[Term]
id: PR:000036646
name: dual specificity mitogen-activated protein kinase kinase 3 isoform 2 phosphorylated 1 (human)
def: "A dual specificity mitogen-activated protein kinase kinase 3 isoform 2 phosphorylated 1 in human. UniProtKB:P46734-2, Ser-189, MOD:00046|Thr-193, MOD:00047." [PMID:8622669, PRO:CNA]
comment: Category=organism-modification.
synonym: "hMAP2K3/iso:2/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P46734-2, Ser-189, MOD:00046|Thr-193, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000021946 ! dual specificity mitogen-activated protein kinase kinase 3 isoform 2 phosphorylated 1
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00047 ! O-phospho-L-threonine

[Term]
id: PR:P46734
name: dual specificity mitogen-activated protein kinase kinase 3 (human)
def: "A dual specificity mitogen-activated protein kinase kinase 3 that is encoded in the genome of human." [TLR:AMM, UniProtKB:P46734]
comment: Category=organism-gene.
synonym: "MEK3" RELATED Gene-based [UniProtKB:P46734]
synonym: "MKK3" RELATED Gene-based [UniProtKB:P46734]
synonym: "SKK2" RELATED Gene-based [UniProtKB:P46734]
synonym: "MAP2K3" RELATED Gene-based [UniProtKB:P46734]
synonym: "PRKMK3" RELATED Gene-based [UniProtKB:P46734]
synonym: "hMAP2K3" EXACT PRO-short-label [PRO:DNx]
synonym: "MEK 3 (human)" EXACT [UniProtKB:P46734]
synonym: "SAPKK2 (human)" EXACT [UniProtKB:P46734]
synonym: "MAPKK 3 (human)" EXACT [UniProtKB:P46734]
synonym: "SAPKK-2 (human)" EXACT [UniProtKB:P46734]
synonym: "SAPK kinase 2 (human)" EXACT [UniProtKB:P46734]
synonym: "MAPK/ERK kinase 3 (human)" EXACT [UniProtKB:P46734]
synonym: "MAP kinase kinase 3 (human)" EXACT [UniProtKB:P46734]
synonym: "stress-activated protein kinase kinase 2 (human)" EXACT [UniProtKB:P46734]
xref: Reactome:R-HSA-168051 "PR:P46734 located_in GO:0005829"
xref: Reactome:R-HSA-5211404 "PR:P46734 located_in GO:0005829"
xref: DTO:03100336
xref: UniProtKB:P46734
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000003284 ! dual specificity mitogen-activated protein kinase kinase 3
relationship: has_gene_template HGNC:6843 ! MAP2K3 (human)

[Term]
id: PR:P46734-1
name: dual specificity mitogen-activated protein kinase kinase 3 isoform 3 (human)
def: "A dual specificity mitogen-activated protein kinase kinase 3 isoform 1 that is encoded in the genome of human." [TLR:AMM]
comment: Category=organism-sequence.
synonym: "hMAP2K3/iso:3" EXACT PRO-short-label [PRO:DNx]
synonym: "dual specificity mitogen-activated protein kinase kinase 3 isoform 3b (human)" EXACT [UniProtKB:P46734]
xref: UniProtKB:P46734-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000021942 ! dual specificity mitogen-activated protein kinase kinase 3 isoform 1

[Term]
id: PR:000021991
name: dual specificity mitogen-activated protein kinase kinase 3 isoform 2 phosphorylated form
def: "A dual specificity mitogen-activated protein kinase kinase 3 isoform 2 that includes at least one phosphorylated residue." [PRO:CNA]
comment: Category=modification.
synonym: "MAP2K3/iso:2/PhosRes+" EXACT PRO-short-label [PRO:DNx]
intersection_of: has_part MOD:00696 ! phosphorylated residue
intersection_of: PR:000021944 ! dual specificity mitogen-activated protein kinase kinase 3 isoform 2

[Term]
id: PR:000003284
name: dual specificity mitogen-activated protein kinase kinase 3
def: "A dual specificity mitogen-activated protein kinase kinase 3/6 that is a translation product of the human MAP2K3 gene or a 1:1 ortholog thereof." [TLR:AMM]
comment: Category=gene. Requested by=TLR.
synonym: "MEK3" RELATED Gene-based []
synonym: "MKK3" RELATED Gene-based []
synonym: "SKK2" RELATED Gene-based []
synonym: "MEK 3" EXACT []
synonym: "MAP2K3" EXACT PRO-short-label [PRO:DNx]
synonym: "PRKMK3" RELATED Gene-based []
synonym: "MAPKK 3" EXACT []
synonym: "MAPK/ERK kinase 3" EXACT []
synonym: "MAP kinase kinase 3" EXACT []
xref: IUPHARobj:2064
is_a: PR:000021990 ! dual specificity mitogen-activated protein kinase kinase 3/6

[Term]
id: PR:O09110-1
name: dual specificity mitogen-activated protein kinase kinase 3 isoform 2 (mouse)
def: "A dual specificity mitogen-activated protein kinase kinase 3 isoform 1 that is encoded in the genome of mouse." [TLR:AMM]
comment: Category=organism-sequence.
synonym: "mMAP2K3/iso:2" EXACT PRO-short-label [PRO:DNx]
synonym: "dual specificity mitogen-activated protein kinase kinase 3 isoform 3b (mouse)" EXACT [UniProtKB:O09110]
xref: UniProtKB:O09110-1
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000021942 ! dual specificity mitogen-activated protein kinase kinase 3 isoform 1

[Term]
id: PR:O09110-2
name: dual specificity mitogen-activated protein kinase kinase 3 isoform 1 (mouse)
def: "A dual specificity mitogen-activated protein kinase kinase 3 isoform 2 that is encoded in the genome of mouse." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "mMAP2K3/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:O09110-2
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000021944 ! dual specificity mitogen-activated protein kinase kinase 3 isoform 2

[Term]
id: PR:P46734-3
name: dual specificity mitogen-activated protein kinase kinase 3 isoform h2 (human)
def: "A dual specificity mitogen-activated protein kinase kinase 3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P46734-3." [PRO:DNx, UniProtKB:P46734]
comment: Category=organism-sequence.
synonym: "hMAP2K3/iso:h2" EXACT PRO-short-label [PRO:DNx]
synonym: "dual specificity mitogen-activated protein kinase kinase 3 isoform 3c (human)" EXACT [UniProtKB:P46734]
xref: UniProtKB:P46734-3
is_a: PR:P46734 ! dual specificity mitogen-activated protein kinase kinase 3 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000021942
name: dual specificity mitogen-activated protein kinase kinase 3 isoform 1
def: "A dual specificity mitogen-activated protein kinase kinase 3 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P46734-1 or a 1:1 ortholog thereof." [PMID:8900184, TLR:AMM, UniProtKB:P46734-1]
comment: Category=sequence. Requested by=TLR.
synonym: "MKK3b" EXACT []
synonym: "MAP2K3/iso:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000003284 ! dual specificity mitogen-activated protein kinase kinase 3

[Term]
id: PR:000021944
name: dual specificity mitogen-activated protein kinase kinase 3 isoform 2
def: "A dual specificity mitogen-activated protein kinase kinase 3 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P46734-2 or a 1:1 ortholog thereof." [PMID:7839144, PRO:CNA]
comment: Category=sequence.
synonym: "MAP2K3/iso:2" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000003284 ! dual specificity mitogen-activated protein kinase kinase 3

[Term]
id: PR:000021946
name: dual specificity mitogen-activated protein kinase kinase 3 isoform 2 phosphorylated 1
def: "A dual specificity mitogen-activated protein kinase kinase 3 isoform 2 phosphorylated form that has been activated by dual phosphorylation on threonine and tyrosine residues. Example: UniProtKB:P46734-2, Ser-189, MOD:00046|Thr-193, MOD:00047." [PMID:7839144, PMID:8622669, TLR:AMM]
comment: Category=modification. Requested by=TLR.
synonym: "MAP2K3/iso:2/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "MKK3 isoform 3b active" EXACT []
is_a: PR:000021991 ! dual specificity mitogen-activated protein kinase kinase 3 isoform 2 phosphorylated form
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00047 ! O-phospho-L-threonine

[Term]
id: PR:P46734-2
name: dual specificity mitogen-activated protein kinase kinase 3 isoform 1 (human)
def: "A dual specificity mitogen-activated protein kinase kinase 3 isoform 2 that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "hMAP2K3/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P46734-2
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000021944 ! dual specificity mitogen-activated protein kinase kinase 3 isoform 2

[Term]
id: PR:000049827
name: dual specificity mitogen-activated protein kinase kinase 3 isoform 2 phosphorylated 2 (mouse)
def: "A dual specificity mitogen-activated protein kinase kinase 3 isoform 2 (mouse) that has been phosphorylated at Ser-218 and Thr-222. UniProtKB:O09110-1, Ser-218, MOD:00046|Thr-222, MOD:00047." [PMID:21183079, PRO:HJD]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:21183079). Evidence=(ECO:0006055, based on PMID:21183079).
synonym: "mMAP2K3/iso:2/Phos:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:O09110-1, Ser-218, MOD:00046|Thr-222, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:O09110-1 ! dual specificity mitogen-activated protein kinase kinase 3 isoform 2 (mouse)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:000049826
name: dual specificity mitogen-activated protein kinase kinase 3 isoform 2 phosphorylated 1 (mouse)
def: "A dual specificity mitogen-activated protein kinase kinase 3 isoform 2 (mouse) that has been phosphorylated at Ser-218. UniProtKB:O09110-1, Ser-218, MOD:00046." [PMID:21183079, PRO:HJD]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:21183079). Evidence=(ECO:0006055, based on PMID:21183079).
synonym: "mMAP2K3/iso:2/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:O09110-1, Ser-218, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:O09110-1 ! dual specificity mitogen-activated protein kinase kinase 3 isoform 2 (mouse)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:O09110
name: dual specificity mitogen-activated protein kinase kinase 3 (mouse)
def: "A dual specificity mitogen-activated protein kinase kinase 3 that is encoded in the genome of mouse." [OMA:O09110, PRO:DNx]
comment: Category=organism-gene.
synonym: "Mkk3" RELATED Gene-based [UniProtKB:O09110]
synonym: "Map2k3" RELATED Gene-based [UniProtKB:O09110]
synonym: "Prkmk3" RELATED Gene-based [UniProtKB:O09110]
synonym: "mMAP2K3" EXACT PRO-short-label [PRO:DNx]
synonym: "MEK 3 (mouse)" EXACT [UniProtKB:O09110]
synonym: "MAPKK 3 (mouse)" EXACT [UniProtKB:O09110]
synonym: "MAPK/ERK kinase 3 (mouse)" EXACT [UniProtKB:O09110]
synonym: "MAP kinase kinase 3 (mouse)" EXACT [UniProtKB:O09110]
xref: UniProtKB:O09110
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000003284 ! dual specificity mitogen-activated protein kinase kinase 3
relationship: has_gene_template MGI:1346868 ! Map2k3 (mouse)

[Term]
id: PR:000048297
name: dual specificity mitogen-activated protein kinase kinase 3 phosphorylated 1 (human)
def: "A dual specificity mitogen-activated protein kinase kinase 3 (human) that has been phosphorylated on the residue at the position equivalent to Ser-218, and phosphothreonine at position 222 of the amino acid sequence represented by UniProtKB:P46734. UniProtKB:P46734, Ser-218, MOD:00046|Thr-222, MOD:00047." [PRO:DNx, Reactome:R-HSA-167955, Reactome:R-HSA-450229]
comment: Category=organism-modification. Note: The modified sites indicated here (Ser-218/Thr-222) are referred to as Ser-189/Thr-193 in some manuscripts. [PRO:DAN, PMID:8622669]
synonym: "hMAP2K3/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P46734, Ser-218, MOD:00046|Thr-222, MOD:00047" EXACT PRO-proteoform-std [PRO:DAN]
xref: Reactome:R-HSA-167955 "PR:000048297 located_in GO:0005829"
xref: Reactome:R-HSA-450229 "PR:000048297 located_in GO:0005654"
is_a: PR:P46734 ! dual specificity mitogen-activated protein kinase kinase 3 (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q5ZL06
name: uncharacterized protein, MAP2K3 translation product (chicken)
def: "A dual specificity mitogen-activated protein kinase kinase 3 that is encoded in the genome of chicken." [PRO:DAN]
comment: Category=organism-gene.
synonym: "chick-MAP2K3" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q5ZL06
intersection_of: only_in_taxon NCBITaxon:9031 ! Gallus gallus
intersection_of: PR:000003284 ! dual specificity mitogen-activated protein kinase kinase 3