[Term] id: PR:000046510 name: serine/threonine-protein kinase B-raf, initiator methionine removed phosphorylated 6 (human) def: "A serine/threonine-protein kinase B-raf (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphoserine at positions 446 and 729 of the amino acid sequence represented by UniProtKB:P15056. UniProtKB:P15056, 2-766, Ser-446/Ser-729, MOD:00046." [PRO:DAN, Reactome:R-HSA-5672673] comment: Category=organism-modification. Note: A modified site indicated here (Ser-446) is referred to as Ser-445 in some manuscripts. [PRO:DAN, PMID:15710605] synonym: "hBRAF/InitMet-/Phos:6" EXACT PRO-short-label [PRO:DNx] synonym: "PRO_0000085665, Ser-446/Ser-729, MOD:00046" EXACT PRO-proteoform-ftid [PRO:DAN] synonym: "UniProtKB:P15056, 2-766, Ser-446/Ser-729, MOD:00046" EXACT PRO-proteoform-std [PRO:DAN] xref: Reactome:R-HSA-5672673 "PR:000046510 located_in GO:0005829" xref: Reactome:R-HSA-8933622 "PR:000046510 located_in GO:0005886" is_a: PR:P15056 ! serine/threonine-protein kinase B-raf (human) relationship: has_part MOD:00046 ! O-phospho-L-serine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens relationship: lacks_part PR:000021937 ! initiator methionine [Term] id: PR:000046507 name: serine/threonine-protein kinase B-raf, initiator methionine removed phosphorylated 3 (human) def: "A serine/threonine-protein kinase B-raf (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphoserine at position 339 of the amino acid sequence represented by UniProtKB:P15056. UniProtKB:P15056, 2-766, Ser-339, MOD:00046." [PRO:DNx, Reactome:R-HSA-1063700] comment: Category=organism-modification. synonym: "hBRAF/InitMet-/Phos:3" EXACT PRO-short-label [PRO:DNx] synonym: "PRO_0000085665, Ser-339, MOD:00046" EXACT PRO-proteoform-ftid [PRO:DNx] synonym: "UniProtKB:P15056, 2-766, Ser-339, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx] xref: Reactome:R-HSA-1063700 "PR:000046507 located_in GO:0005886" is_a: PR:P15056 ! serine/threonine-protein kinase B-raf (human) relationship: has_part MOD:00046 ! O-phospho-L-serine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens relationship: lacks_part PR:000021937 ! initiator methionine [Term] id: PR:000046506 name: serine/threonine-protein kinase B-raf, initiator methionine removed phosphorylated 2 (human) def: "A serine/threonine-protein kinase B-raf (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphoserine at positions 151, 446, 602, 729, and 750, and phosphothreonine at positions 401, 599 and 753 of the amino acid sequence represented by UniProtKB:P15056. UniProtKB:P15056, 2-766, Ser-151/Ser-446/Ser-602/Ser-729/Ser-750, MOD:00046|Thr-401/Thr-599/Thr-753, MOD:00047." [PRO:DAN, Reactome:R-HSA-5675199] comment: Category=organism-modification. Note: A modified site indicated here (Ser-446) is referred to as Ser-445 in some manuscripts. [PRO:DAN, PMID:15710605] synonym: "hBRAF/InitMet-/Phos:2" EXACT PRO-short-label [PRO:DNx] synonym: "PRO_0000085665, Ser-151/Ser-446/Ser-602/Ser-729/Ser-750, MOD:00046|Thr-401/Thr-599/Thr-753, MOD:00047" EXACT PRO-proteoform-ftid [PRO:DAN] synonym: "UniProtKB:P15056, 2-766, Ser-151/Ser-446/Ser-602/Ser-729/Ser-750, MOD:00046|Thr-401/Thr-599/Thr-753, MOD:00047" EXACT PRO-proteoform-std [PRO:DAN] xref: Reactome:R-HSA-5675199 "PR:000046506 located_in GO:0005886" is_a: PR:P15056 ! serine/threonine-protein kinase B-raf (human) relationship: has_part MOD:00046 ! O-phospho-L-serine relationship: has_part MOD:00047 ! O-phospho-L-threonine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens relationship: lacks_part PR:000021937 ! initiator methionine [Term] id: PR:000046505 name: serine/threonine-protein kinase B-raf, initiator methionine removed form (human) def: "A serine/threonine-protein kinase B-raf (human) that has had the initiator methionine removed. UniProtKB:P15056, 2-766." [PRO:DNx, Reactome:R-HSA-167224, Reactome:R-HSA-190063, Reactome:R-HSA-934547] comment: Category=organism-modification. synonym: "PRO_0000085665" EXACT PRO-proteoform-ftid [PRO:DNx] synonym: "hBRAF/InitMet-" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P15056, 2-766" EXACT PRO-proteoform-std [PRO:DNx] xref: Reactome:R-HSA-167224 "PR:000046505 located_in GO:0005829" xref: Reactome:R-HSA-190063 "PR:000046505 located_in GO:0005768" xref: Reactome:R-HSA-934547 "PR:000046505 located_in GO:0005886" intersection_of: lacks_part PR:000021937 ! initiator methionine intersection_of: PR:P15056 ! serine/threonine-protein kinase B-raf (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000046509 name: serine/threonine-protein kinase B-raf, initiator methionine removed phosphorylated 5 (human) def: "A serine/threonine-protein kinase B-raf (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphoserine at positions 446, 602 and 729, and phosphothreonine at position 599 of the amino acid sequence represented by UniProtKB:P15056. UniProtKB:P15056, 2-766, Ser-446/Ser-602/Ser-729, MOD:00046|Thr-599, MOD:00047." [PRO:DAN, Reactome:R-HSA-5672676, Reactome:R-HSA-5672679] comment: Category=organism-modification. Note: A modified site indicated here (Ser-446) is referred to as Ser-445 in some manuscripts. [PRO:DAN, PMID:15710605] synonym: "hBRAF/InitMet-/Phos:5" EXACT PRO-short-label [PRO:DNx] synonym: "PRO_0000085665, Ser-446/Ser-602/Ser-729, MOD:00046|Thr-599, MOD:00047" EXACT PRO-proteoform-ftid [PRO:DAN] synonym: "UniProtKB:P15056, 2-766, Ser-446/Ser-602/Ser-729, MOD:00046|Thr-599, MOD:00047" EXACT PRO-proteoform-std [PRO:DAN] xref: Reactome:R-HSA-5672676 "PR:000046509 located_in GO:0005829" xref: Reactome:R-HSA-5672679 "PR:000046509 located_in GO:0005886" is_a: PR:P15056 ! serine/threonine-protein kinase B-raf (human) relationship: has_part MOD:00046 ! O-phospho-L-serine relationship: has_part MOD:00047 ! O-phospho-L-threonine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens relationship: lacks_part PR:000021937 ! initiator methionine [Term] id: PR:000046508 name: serine/threonine-protein kinase B-raf, initiator methionine removed phosphorylated 4 (human) def: "A serine/threonine-protein kinase B-raf (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphoserine at positions 365, 446 and 729 of the amino acid sequence represented by UniProtKB:P15056. UniProtKB:P15056, 2-766, Ser-365/Ser-446/Ser-729, MOD:00046." [PRO:DAN, Reactome:R-HSA-5672667] comment: Category=organism-modification. Note: A modified site indicated here (Ser-446) is referred to as Ser-445 in some manuscripts. [PRO:DAN, PMID:15710605] synonym: "hBRAF/InitMet-/Phos:4" EXACT PRO-short-label [PRO:DNx] synonym: "PRO_0000085665, Ser-365/Ser-446/Ser-729, MOD:00046" EXACT PRO-proteoform-ftid [PRO:DAN] synonym: "UniProtKB:P15056, 2-766, Ser-365/Ser-446/Ser-729, MOD:00046" EXACT PRO-proteoform-std [PRO:DAN] xref: Reactome:R-HSA-5672667 "PR:000046508 located_in GO:0005829" is_a: PR:P15056 ! serine/threonine-protein kinase B-raf (human) relationship: has_part MOD:00046 ! O-phospho-L-serine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens relationship: lacks_part PR:000021937 ! initiator methionine [Term] id: PR:000045681 name: serine/threonine-protein kinase B-raf phosphorylated 1 (human) def: "A serine/threonine-protein kinase B-raf (human) that has been phosphorylated at Thr-753. UniProtKB:P15056, Thr-753, MOD:00047." [PMID:16508002, iPTMnet:P15056] comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:16508002). Status=unreviewed. synonym: "hBRAF/Phos:1" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P15056, Thr-753, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx] is_a: PR:P15056 ! serine/threonine-protein kinase B-raf (human) relationship: has_part MOD:00047 ! O-phospho-L-threonine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:P15056 name: serine/threonine-protein kinase B-raf (human) def: "A B-Raf proto-oncogene serine/threonine-protein kinase that is encoded in the genome of human." [PRO:DNx, UniProtKB:P15056] comment: Category=organism-gene. synonym: "BRAF" RELATED Gene-based [UniProtKB:P15056] synonym: "BRAF1" RELATED Gene-based [UniProtKB:P15056] synonym: "RAFB1" RELATED Gene-based [UniProtKB:P15056] synonym: "hBRAF" EXACT PRO-short-label [PRO:DNx] synonym: "p94 (human)" BROAD [UniProtKB:P15056] synonym: "proto-oncogene B-Raf (human)" EXACT [UniProtKB:P15056] synonym: "v-Raf murine sarcoma viral oncogene homolog B1 (human)" EXACT [UniProtKB:P15056] xref: DTO:03100047 xref: UniProtKB:P15056 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000004801 ! B-Raf proto-oncogene serine/threonine-protein kinase relationship: has_gene_template HGNC:1097 ! BRAF (human) [Term] id: PR:000004801 name: B-Raf proto-oncogene serine/threonine-protein kinase def: "A protein that is a translation product of the human BRAF gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "p94" BROAD [PRO:DNx] synonym: "BRAF" EXACT PRO-short-label [PRO:DNx] synonym: "B-raf" RELATED Gene-based [] synonym: "BRAF1" RELATED Gene-based [] synonym: "RAFB1" RELATED Gene-based [] synonym: "proto-oncogene B-Raf" EXACT [] synonym: "v-Raf murine sarcoma viral oncogene homolog B1" EXACT [] xref: IUPHARobj:1943 is_a: PR:000000001 ! protein