[Term]
id: PR:000003281
name: interferon regulatory factor 7 isoform 1 phosphorylated 1
def: "An interferon regulatory factor 7 isoform 1 phosphorylated form that has been activated by phosphorylation on the Ser residues located in the C-terminal region. Phosphorylation stimulates the C-terminal autoinhibitory domain to attain a highly extended conformation triggering dimerization through extensive contacts to a second subunit. Example: UniProtKB:Q92985-1, Ser-477/Ser-479, MOD:00046." [PMID:10893229, PMID:14517278, PMID:20043992, TLR:AMM]
comment: Category=modification. Requested by=TLR.
synonym: "phospho IRF7" EXACT []
synonym: "IRF-7 active form" EXACT []
synonym: "IRF7/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "IRF-7 phosphorylated" EXACT []
is_a: PR:000003280 ! interferon regulatory factor 7 isoform 1 phosphorylated form
relationship: has_part MOD:00046 ! O-phospho-L-serine