[Term]
id: PR:000003913
name: RAC-gamma serine/threonine-protein kinase
def: "An AKT kinase that is a translation product of the human AKT3 gene or a 1:1 ortholog thereof." [PRO:CNA]
comment: Category=gene.
synonym: "AKT3" EXACT PRO-short-label [PRO:DNx]
synonym: "PKBG" RELATED Gene-based []
synonym: "STK-2" EXACT []
synonym: "PKB gamma" EXACT []
synonym: "RAC-PK-gamma" EXACT []
synonym: "protein kinase Akt-3" EXACT []
synonym: "protein kinase B gamma" EXACT []
xref: IUPHARobj:2286
is_a: PR:000029189 ! AKT kinase

[Term]
id: PR:Q9Y243
name: RAC-gamma serine/threonine-protein kinase (human)
def: "A RAC-gamma serine/threonine-protein kinase that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q9Y243]
comment: Category=organism-gene.
synonym: "AKT3" RELATED Gene-based [UniProtKB:Q9Y243]
synonym: "PKBG" RELATED Gene-based [UniProtKB:Q9Y243]
synonym: "hAKT3" EXACT PRO-short-label [PRO:DNx]
synonym: "STK-2 (human)" EXACT [UniProtKB:Q9Y243]
synonym: "PKB gamma (human)" EXACT [UniProtKB:Q9Y243]
synonym: "RAC-PK-gamma (human)" EXACT [UniProtKB:Q9Y243]
synonym: "protein kinase Akt-3 (human)" EXACT [UniProtKB:Q9Y243]
synonym: "protein kinase B gamma (human)" EXACT [UniProtKB:Q9Y243]
xref: Reactome:R-HSA-2976006 "PR:Q9Y243 located_in GO:0005886"
xref: Reactome:R-HSA-2976007 "PR:Q9Y243 located_in GO:0005829"
xref: DTO:03100021
xref: UniProtKB:Q9Y243
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000003913 ! RAC-gamma serine/threonine-protein kinase
relationship: has_gene_template HGNC:393 ! AKT3 (human)

[Term]
id: PR:000046301
name: RAC-gamma serine/threonine-protein kinase phosphorylated 1 (human)
def: "A RAC-gamma serine/threonine-protein kinase (human) that has been phosphorylated on the residue at the position equivalent to Ser-472 of the amino acid sequence represented by UniProtKB:Q9Y243. UniProtKB:Q9Y243, Ser-472, MOD:00046." [PRO:DNx, Reactome:R-HSA-3009363]
comment: Category=organism-modification.
synonym: "hAKT3/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q9Y243, Ser-472, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-3009363 "PR:000046301 located_in GO:0005886"
is_a: PR:Q9Y243 ! RAC-gamma serine/threonine-protein kinase (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000046303
name: RAC-gamma serine/threonine-protein kinase phosphorylated 3 (human)
def: "A RAC-gamma serine/threonine-protein kinase (human) that has been phosphorylated on the residue at the position equivalent to Thr-305, and phosphoserine at position 472 of the amino acid sequence represented by UniProtKB:Q9Y243. UniProtKB:Q9Y243, Thr-305, MOD:00047|Ser-472, MOD:00046." [PRO:DNx, Reactome:R-HSA-3009365, Reactome:R-HSA-3009367]
comment: Category=organism-modification.
synonym: "hAKT3/Phos:3" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q9Y243, Thr-305, MOD:00047|Ser-472, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-3009365 "PR:000046303 located_in GO:0005654"
xref: Reactome:R-HSA-3009367 "PR:000046303 located_in GO:0005829"
is_a: PR:Q9Y243 ! RAC-gamma serine/threonine-protein kinase (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000046302
name: RAC-gamma serine/threonine-protein kinase phosphorylated 2 (human)
def: "A RAC-gamma serine/threonine-protein kinase (human) that has been phosphorylated on the residue at the position equivalent to Thr-305 of the amino acid sequence represented by UniProtKB:Q9Y243. UniProtKB:Q9Y243, Thr-305, MOD:00047." [PRO:DNx, Reactome:R-HSA-3009370]
comment: Category=organism-modification.
synonym: "hAKT3/Phos:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q9Y243, Thr-305, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-3009370 "PR:000046302 located_in GO:0005829"
is_a: PR:Q9Y243 ! RAC-gamma serine/threonine-protein kinase (human)
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q9Y243-1
name: RAC-gamma serine/threonine-protein kinase isoform 1 (human)
def: "A RAC-gamma serine/threonine-protein kinase isoform 1 that is encoded in the genome of human." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "hAKT3/iso:1" EXACT PRO-short-label [PRO:DNx]
synonym: "RAC-gamma serine/threonine-protein kinase isoform PKB gamma (human)" EXACT [UniProtKB:Q9Y243]
xref: UniProtKB:Q9Y243-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000044098 ! RAC-gamma serine/threonine-protein kinase isoform 1

[Term]
id: PR:Q9Y243-2
name: RAC-gamma serine/threonine-protein kinase isoform h2 (human)
def: "A RAC-gamma serine/threonine-protein kinase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9Y243-2." [PRO:DNx, UniProtKB:Q9Y243]
comment: Category=organism-sequence.
synonym: "hAKT3/iso:h2" EXACT PRO-short-label [PRO:DNx]
synonym: "RAC-gamma serine/threonine-protein kinase isoform PKB gamma 1 (human)" EXACT [UniProtKB:Q9Y243]
xref: UniProtKB:Q9Y243-2
is_a: PR:Q9Y243 ! RAC-gamma serine/threonine-protein kinase (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens