[Term]
id: PR:000035661
name: aurora kinase B unphosphorylated form (human)
def: "An aurora kinase B unphosphorylated form in human." [PMID:22024163, PRO:KER]
comment: Category=organism-modification.
synonym: "hAURKB/PhosRes-" EXACT PRO-short-label [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000035660 ! aurora kinase B unphosphorylated form

[Term]
id: PR:Q96GD4
name: aurora kinase B (human)
def: "An aurora kinase B that is encoded in the genome of human." [PMID:12719470, PMID:15592459, PMID:15917996, PMID:17617734, PMID:20624902, PMID:21658950, PMID:22732840, PRO:KER]
comment: Category=organism-gene.
synonym: "AIK2" RELATED Gene-based [UniProtKB:Q96GD4]
synonym: "AIM1" RELATED Gene-based [UniProtKB:Q96GD4]
synonym: "ARK2" RELATED Gene-based [UniProtKB:Q96GD4]
synonym: "STK1" RELATED Gene-based [UniProtKB:Q96GD4]
synonym: "STK5" RELATED Gene-based [UniProtKB:Q96GD4]
synonym: "AIRK2" RELATED Gene-based [UniProtKB:Q96GD4]
synonym: "AURKB" RELATED Gene-based [UniProtKB:Q96GD4]
synonym: "STK12" RELATED Gene-based [UniProtKB:Q96GD4]
synonym: "hAURKB" EXACT PRO-short-label [PRO:DNx]
synonym: "AIM-1 (human)" EXACT [UniProtKB:Q96GD4]
synonym: "ARK-2 (human)" EXACT [UniProtKB:Q96GD4]
synonym: "STK-1 (human)" BROAD [UniProtKB:Q96GD4]
synonym: "aurora 1 (human)" EXACT [UniProtKB:Q96GD4]
synonym: "aurora-related kinase 2 (human)" EXACT [UniProtKB:Q96GD4]
synonym: "aurora/IPL1-related kinase 2 (human)" EXACT [UniProtKB:Q96GD4]
synonym: "serine/threonine-protein kinase 5 (human)" EXACT [UniProtKB:Q96GD4]
synonym: "serine/threonine-protein kinase 12 (human)" EXACT []
synonym: "serine/threonine-protein kinase aurora-B (human)" EXACT [UniProtKB:Q96GD4]
synonym: "aurora- and IPL1-like midbody-associated protein 1 (human)" EXACT [UniProtKB:Q96GD4]
xref: Reactome:R-HSA-174231 "PR:Q96GD4 located_in GO:0005829"
xref: Reactome:R-HSA-4655360 "PR:Q96GD4 located_in GO:0005654"
xref: DTO:03100036
xref: UniProtKB:Q96GD4
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000004517 ! aurora kinase B
relationship: has_gene_template HGNC:11390 ! AURKB (human)

[Term]
id: PR:000035663
name: aurora kinase B phosphorylated 1 (human)
def: "An aurora kinase B phosphorylated 1 in human. This phosphorylated form is present during prometaphase, metaphase, and loss of tension on kinetochores (taxol). UniProtKB:Q96GD4, Ser-331, MOD:00046." [PMID:17276342, PMID:22024163, PMID:22024163, PMID:23321637, PRO:CNA, PRO:KER]
comment: Category=organism-modification. Kinase=("Chk1"; PR:O14757; Ser-331). Evidence=(ECO:0000006, based on PMID:22024163).
synonym: "hAURKB/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "hAURKB active form" RELATED []
synonym: "UniProtKB:Q96GD4, Ser-331, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000035662 ! aurora kinase B phosphorylated 1
relationship: has_part MOD:00046 ! O-phospho-L-serine

[Term]
id: PR:000004517
name: aurora kinase B
def: "An aurora kinase that is a translation product of the human AURKB gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "AIK2" RELATED Gene-based []
synonym: "AIM1" RELATED Gene-based []
synonym: "ARK2" RELATED Gene-based []
synonym: "Stk1" RELATED []
synonym: "Stk5" RELATED []
synonym: "AIM-1" EXACT []
synonym: "AIRK2" RELATED Gene-based []
synonym: "ARK-2" EXACT []
synonym: "AURKB" EXACT PRO-short-label [PRO:DNx]
synonym: "STK-1" RELATED []
synonym: "STK12" RELATED Gene-based []
synonym: "aurora 1" EXACT []
synonym: "aurora-related kinase 2" EXACT []
synonym: "aurora/IPL1-related kinase 2" EXACT []
synonym: "serine/threonine-protein kinase 5" EXACT []
synonym: "serine/threonine-protein kinase 12" EXACT []
synonym: "serine/threonine-protein kinase aurora-B" EXACT []
synonym: "aurora- and Ipl1-like midbody-associated protein 1" EXACT []
xref: IUPHARobj:1937
is_a: PR:000035365 ! aurora kinase

[Term]
id: PR:Q96GD4-1
name: aurora kinase B isoform h1 (human)
def: "An aurora kinase B (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q96GD4-1." [PRO:DNx, UniProtKB:Q96GD4]
comment: Category=organism-sequence.
synonym: "hAURKB/iso:h1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q96GD4-1
is_a: PR:Q96GD4 ! aurora kinase B (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000046026
name: aurora kinase B phosphorylated 2 (human)
def: "An aurora kinase B (human) that has been phosphorylated on the residue at the position equivalent to Thr-232 of the amino acid sequence represented by UniProtKB:Q96GD4-1. Example: UniProtKB:Q96GD4-1, Thr-232, MOD:00047." [PMID:14722118, PMID:18767990, iPTMnet:Q96GD4]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:14722118, PMID:18767990). Status=unreviewed.
synonym: "hAURKB/Phos:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q96GD4-1, Thr-232, MOD:00047" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:Q96GD4 ! aurora kinase B (human)
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q96GD4-5
name: aurora kinase B isoform h5 (human)
def: "An aurora kinase B (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q96GD4-5." [PRO:DNx, UniProtKB:Q96GD4]
comment: Category=organism-sequence.
synonym: "hAURKB/iso:h5" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q96GD4-5
is_a: PR:Q96GD4 ! aurora kinase B (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q96GD4-4
name: aurora kinase B isoform h4 (human)
def: "An aurora kinase B (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q96GD4-4." [PRO:DNx, UniProtKB:Q96GD4]
comment: Category=organism-sequence.
synonym: "hAURKB/iso:h4" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q96GD4-4
is_a: PR:Q96GD4 ! aurora kinase B (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q96GD4-3
name: aurora kinase B isoform h3 (human)
def: "An aurora kinase B (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q96GD4-3." [PRO:DNx, UniProtKB:Q96GD4]
comment: Category=organism-sequence.
synonym: "hAURKB/iso:h3" EXACT PRO-short-label [PRO:DNx]
synonym: "aurora kinase B isoform aurkb-sv2 (human)" EXACT [UniProtKB:Q96GD4]
xref: UniProtKB:Q96GD4-3
is_a: PR:Q96GD4 ! aurora kinase B (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q96GD4-2
name: aurora kinase B isoform h2 (human)
def: "An aurora kinase B (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q96GD4-2." [PRO:DNx, UniProtKB:Q96GD4]
comment: Category=organism-sequence.
synonym: "hAURKB/iso:h2" EXACT PRO-short-label [PRO:DNx]
synonym: "aurora kinase B isoform aurkb-sv1 (human)" EXACT [UniProtKB:Q96GD4]
xref: UniProtKB:Q96GD4-2
is_a: PR:Q96GD4 ! aurora kinase B (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000046440
name: aurora kinase B sumoylated 1 (human)
def: "An aurora kinase B (human) that has been post-translationally modified to include sumoylated lysine at position 202 of the amino acid sequence represented by UniProtKB:Q96GD4. UniProtKB:Q96GD4, Lys-202, MOD:01149." [PRO:DNx, Reactome:R-HSA-4655414]
comment: Category=organism-modification.
synonym: "hAURKB/Sumo:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q96GD4, Lys-202, MOD:01149" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-4655414 "PR:000046440 located_in GO:0005829"
is_a: PR:Q96GD4 ! aurora kinase B (human)
relationship: has_part MOD:01149 ! sumoylated lysine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens