[Term] id: PR:P00519-2 name: tyrosine-protein kinase ABL1 isoform 2 (human) def: "A tyrosine-protein kinase ABL1 isoform 2 that is encoded in the genome of human." [PRO:CNA] comment: Category=organism-sequence. synonym: "hABL1/iso:2" EXACT PRO-short-label [PRO:DNx] synonym: "ABL1 IB (human)" EXACT [] synonym: "c-ABL IB (human)" RELATED [] synonym: "tyrosine-protein kinase ABL1 IB (human)" EXACT [] xref: UniProtKB:P00519-2 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000028611 ! tyrosine-protein kinase ABL1 isoform 2 [Term] id: PR:P00519-1 name: tyrosine-protein kinase ABL1 isoform 1 (human) def: "A tyrosine-protein kinase ABL1 isoform 1 that is encoded in the genome of human." [PRO:CNA] comment: Category=organism-sequence. Requested by=PubChem. synonym: "hABL1/iso:1" EXACT PRO-short-label [PRO:DNx] synonym: "ABL1 IA (human)" EXACT [] synonym: "c-ABL IA (human)" RELATED [] synonym: "tyrosine-protein kinase ABL1 IA (human)" EXACT [] xref: UniProtKB:P00519-1 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000028609 ! tyrosine-protein kinase ABL1 isoform 1 [Term] id: PR:000028614 name: tyrosine-protein kinase ABL1 isoform 2 acetylated 1 (human) def: "A tyrosine-protein kinase ABL1 isoform 2 acetylated 1 in human. UniProtKB:P00519-2, Lys-730, MOD:00064." [KAT:P00519-2, PMID:16648821, PRO:PD] comment: Category=organism-modification. Acetylase=("EP300"; PR:000007102). synonym: "hABL1/iso:2/Ac:1" EXACT PRO-short-label [PRO:DNx] synonym: "c-ABL IB acetylated" RELATED [] synonym: "UniProtKB:P00519-2, Lys-730, MOD:00064" EXACT PRO-proteoform-std [PRO:DNx] intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000028613 ! tyrosine-protein kinase ABL1 isoform 2 acetylated 1 relationship: has_part MOD:00064 ! N6-acetyl-L-lysine [Term] id: PR:000003582 name: tyrosine-protein kinase ABL1 def: "A protein that is a translation product of the human ABL1 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "ABL" RELATED Gene-based [] synonym: "ABL1" EXACT PRO-short-label [PRO:DNx] synonym: "JTK7" RELATED Gene-based [] synonym: "p150" BROAD [PRO:DNx] synonym: "proto-oncogene c-Abl" EXACT [] synonym: "Abelson tyrosine-protein kinase 1" EXACT [] synonym: "proto-oncogene tyrosine-protein kinase ABL1" EXACT [] synonym: "abelson murine leukemia viral oncogene homolog 1" EXACT [] xref: IUPHARobj:1923 is_a: PR:000000001 ! protein [Term] id: PR:000044506 name: tyrosine-protein kinase ABL1 phosphorylated 1 (human) def: "A tyrosine-protein kinase ABL1 (human) that is phosphorylated on a Thr residue within the 14-3-3 binding motif. Example: UniProtKB:P00519-1, Thr-735, MOD:00047." [PMID:15696159, PMID:16888623, PRO:CNA] comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:16888623). Evidence=(ECO:0000006, PMID:15696159). Note: Proteoform created based on papers selected via the eFIP text mining tool. synonym: "hABL1/Phos:1" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P00519-1, Thr-735, MOD:00047" NARROW PRO-proteoform-std [PRO:DNx] is_a: PR:P00519 ! tyrosine-protein kinase ABL1 (human) relationship: has_part MOD:00047 ! O-phospho-L-threonine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000046226 name: tyrosine-protein kinase ABL1 phosphorylated 2 (human) def: "A tyrosine-protein kinase ABL1 (human) that has been phosphorylated on the residue at the position equivalent to Ser-446 of the amino acid sequence represented by UniProtKB:P00519. UniProtKB:P00519, Ser-446, MOD:00046." [PRO:DAN, Reactome:R-HSA-5686576] comment: Category=organism-modification. Note: The modified site indicated here (Ser-446) is referred to as Ser-465 in the literature using the mouse sequence. [PRO:DAN, PMID:9168116] synonym: "hABL1/Phos:2" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P00519, Ser-446, MOD:00046" EXACT PRO-proteoform-std [PRO:DAN] xref: Reactome:R-HSA-5686576 "PR:000046226 located_in GO:0005654" is_a: PR:P00519 ! tyrosine-protein kinase ABL1 (human) relationship: has_part MOD:00046 ! O-phospho-L-serine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:P00519 name: tyrosine-protein kinase ABL1 (human) def: "A tyrosine-protein kinase ABL1 that is encoded in the genome of human." [PRO:DNx, UniProtKB:P00519] comment: Category=organism-gene. synonym: "ABL" RELATED Gene-based [UniProtKB:P00519] synonym: "ABL1" RELATED Gene-based [UniProtKB:P00519] synonym: "JTK7" RELATED Gene-based [UniProtKB:P00519] synonym: "hABL1" EXACT PRO-short-label [PRO:DNx] synonym: "p150 (human)" BROAD [UniProtKB:P00519] synonym: "proto-oncogene c-Abl (human)" EXACT [UniProtKB:P00519] synonym: "Abelson tyrosine-protein kinase 1 (human)" EXACT [UniProtKB:P00519] synonym: "Abelson murine leukemia viral oncogene homolog 1 (human)" EXACT [UniProtKB:P00519] xref: Reactome:R-HSA-375987 "PR:P00519 located_in GO:0005829" xref: Reactome:R-HSA-5686579 "PR:P00519 located_in GO:0005654" xref: DTO:03100006 xref: UniProtKB:P00519 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000003582 ! tyrosine-protein kinase ABL1 relationship: has_gene_template HGNC:76 ! ABL1 (human)