[Term]
id: PR:000028543
name: NF-kappa-B inhibitor alpha isoform 1
def: "An NF-kappa-B inhibitor alpha that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P25963-1 or a 1:1 ortholog thereof." [PMID:10329681, PRO:CNA]
comment: Category=sequence.
synonym: "NFKBIA/iso:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000003293 ! NF-kappa-B inhibitor alpha

[Term]
id: PR:000028550
name: NF-kappa-B inhibitor alpha isoform 1 phosphorylated 1 (mouse)
def: "An NF-kappa-B inhibitor alpha isoform 1 phosphorylated 1 in mouse. UniProtKB:Q9Z1E3-1, Ser-32/Ser-36, MOD:00046." [PMID:10097128, PMID:9990853, PRO:CNA]
comment: Category=organism-modification.
synonym: "mNFKBIA/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q9Z1E3-1, Ser-32/Ser-36, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000028545 ! NF-kappa-B inhibitor alpha isoform 1 phosphorylated 1
relationship: has_part MOD:00046 ! O-phospho-L-serine

[Term]
id: PR:000003293
name: NF-kappa-B inhibitor alpha
def: "An NF-kappa-B inhibitor that is a translation product of the human NFKBIA gene or a 1:1 ortholog thereof." [PMID:19302050, TLR:AMM]
comment: Category=gene. Requested by=TLR.
synonym: "IKBA" RELATED Gene-based []
synonym: "MAD3" RELATED Gene-based []
synonym: "NFKBI" RELATED Gene-based []
synonym: "NFKBIA" EXACT PRO-short-label [PRO:DNx]
synonym: "IKBalpha" EXACT []
synonym: "IkB-alpha" EXACT []
synonym: "IkappaBalpha" EXACT []
synonym: "I-kappa-B-alpha" EXACT []
synonym: "major histocompatibility complex enhancer-binding protein MAD3" EXACT []
is_a: PR:000003292 ! NF-kappa-B inhibitor

[Term]
id: PR:000028547
name: NF-kappa-B inhibitor alpha isoform 1 phosphorylated and ubiquitinated 1
def: "An NF-kappa-B inhibitor alpha isoform 1 that has been phosphorylated on the Ser residues in the motif KKx(8-11)SDGxxS and subsequently ubiquitinated on the Lys residues of the same motif. This modification targets the protein to proteosome degradation. Example: UniProtKB:P25963-1, Lys-21/Lys-22, MOD:01148|Ser-32/Ser-36, MOD:00046." [PMID:10329681, PMID:10837071, PRO:CNA]
comment: Category=modification.
synonym: "NFKBIA/iso:1/PhosUbiq:1" EXACT PRO-short-label [PRO:DNx]
synonym: "ubiquitinated phospho-IKb" RELATED []
is_a: PR:000028543 ! NF-kappa-B inhibitor alpha isoform 1
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:01148 ! ubiquitinylated lysine

[Term]
id: PR:000028546
name: NF-kappa-B inhibitor alpha isoform 1 phosphorylated 1 (human)
def: "An NF-kappa-B inhibitor alpha isoform 1 phosphorylated 1 in human. UniProtKB:P25963-1, Ser-32/Ser-36, MOD:00046." [PMID:10329681, PRO:CNA]
comment: Category=organism-modification. Kinase=("IKK complex"; PR:000026457).
synonym: "hNFKBIA/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P25963-1, Ser-32/Ser-36, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000028545 ! NF-kappa-B inhibitor alpha isoform 1 phosphorylated 1
relationship: has_part MOD:00046 ! O-phospho-L-serine

[Term]
id: PR:000028545
name: NF-kappa-B inhibitor alpha isoform 1 phosphorylated 1
def: "An NF-kappa-B inhibitor alpha isoform 1 that has been phosphorylated on the Ser residues in the motif KKx(8-11)SDGxxS. Example: UniProtKB:P25963-1, Ser-32/Ser-36, MOD:00046." [PMID:10329681, PMID:10837071, PRO:CNA]
comment: Category=modification.
synonym: "NFKBIA/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000028543 ! NF-kappa-B inhibitor alpha isoform 1
relationship: has_part MOD:00046 ! O-phospho-L-serine

[Term]
id: PR:000028551
name: NF-kappa-B inhibitor alpha isoform 1 phosphorylated and ubiquitinated 1 (mouse)
def: "An NF-kappa-B inhibitor alpha isoform 1 phosphorylated and ubiquitinated 1 in mouse. UniProtKB:Q9Z1E3-1, Lys-21/Lys-22, MOD:01148|Ser-32/Ser-36, MOD:00046." [PMID:10097128, PMID:9990853, PRO:CNA]
comment: Category=organism-modification.
synonym: "mNFKBIA/iso:1/PhosUbiq:1" EXACT PRO-short-label [PRO:DNx]
synonym: "ubiquitinated phospho-IKb (mouse)" RELATED []
synonym: "UniProtKB:Q9Z1E3-1, Lys-21/Lys-22, MOD:01148|Ser-32/Ser-36, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000028547 ! NF-kappa-B inhibitor alpha isoform 1 phosphorylated and ubiquitinated 1
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:01148 ! ubiquitinylated lysine

[Term]
id: PR:Q9Z1E3-1
name: NF-kappa-B inhibitor alpha isoform 1 (mouse)
def: "An NF-kappa-B inhibitor alpha isoform 1 that is encoded in the genome of mouse." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "mNFKBIA/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q9Z1E3-1
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000028543 ! NF-kappa-B inhibitor alpha isoform 1

[Term]
id: PR:000045728
name: NF-kappa-B inhibitor alpha phosphorylated 1 (human)
def: "An NF-kappa-B inhibitor alpha (human) that has been phosphorylated at Tyr-42. UniProtKB:P25963, Tyr-42, MOD:00048." [PMID:12429743, PMID:12432072, iPTMnet:P25963]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:12429743, PMID:12432072). Status=unreviewed.
synonym: "hNFKBIA/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P25963, Tyr-42, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:P25963 ! NF-kappa-B inhibitor alpha (human)
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000028548
name: NF-kappa-B inhibitor alpha isoform 1 phosphorylated and ubiquitinated 1 (human)
def: "An NF-kappa-B inhibitor alpha isoform 1 phosphorylated and ubiquitinated 1 in human. UniProtKB:P25963-1, Lys-21/Lys-22, MOD:01148|Ser-32/Ser-36, MOD:00046." [PMID:10329681, PRO:CNA]
comment: Category=organism-modification.
synonym: "hNFKBIA/iso:1/PhosUbiq:1" EXACT PRO-short-label [PRO:DNx]
synonym: "ubiquitinated phospho-IKb (human)" RELATED []
synonym: "UniProtKB:P25963-1, Lys-21/Lys-22, MOD:01148|Ser-32/Ser-36, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000028547 ! NF-kappa-B inhibitor alpha isoform 1 phosphorylated and ubiquitinated 1
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:01148 ! ubiquitinylated lysine

[Term]
id: PR:Q9Z1E3
name: NF-kappa-B inhibitor alpha (mouse)
def: "An NF-kappa-B inhibitor alpha that is encoded in the genome of mouse." [OMA:Q9Z1E3, PRO:DNx]
comment: Category=organism-gene.
synonym: "Ikba" RELATED Gene-based [UniProtKB:Q9Z1E3]
synonym: "Nfkbia" RELATED Gene-based [UniProtKB:Q9Z1E3]
synonym: "mNFKBIA" EXACT PRO-short-label [PRO:DNx]
synonym: "IkB-alpha (mouse)" EXACT [UniProtKB:Q9Z1E3]
synonym: "IkappaBalpha (mouse)" EXACT [UniProtKB:Q9Z1E3]
synonym: "I-kappa-B-alpha (mouse)" EXACT [UniProtKB:Q9Z1E3]
xref: UniProtKB:Q9Z1E3
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000003293 ! NF-kappa-B inhibitor alpha
relationship: has_gene_template MGI:104741 ! Nfkbia (mouse)

[Term]
id: PR:000048597
name: NF-kappa-B inhibitor alpha ubiquitinated form (human)
def: "An NF-kappa-B inhibitor alpha (human) that includes at least one ubiquitinated lysine. UniProtKB:P25963, MOD:01148." [PRO:DNx, Reactome:R-HSA-6782960]
comment: Category=organism-modification.
synonym: "hNFKBIA/UbiqLys+" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P25963, MOD:01148" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-6782960 "PR:000048597 located_in GO:0005829"
intersection_of: has_part MOD:01148 ! ubiquitinylated lysine
intersection_of: PR:P25963 ! NF-kappa-B inhibitor alpha (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q63746
name: NF-kappa-B inhibitor alpha (rat)
def: "An NF-kappa-B inhibitor alpha that is encoded in the genome of rat." [OMA:Q63746, PANTHER:PTHR24139:SF236, PRO:DNx]
comment: Category=organism-gene.
synonym: "Ikba" RELATED Gene-based [UniProtKB:Q63746]
synonym: "Nfkbia" RELATED Gene-based [UniProtKB:Q63746]
synonym: "rNFKBIA" EXACT PRO-short-label [PRO:DNx]
synonym: "RL/IF-1 (rat)" EXACT [UniProtKB:Q63746]
synonym: "IkB-alpha (rat)" EXACT [UniProtKB:Q63746]
synonym: "IkappaBalpha (rat)" EXACT [UniProtKB:Q63746]
synonym: "I-kappa-B-alpha (rat)" EXACT [UniProtKB:Q63746]
xref: UniProtKB:Q63746
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000003293 ! NF-kappa-B inhibitor alpha
relationship: has_gene_template RGD:3171 ! Nfkbia (rat)

[Term]
id: PR:Q91974
name: NF-kappa-B inhibitor alpha (chicken)
def: "An NF-kappa-B inhibitor alpha that is encoded in the genome of chicken." [OMA:Q91974, PRO:DNx]
comment: Category=organism-gene.
synonym: "IKBA" RELATED Gene-based [UniProtKB:Q91974]
synonym: "NFKBIA" RELATED Gene-based [UniProtKB:Q91974]
synonym: "chick-NFKBIA" EXACT PRO-short-label [PRO:DNx]
synonym: "IkB-alpha (chicken)" EXACT [UniProtKB:Q91974]
synonym: "IkappaBalpha (chicken)" EXACT [UniProtKB:Q91974]
synonym: "I-kappa-B-alpha (chicken)" EXACT [UniProtKB:Q91974]
synonym: "REL-associated protein pp40 (chicken)" EXACT [UniProtKB:Q91974]
xref: UniProtKB:Q91974
intersection_of: only_in_taxon NCBITaxon:9031 ! Gallus gallus
intersection_of: PR:000003293 ! NF-kappa-B inhibitor alpha

[Term]
id: PR:P25963
name: NF-kappa-B inhibitor alpha (human)
def: "An NF-kappa-B inhibitor alpha that is encoded in the genome of human." [TLR:AMM, UniProtKB:P25963]
comment: Category=organism-gene.
synonym: "IKBA" RELATED Gene-based [UniProtKB:P25963]
synonym: "MAD3" RELATED Gene-based [UniProtKB:P25963]
synonym: "NFKBI" RELATED Gene-based [UniProtKB:P25963]
synonym: "NFKBIA" RELATED Gene-based [UniProtKB:P25963]
synonym: "hNFKBIA" EXACT PRO-short-label [PRO:DNx]
synonym: "IkB-alpha (human)" EXACT [UniProtKB:P25963]
synonym: "IkappaBalpha (human)" EXACT [UniProtKB:P25963]
synonym: "I-kappa-B-alpha (human)" EXACT [UniProtKB:P25963]
synonym: "major histocompatibility complex enhancer-binding protein MAD3 (human)" EXACT [UniProtKB:P25963]
xref: Reactome:R-HSA-168151 "PR:P25963 located_in GO:0005829"
xref: Reactome:R-HSA-4656929 "PR:P25963 located_in GO:0005654"
xref: UniProtKB:P25963
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000003293 ! NF-kappa-B inhibitor alpha
relationship: has_gene_template HGNC:7797 ! NFKBIA (human)

[Term]
id: PR:P25963-1
name: NF-kappa-B inhibitor alpha isoform 1 (human)
def: "An NF-kappa-B inhibitor alpha isoform 1 that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "hNFKBIA/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P25963-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000028543 ! NF-kappa-B inhibitor alpha isoform 1