[Term] id: PR:000035362 name: mitotic checkpoint serine/threonine-protein kinase BUB1 beta phosphorylated 1 (human) def: "A mitotic checkpoint serine/threonine-protein kinase BUB1 beta phosphorylated 1 in human. Example: UniProtKB:O60566-1, Thr-620, MOD:00047." [PMID:17785528, PRO:KER] comment: Category=organism-modification. Kinase=("CDK1"; PR:000003271). synonym: "hBUB1B/Phos:1" EXACT PRO-short-label [PRO:DNx] synonym: "hBUBR1 phosphorylated" RELATED [] synonym: "BUBR1 phosphorylated (human)" RELATED [] synonym: "UniProtKB:O60566-1, Thr-620, MOD:00047" NARROW PRO-proteoform-std [PRO:DNx] intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000035361 ! mitotic checkpoint serine/threonine-protein kinase BUB1 beta phosphorylated 1 relationship: has_part MOD:00047 ! O-phospho-L-threonine [Term] id: PR:000028798 name: mitotic checkpoint serine/threonine-protein kinase BUB1 beta isoform 1 acetylated 1 (human) def: "A mitotic checkpoint serine/threonine-protein kinase BUB1 beta isoform 1 acetylated 1 in human. Acetylation of this site inhibits ubiquitin mediated proteolysis and modulates timing for entry into anaphase. UniProtKB:O60566-1, Lys-250, MOD:00064." [PMID:19407811, PRO:PD] comment: Category=organism-modification. Acetylase=("KAT2B"; PR:000012332). synonym: "hBUB1B/iso:1/Ac:1" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:O60566-1, Lys-250, MOD:00064" EXACT PRO-proteoform-std [PRO:DNx] intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000028797 ! mitotic checkpoint serine/threonine-protein kinase BUB1 beta isoform 1 acetylated 1 relationship: has_part MOD:00064 ! N6-acetyl-L-lysine [Term] id: PR:000035432 name: mitotic checkpoint serine/threonine-protein kinase BUB1 beta phosphorylated 3 (human) def: "A mitotic checkpoint serine/threonine-protein kinase BUB1 beta phosphorylated 3 in human. This phosphorylated form is observed in prometaphase and in conditions of spindle depolymerization (nocodazole). Example: UniProtKB:O60566-1, Thr-608, MOD:00047." [PMID:10593653, PMID:10749118, PMID:22801780, PRO:KER] comment: Category=organism-modification. One of the articles cited mentions BUB1B (PR:O60566) as the kinase when bound to CENPE (PR:Q02224). synonym: "hBUB1B/Phos:3" EXACT PRO-short-label [PRO:DNx] synonym: "hBUBR1 phosphorylated" RELATED [] synonym: "BUBR1 phosphorylated (human)" RELATED [] synonym: "UniProtKB:O60566-1, Thr-608, MOD:00047" NARROW PRO-proteoform-std [PRO:DNx] intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000035431 ! mitotic checkpoint serine/threonine-protein kinase BUB1 beta phosphorylated 3 relationship: has_part MOD:00047 ! O-phospho-L-threonine [Term] id: PR:000035435 name: mitotic checkpoint serine/threonine-protein kinase BUB1 beta phosphorylated 4 (human) def: "A mitotic checkpoint serine/threonine-protein kinase BUB1 beta phosphorylated 4 in human. This phosphorylated form is observed in prophase, prometaphase, metaphase, anaphase, spindle depolymerization (nocodazole). This form is not observed when there is a lack of kinetochore tension (taxol). Ser-435, Ser-574 and Ser-720 could also be phosphorylated. Example: UniProtKB:O60566-1, Ser-543/Ser-670/Ser-1043, MOD:00046." [PMID:19015317, PMID:20016069, PRO:KER] comment: Category=organism-modification. Kinase=("CDK1"; PR:000003271). synonym: "hBUB1B/Phos:4" EXACT PRO-short-label [PRO:DNx] synonym: "hBUBR1 phosphorylated" RELATED [] synonym: "BUBR1 phosphorylated (human)" RELATED [] synonym: "UniProtKB:O60566-1, Ser-543/Ser-670/Ser-1043, MOD:00046" NARROW PRO-proteoform-std [PRO:DNx] intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000035434 ! mitotic checkpoint serine/threonine-protein kinase BUB1 beta phosphorylated 4 relationship: has_part MOD:00046 ! O-phospho-L-serine [Term] id: PR:000035373 name: mitotic checkpoint serine/threonine-protein kinase BUB1 beta unphosphorylated form (human) def: "A mitotic checkpoint serine/threonine-protein kinase BUB1 beta unphosphorylated form in human." [PRO:CNA] comment: Category=organism-modification. synonym: "hBUB1B/PhosRes-" EXACT PRO-short-label [PRO:DNx] intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000035372 ! mitotic checkpoint serine/threonine-protein kinase BUB1 beta unphosphorylated form [Term] id: PR:000004855 name: mitotic checkpoint serine/threonine-protein kinase BUB1 beta def: "A BUB1/BUB1B protein that is a translation product of the human BUB1B gene or a 1:1 ortholog thereof." [PMID:22698286, PRO:CNA] comment: Category=gene. synonym: "SSK1" RELATED Gene-based [] synonym: "BUB1B" EXACT PRO-short-label [PRO:DNx] synonym: "BUBR1" RELATED Gene-based [] synonym: "BubR1" EXACT [] synonym: "MAD3L" RELATED Gene-based [] synonym: "protein SSK1" EXACT [] synonym: "mitotic checkpoint kinase MAD3L" EXACT [] synonym: "MAD3/BUB1-related protein kinase" EXACT [] xref: IUPHARobj:1950 is_a: PR:000035665 ! BUB1/BUB1B protein [Term] id: PR:O60566 name: mitotic checkpoint serine/threonine-protein kinase BUB1 beta (human) def: "A mitotic checkpoint serine/threonine-protein kinase BUB1 beta that is encoded in the genome of human." [PRO:DNx, UniProtKB:O60566] comment: Category=organism-gene. synonym: "SSK1" RELATED Gene-based [UniProtKB:O60566] synonym: "BUB1B" RELATED Gene-based [UniProtKB:O60566] synonym: "BUBR1" RELATED Gene-based [UniProtKB:O60566] synonym: "MAD3L" RELATED Gene-based [UniProtKB:O60566] synonym: "hBUB1B" EXACT PRO-short-label [PRO:DNx] synonym: "hBUBR1" EXACT [UniProtKB:O60566] synonym: "protein SSK1 (human)" EXACT [UniProtKB:O60566] synonym: "mitotic checkpoint kinase MAD3L (human)" EXACT [UniProtKB:O60566] synonym: "MAD3/BUB1-related protein kinase (human)" EXACT [UniProtKB:O60566] xref: Reactome:R-HSA-141436 "PR:O60566 located_in GO:0005829" xref: DTO:03100051 xref: UniProtKB:O60566 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000004855 ! mitotic checkpoint serine/threonine-protein kinase BUB1 beta relationship: has_gene_template HGNC:1149 ! BUB1B (human) [Term] id: PR:O60566-2 name: mitotic checkpoint serine/threonine-protein kinase BUB1 beta isoform h2 (human) def: "A mitotic checkpoint serine/threonine-protein kinase BUB1 beta (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O60566-2." [PRO:DNx, UniProtKB:O60566] comment: Category=organism-sequence. synonym: "hBUB1B/iso:h2" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:O60566-2 is_a: PR:O60566 ! mitotic checkpoint serine/threonine-protein kinase BUB1 beta (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:O60566-3 name: mitotic checkpoint serine/threonine-protein kinase BUB1 beta isoform h3 (human) def: "A mitotic checkpoint serine/threonine-protein kinase BUB1 beta (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O60566-3." [PRO:DNx, UniProtKB:O60566] comment: Category=organism-sequence. synonym: "hBUB1B/iso:h3" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:O60566-3 is_a: PR:O60566 ! mitotic checkpoint serine/threonine-protein kinase BUB1 beta (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000035428 name: mitotic checkpoint serine/threonine-protein kinase BUB1 beta phosphorylated 2 (human) def: "A mitotic checkpoint serine/threonine-protein kinase BUB1 beta CDK1- and PLK1-phosphorylated form in human that has had Thr-620 phosphorylated by CDK1, and Ser-676 and/or Thr-680 phosphorylated by PLK1. Additionally, Thr-792 and/or Thr-1008 may be phosphorylated based on in vitro experiments. This phosphorylated form is observed during pro metaphase, spindle depolymerization (nocodazole), and lack of kinetochore tension (taxol). Example: UniProtKB:O60566, Thr-620, MOD:00047|(Ser-676, MOD:00046 and/or Thr-680, MOD:00047)|(Thr-792, MOD:00047 and/or Thr-1008, MOD:00047)." [PMID:10593653, PMID:11030144, PMID:11792804, PMID:17276342, PMID:17376779, PMID:17785528, PMID:18440313, PMID:23079597, PRO:KER] comment: Category=organism-modification. Kinase=("CDK1"; PR:000003271). Kinase=("PLK1"; PR:P53350). synonym: "hBUB1B/Phos:2" EXACT PRO-short-label [PRO:DNx] synonym: "hBUBR1 phosphorylated" RELATED [] synonym: "BUBR1 phosphorylated (human)" RELATED [] synonym: "UniProtKB:O60566, Thr-620, MOD:00047|(Ser-676, MOD:00046 and/or Thr-680, MOD:00047)|(Thr-792, MOD:00047 and/or Thr-1008, MOD:00047)" NARROW PRO-proteoform-std [PRO:DNx] is_a: PR:000035427 ! mitotic checkpoint serine/threonine-protein kinase BUB1 beta CDK1- and PLK1-phosphorylated form relationship: has_part MOD:00046 ! O-phospho-L-serine relationship: has_part MOD:00047 ! O-phospho-L-threonine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:O60566-1 name: mitotic checkpoint serine/threonine-protein kinase BUB1 beta isoform 1 (human) def: "A mitotic checkpoint serine/threonine-protein kinase BUB1 beta isoform 1 that is encoded in the genome of human." [PRO:PD] comment: Category=organism-sequence. synonym: "hBUB1B/iso:1" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:O60566-1 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000028795 ! mitotic checkpoint serine/threonine-protein kinase BUB1 beta isoform 1