[Term]
id: PR:P51587
name: breast cancer type 2 susceptibility protein (human)
def: "A breast cancer type 2 susceptibility protein that is encoded in the genome of human." [PRO:DNx]
comment: Category=organism-gene.
synonym: "FACD" RELATED Gene-based [UniProtKB:P51587]
synonym: "BRCA2" RELATED Gene-based [UniProtKB:P51587]
synonym: "FANCD1" RELATED Gene-based [UniProtKB:P51587]
synonym: "hBRCA2" EXACT PRO-short-label [PRO:DNx]
synonym: "Fanconi anemia group D1 protein (human)" EXACT [UniProtKB:P51587]
xref: Reactome:R-HSA-50951 "PR:P51587 located_in GO:0005654"
xref: UniProtKB:P51587
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000004804 ! breast cancer type 2 susceptibility protein
relationship: has_gene_template HGNC:1101 ! BRCA2 (human)

[Term]
id: PR:000045544
name: breast cancer type 2 susceptibility protein phosphorylated 2 (human)
def: "A breast cancer type 2 susceptibility protein (human) that has been phosphorylated on a Thr residue within the CT domain. UniProtKB:P51587, Thr-3387, MOD:00047." [PMID:18317453, PMID:24627786, PRO:CNA, PRO:QW]
comment: Category=organism-modification. Kinase=("Chk1"; PR:O14757; Thr-3387). Kinase=("Chk2"; PR:O96017; Thr-3387). Evidence=(ECO:0000006, based on PMID:18317453). Note: Proteoform created based on papers selected via the eFIP text mining tool.
synonym: "hBRCA2/Phos:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P51587, Thr-3387, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-5685241 "PR:000045544 located_in GO:0005654"
is_a: PR:P51587 ! breast cancer type 2 susceptibility protein (human)
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000045545
name: breast cancer type 2 susceptibility protein unphosphorylated 2 (human)
def: "A breast cancer type 2 susceptibility protein (human) that lacks phosphorylation on a Thr residue within the CT domain. UniProtKB:P51587, Thr-3387, PR:000026291." [PMID:18317453, PRO:CNA, PRO:QW]
comment: Category=organism-modification.
synonym: "hBRCA2/UnPhos:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P51587, Thr-3387, PR:000026291" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:P51587 ! breast cancer type 2 susceptibility protein (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000035486
name: breast cancer type 2 susceptibility protein phosphorylated 1 (human)
def: "A breast cancer type 2 susceptibility protein phosphorylated 1 in human." [PMID:10749118, PRO:KER]
comment: Category=organism-modification. Kinase=("BUB1B"; PR:O60566).
synonym: "hBRCA2/Phos:1" EXACT PRO-short-label [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000035485 ! breast cancer type 2 susceptibility protein phosphorylated 1
relationship: has_part MOD:00696 ! phosphorylated residue

[Term]
id: PR:000045817
name: breast cancer type 2 susceptibility protein phosphorylated 3 (human)
def: "A breast cancer type 2 susceptibility protein (human) that has been phosphorylated at Ser-3291. UniProtKB:P51587, Ser-3291, MOD:00046." [PMID:15800615, iPTMnet:P51587]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:15800615). Status=unreviewed.
synonym: "hBRCA2/Phos:3" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P51587, Ser-3291, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:P51587 ! breast cancer type 2 susceptibility protein (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000004804
name: breast cancer type 2 susceptibility protein
def: "A BRCA protein that is a translation product of the human BRCA2 gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "FACD" RELATED Gene-based []
synonym: "BRCA2" EXACT PRO-short-label [PRO:DNx]
synonym: "FANCD1" RELATED Gene-based []
synonym: "Fanconi anemia group D1 protein" EXACT []
synonym: "Fanconi anemia group D1 protein homolog" EXACT []
is_a: PR:000050013 ! BRCA protein