform 1

[Term]
id: PR:P02458-3
name: collagen alpha-1(II) chain isoform h3 (human)
def: "A collagen alpha-1(II) chain (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P02458-3." [PRO:DNx, UniProtKB:P02458]
comment: Category=organism-sequence.
synonym: "hCOL2A1/iso:h3" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P02458-3
is_a: PR:P02458 ! collagen alpha-1(II) chain (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P02458-2
name: collagen alpha-1(II) chain isoform 2 (human)
def: "A collagen type II alpha chain isoform 2 that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "hCOL2A1/iso:2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P02458-2
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000003365 ! collagen type II alpha chain isoform 2

[Term]
id: PR:000003362
name: collagen type II alpha chain isoform 1
def: "A collagen type II alpha chain that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P02458-1 or a 1:1 ortholog thereof." [PRO:CNA]
comment: Category=sequence.
synonym: "COL2A1/iso:1" EXACT PRO-short-label [PRO:DNx]
synonym: "collagen alpha-1(II) chain isoform 1" EXACT []
is_a: PR:000003266 ! collagen type II alpha chain

[Term]
id: PR:000003266
name: collagen type II alpha chain
def: "A collagen alpha chain that is a translation product of the human COL2A1 gene or a 1:1 ortholog thereof." [PRO:CNA]
comment: Category=gene.
synonym: "COL2A1" EXACT PRO-short-label [PRO:DNx]
synonym: "alpha-1 type II collagen" EXACT []
is_a: PR:000003262 ! collagen alpha chain

[Term]
id: PR:000003365
name: collagen type II alpha chain isoform 2
def: "A collagen type II alpha chain that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P02458-2 or a 1:1 ortholog thereof." [PRO:CNA]
comment: Category=sequence.
synonym: "COL2A1/iso:2" EXACT PRO-short-label [PRO:DNx]
synonym: "collagen alpha-1(II) chain isoform 2" EXACT []
is_a: PR:000003266 ! collagen type II alpha chain

[Term]
id: PR:000003367
name: chondrocalcin
def: "A collagen type II alpha chain isoform 2 that is the C-terminal region after proteolytic cleavage. Example: UniProtKB:P02458-2, 1242-1487." [PMID:3800925, PRO:CNA]
comment: Category=modification.
synonym: "COL2A1/iso:2/Clv:2" EXACT PRO-short-label [PRO:DAN]
is_a: PR:000003365 ! collagen type II alpha chain isoform 2
relationship: output_of GO:0016485 ! protein processing

[Term]
id: PR:000021924
name: collagen type II alpha chain isoform 2, signal peptide removed form
def: "A collagen type II alpha chain isoform 2 that has had the signal peptide removed." [PRO:DNx]
comment: Category=modification.
synonym: "COL2A1/iso:2/SigPep-" EXACT PRO-short-label [PRO:DNx]
intersection_of: PR:000003365 ! collagen type II alpha chain isoform 2
intersection_of: lacks_part SO:0000418 ! signal_peptide

[Term]
id: PR:P02458
name: collagen alpha-1(II) chain (human)
def: "A collagen type II alpha chain that is encoded in the genome of human." [PRO:CNA, UniProtKB:P02458]
comment: Category=organism-gene.
synonym: "COL2A1" RELATED Gene-based [UniProtKB:P02458]
synonym: "hCOL2A1" EXACT PRO-short-label [PRO:DNx]
synonym: "alpha-1 type II collagen (human)" EXACT [UniProtKB:P02458]
xref: UniProtKB:P02458
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000003266 ! collagen type II alpha chain
relationship: has_gene_template HGNC:2200 ! COL2A1 (human)

[Term]
id: PR:P28481-7
name: collagen alpha-1(II) chain isoform m7 (mouse)
def: "A collagen alpha-1(II) chain (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P28481-7." [PRO:DNx, UniProtKB:P28481]
comment: Category=organism-sequence.
synonym: "mCOL2A1/iso:m7" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P28481-7
is_a: PR:P28481 ! collagen alpha-1(II) chain (mouse)
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:P28481-6
name: collagen alpha-1(II) chain isoform m6 (mouse)
def: "A collagen alpha-1(II) chain (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P28481-6." [PRO:DNx, UniProtKB:P28481]
comment: Category=organism-sequence.
synonym: "mCOL2A1/iso:m6" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P28481-6
is_a: PR:P28481 ! collagen alpha-1(II) chain (mouse)
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:P28481-5
name: collagen alpha-1(II) chain isoform m5 (mouse)
def: "A collagen alpha-1(II) chain (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P28481-5." [PRO:DNx, UniProtKB:P28481]
comment: Category=organism-sequence.
synonym: "mCOL2A1/iso:m5" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P28481-5
is_a: PR:P28481 ! collagen alpha-1(II) chain (mouse)
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:P28481-4
name: collagen alpha-1(II) chain isoform m4 (mouse)
def: "A collagen alpha-1(II) chain (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P28481-4." [PRO:DNx, UniProtKB:P28481]
comment: Category=organism-sequence.
synonym: "mCOL2A1/iso:m4" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P28481-4
is_a: PR:P28481 ! collagen alpha-1(II) chain (mouse)
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:P28481-3
name: collagen alpha-1(II) chain isoform m1 (mouse)
def: "A collagen alpha-1(II) chain (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P28481-3." [PRO:DNx, UniProtKB:P28481]
comment: Category=organism-sequence.
synonym: "mCOL2A1/iso:m1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P28481-3
is_a: PR:P28481 ! collagen alpha-1(II) chain (mouse)
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:P28481-2
name: collagen alpha-1(II) chain isoform m3 (mouse)
def: "A collagen alpha-1(II) chain (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P28481-2." [PRO:DNx, UniProtKB:P28481]
comment: Category=organism-sequence.
synonym: "mCOL2A1/iso:m3" EXACT PRO-short-label [PRO:DNx]
synonym: "collagen alpha-1(II) chain isoform Short (mouse)" EXACT [UniProtKB:P28481]
xref: UniProtKB:P28481-2
is_a: PR:P28481 ! collagen alpha-1(II) chain (mouse)
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:P28481-1
name: collagen alpha-1(II) chain isoform m2 (mouse)
def: "A collagen alpha-1(II) chain (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P28481-1." [PRO:DNx, UniProtKB:P28481]
comment: Category=organism-sequence.
synonym: "mCOL2A1/iso:m2" EXACT PRO-short-label [PRO:DNx]
synonym: "collagen alpha-1(II) chain isoform Long (mouse)" EXACT [UniProtKB:P28481]
xref: UniProtKB:P28481-1
is_a: PR:P28481 ! collagen alpha-1(II) chain (mouse)
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:P28481
name: collagen alpha-1(II) chain (mouse)
def: "A collagen type II alpha chain that is encoded in the genome of mouse." [OMA:P28481, PRO:DNx]
comment: Category=organism-gene.
synonym: "Col2a1" RELATED Gene-based [UniProtKB:P28481]
synonym: "mCOL2A1" EXACT PRO-short-label [PRO:DNx]
synonym: "alpha-1 type II collagen (mouse)" EXACT [UniProtKB:P28481]
xref: UniProtKB:P28481
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000003266 ! collagen type II alpha chain
relationship: has_gene_template MGI:88452 ! Col2a1 (mouse)

[Term]
id: PR:000046886
name: collagen alpha-1(II) chain, signal peptide removed 5-hydroxy-lysine and 4-hydroxy-proline form (human)
def: "A collagen alpha-1(II) chain (human) that has had the signal peptide removed and that includes at least one 5-hydroxy-lysine and at least one 4-hydroxy-proline. UniProtKB:P02458, 26-1487, MOD:00037|MOD:00039." [PRO:DNx, Reactome:R-HSA-2022967, Reactome:R-HSA-2268702]
comment: Category=organism-modification.
synonym: "hCOL2A1/SigPep-/5hL4hP+" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P02458, 26-1487, MOD:00037|MOD:00039" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-2022967 "PR:000046886 located_in GO:0005788"
xref: Reactome:R-HSA-2268702 "PR:000046886 located_in GO:0005576"
intersection_of: has_part MOD:00037 ! 5-hydroxy-L-lysine
intersection_of: has_part MOD:00039 ! 4-hydroxy-L-proline
intersection_of: PR:P02458 ! collagen alpha-1(II) chain (human)
intersection_of: lacks_part SO:0000418 ! signal_peptide
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000046884
name: collagen alpha-1(II) chain, signal peptide removed 5-hydroxy-lysine form (human)
def: "A collagen alpha-1(II) chain (human) that has had the signal peptide removed and that includes at least one 5-hydroxy-lysine. UniProtKB:P02458, 26-1487, MOD:00037." [PRO:DNx, Reactome:R-HSA-2022466, Reactome:R-HSA-2268657]
comment: Category=organism-modification.
synonym: "hCOL2A1/SigPep-/5HyLys+" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P02458, 26-1487, MOD:00037" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-2022466 "PR:000046884 located_in GO:0005788"
xref: Reactome:R-HSA-2268657 "PR:000046884 located_in GO:0005576"
intersection_of: has_part MOD:00037 ! 5-hydroxy-L-lysine
intersection_of: PR:P02458 ! collagen alpha-1(II) chain (human)
intersection_of: lacks_part SO:0000418 ! signal_peptide
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000046885
name: collagen alpha-1(II) chain, signal peptide removed 5-hydroxy-lysine, 3-hydroxy-proline and 4-hydroxy-proline form (human)
def: "A collagen alpha-1(II) chain (human) that has had the signal peptide removed and that includes at least one 5-hydroxy-lysine, at least one 3-hydroxy-proline and at least one 4-hydroxy-proline. UniProtKB:P02458, 26-1487, MOD:00037|MOD:00038|MOD:00039." [PRO:DNx, Reactome:R-HSA-2022968, Reactome:R-HSA-2268640]
comment: Category=organism-modification.
synonym: "hCOL2A1/SigPep-/5hL3hP4hP+" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P02458, 26-1487, MOD:00037|MOD:00038|MOD:00039" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-2022968 "PR:000046885 located_in GO:0005788"
xref: Reactome:R-HSA-2268640 "PR:000046885 located_in GO:0005576"
intersection_of: has_part MOD:00037 ! 5-hydroxy-L-lysine
intersection_of: has_part MOD:00038 ! 3-hydroxy-L-proline
intersection_of: has_part MOD:00039 ! 4-hydroxy-L-proline
intersection_of: PR:P02458 ! collagen alpha-1(II) chain (human)
intersection_of: lacks_part SO:0000418 ! signal_peptide
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000046882
name: collagen alpha-1(II) chain, signal peptide removed 3-hydroxy-proline and 4-hydroxy-proline form (human)
def: "A collagen alpha-1(II) chain (human) that has had the signal peptide removed and that includes at least one 3-hydroxy-proline and at least one 4-hydroxy-proline. UniProtKB:P02458, 26-1487, MOD:00038|MOD:00039." [PRO:DNx, Reactome:R-HSA-2022425, Reactome:R-HSA-2268684]
comment: Category=organism-modification.
synonym: "hCOL2A1/SigPep-/3hP4hP+" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P02458, 26-1487, MOD:00038|MOD:00039" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-2022425 "PR:000046882 located_in GO:0005788"
xref: Reactome:R-HSA-2268684 "PR:000046882 located_in GO:0005576"
intersection_of: has_part MOD:00038 ! 3-hydroxy-L-proline
intersection_of: has_part MOD:00039 ! 4-hydroxy-L-proline
intersection_of: PR:P02458 ! collagen alpha-1(II) chain (human)
intersection_of: lacks_part SO:0000418 ! signal_peptide
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000046883
name: collagen alpha-1(II) chain, signal peptide removed 4-hydroxy-proline form (human)
def: "A collagen alpha-1(II) chain (human) that has had the signal peptide removed and that includes at least one 4-hydroxy-proline. UniProtKB:P02458, 26-1487, MOD:00039." [PRO:DNx, Reactome:R-HSA-2022096, Reactome:R-HSA-2268699]
comment: Category=organism-modification.
synonym: "hCOL2A1/SigPep-/4HyPro+" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P02458, 26-1487, MOD:00039" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-2022096 "PR:000046883 located_in GO:0005788"
xref: Reactome:R-HSA-2268699 "PR:000046883 located_in GO:0005576"
intersection_of: has_part MOD:00039 ! 4-hydroxy-L-proline
intersection_of: PR:P02458 ! collagen alpha-1(II) chain (human)
intersection_of: lacks_part SO:0000418 ! signal_peptide
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000046881
name: collagen alpha-1(II) chain, signal peptide removed form (human)
def: "A collagen alpha-1(II) chain (human) that has had the signal peptide removed. UniProtKB:P02458, 26-1487." [PRO:DNx, Reactome:R-HSA-1980183, Reactome:R-HSA-2268655]
comment: Category=organism-modification.
synonym: "hCOL2A1/SigPep-" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P02458, 26-1487" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-1980183 "PR:000046881 located_in GO:0005788"
xref: Reactome:R-HSA-2268655 "PR:000046881 located_in GO:0005576"
intersection_of: PR:P02458 ! collagen alpha-1(II) chain (human)
intersection_of: lacks_part SO:0000418 ! signal_peptide
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens