[Term] id: PR:000045543 name: RecQ-like DNA helicase BLM phosphorylated 1 (human) def: "A RecQ-like DNA helicase BLM (human) that has been phosphorylated on a Ser residue equivalent to Ser-646 of the amino acid sequence represented by UniProtKB:P54132, and additional Ser/Thr residues within the [R/K]xx[S/T][hydrophobic]xx motifs. UniProtKB:P54132, Ser-646, MOD:00046|MOD:00047." [PMID:20719863, PRO:CNA, PRO:QW] comment: Category=organism-modification. Kinase=("Chk1"; PR:O14757; Ser-646). Evidence=(ECO:0000006, based on PMID:20719863). Note: Proteoform created based on papers selected via the eFIP text mining tool. synonym: "pSer646BLM" RELATED [] synonym: "hBLM/Phos:1" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P54132, Ser-646, MOD:00046|MOD:00047" EXACT PRO-proteoform-std [PRO:DNx] is_a: PR:P54132 ! RecQ-like DNA helicase BLM (human) relationship: has_part MOD:00046 ! O-phospho-L-serine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:O88700 name: RecQ-like DNA helicase BLM (mouse) def: "A RecQ-like DNA helicase BLM that is encoded in the genome of mouse." [OMA:O88700, PRO:DNx] comment: Category=organism-gene. synonym: "Blm" RELATED Gene-based [UniProtKB:O88700] synonym: "mBLM" EXACT PRO-short-label [PRO:DNx] synonym: "RecQ helicase homolog (mouse)" EXACT [UniProtKB:O88700] synonym: "Bloom syndrome protein homolog (mouse)" EXACT [UniProtKB:O88700] xref: UniProtKB:O88700 intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus intersection_of: PR:000004759 ! RecQ-like DNA helicase BLM relationship: has_gene_template MGI:1328362 ! Blm (mouse) [Term] id: PR:000045834 name: RecQ-like DNA helicase BLM phosphorylated 2 (human) def: "A RecQ-like DNA helicase BLM (human) that has been phosphorylated at Thr-99. UniProtKB:P54132, Thr-99, MOD:00047." [PMID:16199871, iPTMnet:P54132] comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:16199871). Status=unreviewed. synonym: "hBLM/Phos:2" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P54132, Thr-99, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx] is_a: PR:P54132 ! RecQ-like DNA helicase BLM (human) relationship: has_part MOD:00047 ! O-phospho-L-threonine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000004759 name: RecQ-like DNA helicase BLM def: "A protein that is a translation product of the human BLM gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "BLM" EXACT PRO-short-label [PRO:DNx] synonym: "RECQ2" RELATED Gene-based [] synonym: "RecQ2" EXACT [] synonym: "RECQL3" RELATED Gene-based [] synonym: "RecQ protein-like 3" EXACT [] synonym: "Bloom syndrome protein" EXACT [] synonym: "DNA helicase, RecQ-like type 2" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:O18017 name: RecQ-like DNA helicase blm-1 (worm) def: "A RecQ-like DNA helicase BLM that is encoded in the genome of worm." [PANTHER:PTHR13710:SF14, PRO:DNx] comment: Category=organism-gene. synonym: "blm-1" RELATED Gene-based [UniProtKB:O18017] synonym: "him-6" RELATED Gene-based [UniProtKB:O18017] synonym: "T04A11.6" RELATED Gene-based [UniProtKB:O18017] synonym: "BLM (worm)" EXACT PRO-short-label [PRO:DNx] synonym: "RecQ helicase homolog (worm)" EXACT [UniProtKB:O18017] synonym: "Bloom syndrome protein homolog (worm)" EXACT [UniProtKB:O18017] synonym: "high incidence of males protein 6 (worm)" EXACT [UniProtKB:O18017] xref: UniProtKB:O18017 intersection_of: only_in_taxon NCBITaxon:6239 ! Caenorhabditis elegans intersection_of: PR:000004759 ! RecQ-like DNA helicase BLM relationship: has_gene_template WormBase:WBGene00001865 ! him-6 (worm) [Term] id: PR:000046485 name: RecQ-like DNA helicase BLM sumoylated 1 (human) def: "A RecQ-like DNA helicase BLM (human) that has been post-translationally modified to include sumoylated lysine at positions 317, 331, 344 and 347 of the amino acid sequence represented by UniProtKB:P54132. UniProtKB:P54132, Lys-317/Lys-331/Lys-344/Lys-347, MOD:01149." [PRO:DNx, Reactome:R-HSA-4568883] comment: Category=organism-modification. synonym: "hBLM/Sumo:1" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P54132, Lys-317/Lys-331/Lys-344/Lys-347, MOD:01149" EXACT PRO-proteoform-std [PRO:DNx] xref: Reactome:R-HSA-4568883 "PR:000046485 located_in GO:0005654" is_a: PR:P54132 ! RecQ-like DNA helicase BLM (human) relationship: has_part MOD:01149 ! sumoylated lysine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:Q9VGI8 name: RecQ-like DNA helicase Blm (fruit fly) def: "A RecQ-like DNA helicase BLM that is encoded in the genome of fruit fly." [PANTHER:PTHR13710:SF14, PRO:DNx] comment: Category=organism-gene. synonym: "Blm" RELATED Gene-based [UniProtKB:Q9VGI8] synonym: "Dmblm" EXACT [UniProtKB:Q9VGI8] synonym: "CG6920" RELATED Gene-based [UniProtKB:Q9VGI8] synonym: "mus309" RELATED Gene-based [UniProtKB:Q9VGI8] synonym: "fly-BLM" EXACT PRO-short-label [PRO:DNx] synonym: "RecQ helicase homolog (fruit fly)" EXACT [UniProtKB:Q9VGI8] synonym: "mutagen-sensitive protein 309 (fruit fly)" EXACT [UniProtKB:Q9VGI8] synonym: "Bloom syndrome protein homolog (fruit fly)" EXACT [UniProtKB:Q9VGI8] synonym: "Bloom syndrome helicase ortholog (fruit fly)" EXACT [UniProtKB:Q9VGI8] xref: UniProtKB:Q9VGI8 intersection_of: only_in_taxon NCBITaxon:7227 ! Drosophila melanogaster intersection_of: PR:000004759 ! RecQ-like DNA helicase BLM relationship: has_gene_template FlyBase:FBgn0002906 ! Blm (fruit fly) [Term] id: PR:P54132 name: RecQ-like DNA helicase BLM (human) def: "A RecQ-like DNA helicase BLM that is encoded in the genome of human." [PRO:DNx, UniProtKB:P54132] comment: Category=organism-gene. synonym: "BLM" RELATED Gene-based [UniProtKB:P54132] synonym: "hBLM" EXACT PRO-short-label [PRO:DNx] synonym: "RECQ2" RELATED Gene-based [UniProtKB:P54132] synonym: "RECQL3" RELATED Gene-based [UniProtKB:P54132] synonym: "RecQ protein-like 3 (human)" EXACT [UniProtKB:P54132] synonym: "Bloom syndrome protein (human)" EXACT [UniProtKB:P54132] synonym: "DNA helicase, RecQ-like type 2 (human)" EXACT [UniProtKB:P54132] xref: Reactome:R-HSA-174881 "PR:P54132 located_in GO:0005654" xref: UniProtKB:P54132 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000004759 ! RecQ-like DNA helicase BLM relationship: has_gene_template HGNC:1058 ! BLM (human)