[Term]
id: PR:O14757
name: serine/threonine-protein kinase Chk1 (human)
def: "A serine/threonine-protein kinase Chk1 that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-gene.
synonym: "CHK1" RELATED Gene-based [UniProtKB:O14757]
synonym: "CHEK1" RELATED Gene-based [UniProtKB:O14757]
synonym: "hCHEK1" EXACT PRO-short-label [PRO:DNx]
synonym: "checkpoint kinase-1 (human)" EXACT [UniProtKB:O14757]
synonym: "CHK1 checkpoint homolog (human)" EXACT [UniProtKB:O14757]
synonym: "cell cycle checkpoint kinase (human)" EXACT [UniProtKB:O14757]
xref: Reactome:R-HSA-113826 "PR:O14757 located_in GO:0005654"
xref: Reactome:R-HSA-205285 "PR:O14757 located_in GO:0005829"
xref: DTO:03100082
xref: UniProtKB:O14757
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000005417 ! serine/threonine-protein kinase Chk1
relationship: has_gene_template HGNC:1925 ! CHEK1 (human)

[Term]
id: PR:000045568
name: serine/threonine-protein kinase Chk1 phosphorylated 1 (human)
def: "A serine/threonine-protein kinase Chk1 (human) that has been phosphorylated on the residue at the position equivalent to Ser-345 of the amino acid sequence represented by UniProtKB:O14757-1. Example: UniProtKB:O14757-1, Ser-345, MOD:00046." [PMID:10859164, PMID:14681223, PMID:15533933, iPTMnet:O14757]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:10859164, PMID:14681223, PMID:15533933). Status=unreviewed.
synonym: "hCHEK1/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:O14757-1, Ser-345, MOD:00046" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:O14757 ! serine/threonine-protein kinase Chk1 (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000046701
name: serine/threonine-protein kinase Chk1 phosphorylated 2 (human)
def: "A serine/threonine-protein kinase Chk1 (human) that has been post-translationally modified to include phosphoserine at positions 317 and 345 of the amino acid sequence represented by UniProtKB:O14757. UniProtKB:O14757, Ser-317/Ser-345, MOD:00046." [PRO:DNx, Reactome:R-HSA-113838]
comment: Category=organism-modification.
synonym: "hCHEK1/Phos:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:O14757, Ser-317/Ser-345, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-113838 "PR:000046701 located_in GO:0005654"
is_a: PR:O14757 ! serine/threonine-protein kinase Chk1 (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:O14757-3
name: serine/threonine-protein kinase Chk1 isoform h3 (human)
def: "A serine/threonine-protein kinase Chk1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O14757-3." [PRO:DNx, UniProtKB:O14757]
comment: Category=organism-sequence.
synonym: "hCHEK1/iso:h3" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:O14757-3
is_a: PR:O14757 ! serine/threonine-protein kinase Chk1 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:O14757-2
name: serine/threonine-protein kinase Chk1 isoform 2 (human)
def: "A serine/threonine-protein kinase Chk1 isoform 2 that is encoded in the genome of human." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "hCHEK1/iso:2" EXACT PRO-short-label [PRO:DNx]
synonym: "serine/threonine-protein kinase Chk1 isoform Chk1-S (human)" EXACT [UniProtKB:O14757]
synonym: "serine/threonine-protein kinase Chk1 isoform Chk1-short (human)" EXACT [UniProtKB:O14757]
xref: UniProtKB:O14757-2
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000037998 ! serine/threonine-protein kinase Chk1 isoform 2

[Term]
id: PR:O14757-1
name: serine/threonine-protein kinase Chk1 isoform 1 (human)
def: "A serine/threonine-protein kinase Chk1 isoform 1 that is encoded in the genome of human." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "hCHEK1/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:O14757-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000037997 ! serine/threonine-protein kinase Chk1 isoform 1

[Term]
id: PR:000005417
name: serine/threonine-protein kinase Chk1
def: "A protein that is a translation product of the human CHEK1 gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "CHK1" RELATED Gene-based []
synonym: "CHEK1" EXACT PRO-short-label [PRO:DNx]
synonym: "checkpoint kinase 1" EXACT []
synonym: "checkpoint kinase-1" EXACT []
synonym: "CHK1 checkpoint homolog" EXACT []
xref: IUPHARobj:1987
is_a: PR:000000001 ! protein