[Term] id: PR:000004155 name: apolipoprotein E def: "A protein that is a translation product of the human APOE gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "APOE" EXACT PRO-short-label [PRO:DNx] synonym: "apo-E" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:P02649 name: apolipoprotein E (human) def: "An apolipoprotein E that is encoded in the genome of human." [PRO:DNx, UniProtKB:P02649] comment: Category=organism-gene. synonym: "APOE" RELATED Gene-based [UniProtKB:P02649] synonym: "hAPOE" EXACT PRO-short-label [PRO:DNx] synonym: "apo-E (human)" EXACT [UniProtKB:P02649] xref: UniProtKB:P02649 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000004155 ! apolipoprotein E relationship: has_gene_template HGNC:613 ! APOE (human) [Term] id: PR:000052489 name: apolipoprotein E O-glycosylated 6 (human) def: "An apolipoprotein E (human) that has been O-glycosylated at the residue equivalent to Thr-212 of the amino acid sequence represented by UniProtKB:P02649-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P02649-1, Thr-212, MOD:00005~GNO:G43417UB." [GlyGen:P02649-1, PMID:23234360, PMID:30459171, PRO:DNx] comment: Category=organism-modification. Requested by=GlyGen. synonym: "hAPOE/OGlyco:6" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P02649-1, Thr-212, MOD:00005~GNO:G43417UB" NARROW PRO-proteoform-std [PRO:DNx] is_a: PR:P02649 ! apolipoprotein E (human) relationship: has_part GNO:G43417UB ! G43417UB relationship: has_part MOD:00005 ! O-glycosyl-L-threonine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000052488 name: apolipoprotein E O-glycosylated 5 (human) def: "An apolipoprotein E (human) that has been O-glycosylated at the residue equivalent to Thr-212 of the amino acid sequence represented by UniProtKB:P02649-1, in which the glycan composition is represented by GlyTouCan:G29068FM. Example: UniProtKB:P02649-1, Thr-212, MOD:00005~GNO:G29068FM." [GlyGen:P02649-1, PMID:30459171, PRO:DNx] comment: Category=organism-modification. Requested by=GlyGen. synonym: "hAPOE/OGlyco:5" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P02649-1, Thr-212, MOD:00005~GNO:G29068FM" NARROW PRO-proteoform-std [PRO:DNx] is_a: PR:P02649 ! apolipoprotein E (human) relationship: has_part GNO:G29068FM ! G29068FM relationship: has_part MOD:00005 ! O-glycosyl-L-threonine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000046364 name: apolipoprotein E, signal peptide removed form (human) def: "An apolipoprotein E (human) that has had the signal peptide removed. UniProtKB:P02649, 19-317." [PRO:DNx, Reactome:R-HSA-174615, Reactome:R-HSA-174646, Reactome:R-HSA-174651, Reactome:R-HSA-174766, Reactome:R-HSA-174804, Reactome:R-HSA-2429687, Reactome:R-HSA-3221641] comment: Category=organism-modification. synonym: "hAPOE/SigPep-" EXACT PRO-short-label [PRO:DNx] synonym: "PRO_0000001987" EXACT PRO-proteoform-ftid [PRO:DNx] synonym: "UniProtKB:P02649, 19-317" EXACT PRO-proteoform-std [PRO:DNx] xref: Reactome:R-HSA-174615 "PR:000046364 located_in GO:0005886" xref: Reactome:R-HSA-174646 "PR:000046364 located_in GO:0005576" xref: Reactome:R-HSA-174651 "PR:000046364 located_in GO:0030669" xref: Reactome:R-HSA-174766 "PR:000046364 located_in GO:0010008" xref: Reactome:R-HSA-174804 "PR:000046364 located_in GO:0031904" xref: Reactome:R-HSA-3221641 "PR:000046364 located_in GO:0071682" xref: Reactome:R-HSA-2429687 "PR:000046364 located_in GO:0005769" xref: Reactome:R-HSA-6784908 "PR:000046364 located_in GO:0005788" intersection_of: PR:P02649 ! apolipoprotein E (human) intersection_of: lacks_part SO:0000418 ! signal_peptide relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000052490 name: apolipoprotein E O-glycosylated 7 (human) def: "An apolipoprotein E (human) that has been O-glycosylated at the residue equivalent to Thr-212 of the amino acid sequence represented by UniProtKB:P02649-1, in which the glycan composition is represented by GlyTouCan:G53434XO. Example: UniProtKB:P02649-1, Thr-212, MOD:00005~GNO:G53434XO." [GlyGen:P02649-1, PMID:23234360, PRO:DNx] comment: Category=organism-modification. Requested by=GlyGen. synonym: "hAPOE/OGlyco:7" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P02649-1, Thr-212, MOD:00005~GNO:G53434XO" NARROW PRO-proteoform-std [PRO:DNx] is_a: PR:P02649 ! apolipoprotein E (human) relationship: has_part GNO:G53434XO ! G53434XO relationship: has_part MOD:00005 ! O-glycosyl-L-threonine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000052491 name: apolipoprotein E O-glycosylated 8 (human) def: "An apolipoprotein E (human) that has been O-glycosylated at the residue equivalent to Thr-26 of the amino acid sequence represented by UniProtKB:P02649-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P02649-1, Thr-26, MOD:00005~GNO:G43417UB." [GlyGen:P02649-1, PMID:23234360, PRO:DNx] comment: Category=organism-modification. Requested by=GlyGen. synonym: "hAPOE/OGlyco:8" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P02649-1, Thr-26, MOD:00005~GNO:G43417UB" NARROW PRO-proteoform-std [PRO:DNx] is_a: PR:P02649 ! apolipoprotein E (human) relationship: has_part GNO:G43417UB ! G43417UB relationship: has_part MOD:00005 ! O-glycosyl-L-threonine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000052492 name: apolipoprotein E O-glycosylated 9 (human) def: "An apolipoprotein E (human) that has been O-glycosylated at the residue equivalent to Thr-307 of the amino acid sequence represented by UniProtKB:P02649-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P02649-1, Thr-307, MOD:00005~GNO:G43417UB." [GlyGen:P02649-1, PMID:30459171, PRO:DNx] comment: Category=organism-modification. Requested by=GlyGen. synonym: "hAPOE/OGlyco:9" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P02649-1, Thr-307, MOD:00005~GNO:G43417UB" NARROW PRO-proteoform-std [PRO:DNx] is_a: PR:P02649 ! apolipoprotein E (human) relationship: has_part GNO:G43417UB ! G43417UB relationship: has_part MOD:00005 ! O-glycosyl-L-threonine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000052493 name: apolipoprotein E O-glycosylated 10 (human) def: "An apolipoprotein E (human) that has been O-glycosylated at the residue equivalent to Thr-36 of the amino acid sequence represented by UniProtKB:P02649-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P02649-1, Thr-36, MOD:00005~GNO:G43417UB." [GlyGen:P02649-1, PMID:23234360, PMID:30459171, PRO:DNx] comment: Category=organism-modification. Requested by=GlyGen. synonym: "hAPOE/OGlyco:10" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P02649-1, Thr-36, MOD:00005~GNO:G43417UB" NARROW PRO-proteoform-std [PRO:DNx] is_a: PR:P02649 ! apolipoprotein E (human) relationship: has_part GNO:G43417UB ! G43417UB relationship: has_part MOD:00005 ! O-glycosyl-L-threonine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000052487 name: apolipoprotein E O-glycosylated 4 (human) def: "An apolipoprotein E (human) that has been O-glycosylated at the residue equivalent to Ser-314 of the amino acid sequence represented by UniProtKB:P02649-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P02649-1, Ser-314, MOD:00002~GNO:G43417UB." [GlyGen:P02649-1, PMID:23234360, PRO:DNx] comment: Category=organism-modification. Requested by=GlyGen. synonym: "hAPOE/OGlyco:4" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P02649-1, Ser-314, MOD:00002~GNO:G43417UB" NARROW PRO-proteoform-std [PRO:DNx] is_a: PR:P02649 ! apolipoprotein E (human) relationship: has_part GNO:G43417UB ! G43417UB relationship: has_part MOD:00002 ! O-glycosyl-L-serine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000052486 name: apolipoprotein E O-glycosylated 3 (human) def: "An apolipoprotein E (human) that has been O-glycosylated at the residue equivalent to Ser-308 of the amino acid sequence represented by UniProtKB:P02649-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P02649-1, Ser-308, MOD:00002~GNO:G43417UB." [GlyGen:P02649-1, PMID:23234360, PMID:30459171, PRO:DNx] comment: Category=organism-modification. Requested by=GlyGen. synonym: "hAPOE/OGlyco:3" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P02649-1, Ser-308, MOD:00002~GNO:G43417UB" NARROW PRO-proteoform-std [PRO:DNx] is_a: PR:P02649 ! apolipoprotein E (human) relationship: has_part GNO:G43417UB ! G43417UB relationship: has_part MOD:00002 ! O-glycosyl-L-serine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000052485 name: apolipoprotein E O-glycosylated 2 (human) def: "An apolipoprotein E (human) that has been O-glycosylated at the residue equivalent to Ser-308 of the amino acid sequence represented by UniProtKB:P02649-1, in which the glycan composition is represented by GlyTouCan:G29068FM. Example: UniProtKB:P02649-1, Ser-308, MOD:00002~GNO:G29068FM." [GlyGen:P02649-1, PMID:30459171, PRO:DNx] comment: Category=organism-modification. Requested by=GlyGen. synonym: "hAPOE/OGlyco:2" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P02649-1, Ser-308, MOD:00002~GNO:G29068FM" NARROW PRO-proteoform-std [PRO:DNx] is_a: PR:P02649 ! apolipoprotein E (human) relationship: has_part GNO:G29068FM ! G29068FM relationship: has_part MOD:00002 ! O-glycosyl-L-serine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000052484 name: apolipoprotein E O-glycosylated 1 (human) def: "An apolipoprotein E (human) that has been O-glycosylated at the residue equivalent to Ser-215 of the amino acid sequence represented by UniProtKB:P02649-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P02649-1, Ser-215, MOD:00002~GNO:G43417UB." [GlyGen:P02649-1, PMID:30459171, PRO:DNx] comment: Category=organism-modification. Requested by=GlyGen. synonym: "hAPOE/OGlyco:1" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P02649-1, Ser-215, MOD:00002~GNO:G43417UB" NARROW PRO-proteoform-std [PRO:DNx] is_a: PR:P02649 ! apolipoprotein E (human) relationship: has_part GNO:G43417UB ! G43417UB relationship: has_part MOD:00002 ! O-glycosyl-L-serine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens